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Zinc finger E-box binding homeobox 2
Protein ZEB2 PDB 2da7.png
PDB rendering based on 2da7.
Available structures
PDB Ortholog search: PDBe, RCSB
Symbols ZEB2 ; HSPC082; SIP-1; SIP1; SMADIP1; ZFHX1B
External IDs OMIM605802 MGI1344407 HomoloGene8868 GeneCards: ZEB2 Gene
RNA expression pattern
PBB GE ZEB2 203603 s at tn.png
More reference expression data
Species Human Mouse
Entrez 9839 24136
Ensembl ENSG00000169554 ENSMUSG00000026872
UniProt O60315 Q9R0G7
RefSeq (mRNA) NM_001171653 NM_001289521
RefSeq (protein) NP_001165124 NP_001276450
Location (UCSC) Chr 2:
144.38 – 144.52 Mb
Chr 2:
44.98 – 45.12 Mb
PubMed search [1] [2]

Zinc finger E-box-binding homeobox 2 is a protein that in humans is encoded by the ZEB2 gene.[1]


The SMADIP1 gene (also known as SIP1) is a member of the delta-EF1 (TCF8)/Zfh1 family of 2-handed zinc finger/homeodomain proteins. SMADIP1 interacts with receptor-mediated, activated full-length SMADs.[1]

Clinical significance[edit]

Mutations in the ZEB2 gene are associated with the Mowat-Wilson syndrome.


External links[edit]

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