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AliasesZNF10, KOX1, zinc finger protein 10
External IDsHomoloGene: 130674 GeneCards: ZNF10
Gene location (Human)
Chromosome 12 (human)
Chr.Chromosome 12 (human)[1]
Chromosome 12 (human)
Genomic location for ZNF10
Genomic location for ZNF10
Band12q24.33Start133,130,575 bp[1]
End133,159,465 bp[1]
RNA expression pattern
PBB GE ZNF10 216350 s at fs.png
More reference expression data
RefSeq (mRNA)



RefSeq (protein)



Location (UCSC)Chr 12: 133.13 – 133.16 Mbn/a
PubMed search[2]n/a
View/Edit Human

Zinc finger protein 10 is a protein that in humans is encoded by the ZNF10 gene.[3][4][5]


The protein encoded by this gene contains a C2H2 zinc finger, and has been shown to function as a transcriptional repressor. The Kruppel-associated box (KRAB) domain of this protein is found to be responsible for its transcriptional repression activity. RING finger containing protein TIF1 was reported to interact with the KRAB domain, and may serve as a mediator for the repression activity of this protein.[5]


ZNF10 has been shown to interact with TRIM28.[6][7]


  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000256223 - Ensembl, May 2017
  2. ^ "Human PubMed Reference:".
  3. ^ Abrink M, Aveskogh M, Hellman L (Feb 1995). "Isolation of cDNA clones for 42 different Krüppel-related zinc finger proteins expressed in the human monoblast cell line U-937". DNA and Cell Biology. 14 (2): 125–36. doi:10.1089/dna.1995.14.125. PMID 7865130.
  4. ^ Rousseau-Merck MF, Hillion J, Jonveaux P, Couillin P, Seité P, Thiesen HJ, Berger R (Dec 1993). "Chromosomal localization of 9 KOX zinc finger genes: physical linkages suggest clustering of KOX genes on chromosomes 12, 16, and 19". Human Genetics. 92 (6): 583–7. doi:10.1007/BF00420943. PMID 8262519.
  5. ^ a b "Entrez Gene: ZNF10 zinc finger protein 10".
  6. ^ Moosmann P, Georgiev O, Le Douarin B, Bourquin JP, Schaffner W (Dec 1996). "Transcriptional repression by RING finger protein TIF1 beta that interacts with the KRAB repressor domain of KOX1". Nucleic Acids Research. 24 (24): 4859–67. doi:10.1093/nar/24.24.4859. PMC 146346. PMID 9016654.
  7. ^ Peng H, Begg GE, Harper SL, Friedman JR, Speicher DW, Rauscher FJ (Jun 2000). "Biochemical analysis of the Kruppel-associated box (KRAB) transcriptional repression domain". The Journal of Biological Chemistry. 275 (24): 18000–10. doi:10.1074/jbc.M001499200. PMID 10748030.

Further reading[edit]

External links[edit]

This article incorporates text from the United States National Library of Medicine, which is in the public domain.