ZFP36L1

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ZFP36L1
Protein ZFP36L1 PDB 1rgo.png
Available structures
PDB Ortholog search: PDBe RCSB
Identifiers
Aliases ZFP36L1, BRF1, Berg36, ERF-1, ERF1, RNF162B, TIS11B, cMG1, ZFP36 ring finger protein-like 1
External IDs MGI: 107946 HomoloGene: 31276 GeneCards: ZFP36L1
Genetically Related Diseases
multiple sclerosis[1]
RNA expression pattern
PBB GE ZFP36L1 211962 s at fs.png

PBB GE ZFP36L1 213277 at fs.png
More reference expression data
Orthologs
Species Human Mouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_004926
NM_001244698
NM_001244701

NM_007564

RefSeq (protein)

NP_001231627
NP_001231630
NP_004917

NP_031590.1
NP_031590

Location (UCSC) Chr 14: 68.79 – 68.8 Mb Chr 12: 80.11 – 80.11 Mb
PubMed search [2] [3]
Wikidata
View/Edit Human View/Edit Mouse

Butyrate response factor 1 is a protein that in humans is encoded by the ZFP36L1 gene.[4][5]

Function[edit]

This gene is a member of the TIS11 family of early response genes. Family members are induced by various agonists such as the phorbol ester TPA and the polypeptide mitogen EGF. The gene is well conserved across species and has a promoter that contains motifs seen in other early-response genes. The encoded protein contains a distinguishing putative zinc finger domain with a repeating cys-his motif. This RNA binding protein most likely functions in regulating the response to growth factors.[5]

Interactions[edit]

ZFP36L1 has been shown to interact with MAPK14.[6]

References[edit]

  1. ^ "Diseases that are genetically associated with ZFP36L1 view/edit references on wikidata". 
  2. ^ "Human PubMed Reference:". 
  3. ^ "Mouse PubMed Reference:". 
  4. ^ Bustin SA, Nie XF, Barnard RC, Kumar V, Pascall JC, Brown KD, Leigh IM, Williams NS, McKay IA (Aug 1994). "Cloning and characterization of ERF-1, a human member of the Tis11 family of early-response genes". DNA Cell Biol. 13 (5): 449–59. doi:10.1089/dna.1994.13.449. PMID 8024689. 
  5. ^ a b "Entrez Gene: ZFP36L1 zinc finger protein 36, C3H type-like 1". 
  6. ^ Rual JF, Venkatesan K, Hao T, Hirozane-Kishikawa T, Dricot A, Li N, Berriz GF, Gibbons FD, Dreze M, Ayivi-Guedehoussou N, Klitgord N, Simon C, Boxem M, Milstein S, Rosenberg J, Goldberg DS, Zhang LV, Wong SL, Franklin G, Li S, Albala JS, Lim J, Fraughton C, Llamosas E, Cevik S, Bex C, Lamesch P, Sikorski RS, Vandenhaute J, Zoghbi HY, Smolyar A, Bosak S, Sequerra R, Doucette-Stamm L, Cusick ME, Hill DE, Roth FP, Vidal M (October 2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature. 437 (7062): 1173–8. doi:10.1038/nature04209. PMID 16189514. 

Further reading[edit]