ZFP36

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ZFP36
Protein ZFP36 PDB 1m9o.png
Available structures
PDB Ortholog search: PDBe RCSB
Identifiers
Aliases ZFP36, G0S24, GOS24, NUP475, RNF162A, TIS11, TTP, zfp-36, ZFP36 ring finger protein
External IDs MGI: 99180 HomoloGene: 2558 GeneCards: ZFP36
RNA expression pattern
PBB GE ZFP36 201531 at fs.png
More reference expression data
Orthologs
Species Human Mouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_003407

NM_011756

RefSeq (protein)

NP_003398

NP_035886.1
NP_035886

Location (UCSC) Chr 19: 39.41 – 39.41 Mb Chr 7: 28.38 – 28.38 Mb
PubMed search [1] [2]
Wikidata
View/Edit Human View/Edit Mouse

Tristetraprolin (TTP), also known as zinc finger protein 36 homolog (ZFP36), is a protein that in humans, mice and rats is encoded by the ZFP36 gene.[3][4] It is a member of the TIS11 (TPA-induced sequence) family, along with butyrate response factors 1 and 2.[5]

TTP binds to AU-rich elements (AREs) in the 3'-untranslated regions (UTRs) of the mRNAs of some cytokines and promotes their degradation. For example, TTP is a component of a negative feedback loop that interferes with TNF-alpha production by destabilizing its mRNA.[6] Mice deficient in TTP develop a complex syndrome of inflammatory diseases.[6]

Interactions[edit]

ZFP36 has been shown to interact with 14-3-3 protein family members, such as YWHAH,[7] and with NUP214, a member of the nuclear pore complex.[8]

Regulation[edit]

Post-transcriptionally, TTP is regulated in several ways.[5] The subcellular localization of TTP is influenced by interactions with protein partners such as the 14-3-3 family of proteins. These interactions and, possibly, interactions with target mRNAs are affected by the phosphorylation state of TTP, as the protein can be posttranslationally modified by a large number of protein kinases.[5] There is some evidence that the TTP transcript may also be targeted by microRNAs, such as miR-29a.[5]

References[edit]

  1. ^ "Human PubMed Reference:". 
  2. ^ "Mouse PubMed Reference:". 
  3. ^ DuBois RN, McLane MW, Ryder K, Lau LF, Nathans D (Dec 1990). "A growth factor-inducible nuclear protein with a novel cysteine/histidine repetitive sequence". J Biol Chem. 265 (31): 19185–91. PMID 1699942. 
  4. ^ "Entrez Gene: ZFP36 zinc finger protein 36, C3H type, homolog (mouse)". 
  5. ^ a b c d Sanduja S, Blanco FF, Dixon DA (2011). "The roles of TTP and BRF proteins in regulated mRNA decay". Wiley Interdiscip Rev RNA. 2 (1): 42–57. doi:10.1002/wrna.28. PMC 3030256Freely accessible. PMID 21278925. 
  6. ^ a b Carballo E, Lai WS, Blackshear PJ (August 1998). "Feedback inhibition of macrophage tumor necrosis factor-alpha production by tristetraprolin". Science. 281 (5379): 1001–5. doi:10.1126/science.281.5379.1001. PMID 9703499. 
  7. ^ Johnson BA, Stehn JR, Yaffe MB, Blackwell TK (May 2002). "Cytoplasmic localization of tristetraprolin involves 14-3-3-dependent and -independent mechanisms". J. Biol. Chem. 277 (20): 18029–36. doi:10.1074/jbc.M110465200. PMID 11886850. 
  8. ^ Carman JA, Nadler SG (March 2004). "Direct association of tristetraprolin with the nucleoporin CAN/Nup214". Biochem. Biophys. Res. Commun. 315 (2): 445–9. doi:10.1016/j.bbrc.2004.01.080. PMID 14766228. 

Further reading[edit]