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Zinc finger protein 217
Available structures
PDB Ortholog search: PDBe, RCSB
Symbols ZNF217 ; ZABC1
External IDs OMIM602967 MGI2685408 HomoloGene4757 GeneCards: ZNF217 Gene
RNA expression pattern
PBB GE ZNF217 203739 at tn.png
More reference expression data
Species Human Mouse
Entrez 7764 228913
Ensembl ENSG00000171940 ENSMUSG00000052056
UniProt O75362 Q3U0X6
RefSeq (mRNA) NM_006526 NM_001033299
RefSeq (protein) NP_006517 NP_001028471
Location (UCSC) Chr 20:
52.18 – 52.23 Mb
Chr 2:
170.11 – 170.15 Mb
PubMed search [1] [2]

Zinc finger protein 217, also known as ZNF217, is a protein which in humans is encoded by the ZNF217 gene.[1][2]


ZNF217 can attenuate apoptotic signals resulting from telomere dysfunction and may promote neoplastic transformation and later stages of malignancy.[3] Znf217 was shown to be a prognostic biomarker and therapeutic target during breast cancer progression.[4]

See also[edit]


  1. ^ Collins C, Rommens JM, Kowbel D, Godfrey T, Tanner M, Hwang SI et al. (Jul 1998). "Positional cloning of ZNF217 and NABC1: genes amplified at 20q13.2 and overexpressed in breast carcinoma". Proceedings of the National Academy of Sciences of the United States of America 95 (15): 8703–8. doi:10.1073/pnas.95.15.8703. PMC 21140. PMID 9671742. 
  2. ^ "Entrez Gene: ZNF217 zinc finger protein 217". 
  3. ^ Huang G, Krig S, Kowbel D, Xu H, Hyun B, Volik S et al. (Nov 2005). "ZNF217 suppresses cell death associated with chemotherapy and telomere dysfunction". Human Molecular Genetics 14 (21): 3219–25. doi:10.1093/hmg/ddi352. PMID 16203743. 
  4. ^ Littlepage LE, Adler AS, Kouros-Mehr H, Huang G, Chou J, Krig SR et al. (Jul 2012). "The transcription factor ZNF217 is a prognostic biomarker and therapeutic target during breast cancer progression". Cancer Discovery 2 (7): 638–51. doi:10.1158/2159-8290.CD-12-0093. PMC 3546490. PMID 22728437. 

Further reading[edit]

External links[edit]