The protein encoded by this gene contains a C2H2 zinc finger, and has been shown to function as a transcriptional repressor. The Kruppel-associated box (KRAB) domain of this protein is found to be responsible for its transcriptional repression activity. RING finger containing protein TIF1 was reported to interact with the KRAB domain, and may serve as a mediator for the repression activity of this protein.
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^Rousseau-Merck MF, Hillion J, Jonveaux P, Couillin P, Seité P, Thiesen HJ, Berger R (Dec 1993). "Chromosomal localization of 9 KOX zinc finger genes: physical linkages suggest clustering of KOX genes on chromosomes 12, 16, and 19". Human Genetics. 92 (6): 583–7. doi:10.1007/BF00420943. PMID8262519.
Moosmann P, Georgiev O, Thiesen HJ, Hagmann M, Schaffner W (Jul 1997). "Silencing of RNA polymerases II and III-dependent transcription by the KRAB protein domain of KOX1, a Krüppel-type zinc finger factor". Biological Chemistry. 378 (7): 669–77. doi:10.1515/bchm.1997.378.7.669. PMID9278146.
Peng H, Begg GE, Harper SL, Friedman JR, Speicher DW, Rauscher FJ (Jun 2000). "Biochemical analysis of the Kruppel-associated box (KRAB) transcriptional repression domain". The Journal of Biological Chemistry. 275 (24): 18000–10. doi:10.1074/jbc.M001499200. PMID10748030.
Lorenz P, Koczan D, Thiesen HJ (Apr 2001). "Transcriptional repression mediated by the KRAB domain of the human C2H2 zinc finger protein Kox1/ZNF10 does not require histone deacetylation". Biological Chemistry. 382 (4): 637–44. doi:10.1515/BC.2001.075. PMID11405226.