ZHX1

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ZHX1
Protein ZHX1 PDB 2ecb.png
Available structures
PDB Ortholog search: PDBe RCSB
Identifiers
Aliases ZHX1, zinc fingers and homeoboxes 1
External IDs MGI: 109271 HomoloGene: 5225 GeneCards: ZHX1
RNA expression pattern
PBB GE ZHX1 gnf1h00108 at fs.png
More reference expression data
Orthologs
Species Human Mouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_001017926
NM_007222

NM_001042438
NM_009572

RefSeq (protein)

NP_001017926
NP_009153

NP_001035903.1
NP_033598.2
NP_001035903
NP_033598

Location (UCSC) Chr 8: 123.25 – 123.28 Mb Chr 15: 58.05 – 58.08 Mb
PubMed search [1] [2]
Wikidata
View/Edit Human View/Edit Mouse

Zinc fingers and homeoboxes protein 1 is a protein that in humans is encoded by the ZHX1 gene.[3][4]

The members of the zinc fingers and homeoboxes gene family are nuclear homodimeric transcriptional repressors that interact with the A subunit of nuclear factor-Y (NF-YA) and contain two C2H2-type zinc fingers and five homeobox DNA-binding domains. This gene encodes member 1 of this gene family. In addition to forming homodimers, this protein heterodimerizes with members 2 and 3 of the zinc fingers and homeoboxes family. Alternative splicing results in multiple transcript variants encoding the same protein.[4]

Interactions[edit]

ZHX1 has been shown to interact with NFYA.[3][5]

References[edit]

  1. ^ "Human PubMed Reference:". 
  2. ^ "Mouse PubMed Reference:". 
  3. ^ a b Yamada K, Printz RL, Osawa H, Granner DK (Sep 1999). "Human ZHX1: cloning, chromosomal location, and interaction with transcription factor NF-Y". Biochem Biophys Res Commun. 261 (3): 614–21. doi:10.1006/bbrc.1999.1087. PMID 10441475. 
  4. ^ a b "Entrez Gene: ZHX1 zinc fingers and homeoboxes 1". 
  5. ^ Yamada, K; Osawa H; Granner D K (Oct 1999). "Identification of proteins that interact with NF-YA". FEBS Lett. NETHERLANDS. 460 (1): 41–5. doi:10.1016/S0014-5793(99)01311-3. ISSN 0014-5793. PMID 10571058. 

Further reading[edit]