ZFP57

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ZFP57
Identifiers
Aliases ZFP57, C6orf40, TNDM1, ZNF698, bA145L22, bA145L22.2, ZFP57 zinc finger protein
External IDs MGI: 99204 HomoloGene: 7603 GeneCards: ZFP57
Orthologs
Species Human Mouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_001109809

NM_001013745
NM_001168501
NM_001168502
NM_009559

RefSeq (protein)

NP_001103279
NP_001103279.2

Location (UCSC) Chr 6: 29.67 – 29.68 Mb Chr 17: 37 – 37.01 Mb
PubMed search [1] [2]
Wikidata
View/Edit Human View/Edit Mouse

Zinc finger protein 57 homolog (ZFP57), also known as zinc finger protein 698 (ZNF698), is a protein that in humans is encoded by the ZFP57 gene.[3]

Function[edit]

The protein encoded by this gene is a zinc finger protein containing a KRAB domain. Studies in mouse suggest that this protein may function as a transcriptional repressor.[3]

Clinical significance[edit]

Mutations in the ZFP57 gene may be associated with transient neonatal diabetes mellitus.[4]

References[edit]

  1. ^ "Human PubMed Reference:". 
  2. ^ "Mouse PubMed Reference:". 
  3. ^ a b "Entrez Gene: zinc finger protein 57 homolog (mouse)". 
  4. ^ Mackay DJ, Callaway JL, Marks SM, et al. (August 2008). "Hypomethylation of multiple imprinted loci in individuals with transient neonatal diabetes is associated with mutations in ZFP57". Nat. Genet. 40 (8): 949–51. doi:10.1038/ng.187. PMID 18622393. 

Further reading[edit]

This article incorporates text from the United States National Library of Medicine, which is in the public domain.