ZEB1

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ZEB1
Protein ZEB1 PDB 2e19.png
Available structures
PDB Ortholog search: PDBe RCSB
Identifiers
Aliases ZEB1, zinc finger E-box binding homeobox 1, AREB6, BZP, DELTAEF1, FECD6, NIL2A, PPCD3, TCF8, ZFHEP, ZFHX1A
External IDs MGI: 1344313 HomoloGene: 31779 GeneCards: 6935
RNA expression pattern
PBB GE ZEB1 210875 s at tn.png

PBB GE ZEB1 212758 s at tn.png

PBB GE ZEB1 212764 at tn.png
More reference expression data
Orthologs
Species Human Mouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_011546

RefSeq (protein)

NP_035676.1

Location (UCSC) Chr 10: 31.32 – 31.53 Mb Chr 18: 5.59 – 5.78 Mb
PubMed search [1] [2]
Wikidata
View/Edit Human View/Edit Mouse

Zinc finger E-box-binding homeobox 1 is a protein that in humans is encoded by the ZEB1 gene.[3][4][5]

ZEB1 (previously known as TCF8) encodes a zinc finger and homeodomain transcription factor that represses T-lymphocyte-specific IL2 gene expression by binding to a negative regulatory domain 100 nucleotides 5-prime of the IL2 transcription start site.[5][6] ZEB1 and its mammalian paralog ZEB2 belongs to the Zeb family within the ZF (zinc finger) class of homeodomain transcription factors. ZEB1 protein has 7 zinc fingers and 1 homeodomain.[7] The structure of the homeodomain shown on the right.

Clinical significance[edit]

Mutations of the gene are linked to posterior polymorphous corneal dystrophy 3. A recent study suggested its contributing role in lung cancer invasiveness and metastasis development.[8]

References[edit]

  1. ^ "Human PubMed Reference:". 
  2. ^ "Mouse PubMed Reference:". 
  3. ^ Williams TM, Montoya G, Wu Y, Eddy RL, Byers MG, Shows TB (Dec 1992). "The TCF8 gene encoding a zinc finger protein (Nil-2-a) resides on human chromosome 10p11.2". Genomics. 14 (1): 194–6. doi:10.1016/S0888-7543(05)80307-6. PMID 1427828. 
  4. ^ Williams TM, Moolten D, Burlein J, Romano J, Bhaerman R, Godillot A, Mellon M, Rauscher FJ, Kant JA (Feb 1992). "Identification of a zinc finger protein that inhibits IL-2 gene expression". Science. 254 (5039): 1791–4. doi:10.1126/science.1840704. PMID 1840704. 
  5. ^ a b "Entrez Gene: ZEB1 zinc finger E-box binding homeobox 1". 
  6. ^ Williams TM, Moolten D, Burlein J, Romano J, Bhaerman R, Godillot A, Mellon M, Rauscher FJ, Kant JA (December 1991). "Identification of a zinc finger protein that inhibits IL-2 gene expression". Science. 254 (5039): 1791–4. doi:10.1126/science.1840704. PMID 1840704. 
  7. ^ Bürglin TR, Affolter M (2015). "Homeodomain proteins: an update". Chromosoma. x (x): x. doi:10.1007/s00412-015-0543-8. PMID 26464018. 
  8. ^ Liu W, Huang YJ, Liu C, Yang YY, Liu H, Cui JG, Cheng Y, Gao F, Cai JM, Li BL (2014). "Inhibition of TBK1 attenuates radiation-induced epithelial-mesenchymal transition of A549 human lung cancer cells via activation of GSK-3β and repression of ZEB1". Lab. Invest. 94 (4): 362–70. doi:10.1038/labinvest.2013.153. PMID 24468793. 

Further reading[edit]

External links[edit]