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Clinical data
Other namesBAY 86-5310; SH-T04211C
Routes of
By mouth[1]
Drug classEstrogen; Selective ERβ agonist
CAS Number

ZK-283197 (also known as BAY 86-5310 or SH-T04211C) is a selective and orally active ERβ agonist which was under development by Bayer Healthcare AG for the treatment of vasomotor symptoms.[1][2] It reached phase II clinical trials prior to the discontinuation of its development.[1] Its development was terminated in 2014.[1]


  1. ^ a b c d "ZK 283197 - AdisInsight". adisinsight.springer.com.
  2. ^ US 14/332,204, Pietras, R. J., & Jung, M. E., "Methods of using estrogen receptor-beta ligands as radiation mitigators"