ZNF217

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ZNF217
Available structures
PDB Human UniProt search: PDBe RCSB
Identifiers
Aliases ZNF217, ZABC1, zinc finger protein 217
External IDs MGI: 2685408 HomoloGene: 4757 GeneCards: 7764
RNA expression pattern
PBB GE ZNF217 203739 at tn.png
More reference expression data
Orthologs
Species Human Mouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_006526

NM_001033299
NM_001159683

RefSeq (protein)

NP_006517.1

n/a

Location (UCSC) Chr 20: 53.57 – 53.61 Mb Chr 2: 170.11 – 170.15 Mb
PubMed search [1] [2]
Wikidata
View/Edit Human View/Edit Mouse

Zinc finger protein 217, also known as ZNF217, is a protein which in humans is encoded by the ZNF217 gene.[3][4]

Function[edit]

ZNF217 can attenuate apoptotic signals resulting from telomere dysfunction and may promote neoplastic transformation and later stages of malignancy.[5] Znf217 was shown to be a prognostic biomarker and therapeutic target during breast cancer progression.[6]

See also[edit]

References[edit]

  1. ^ "Human PubMed Reference:". 
  2. ^ "Mouse PubMed Reference:". 
  3. ^ Collins C, Rommens JM, Kowbel D, Godfrey T, Tanner M, Hwang SI, Polikoff D, Nonet G, Cochran J, Myambo K, Jay KE, Froula J, Cloutier T, Kuo WL, Yaswen P, Dairkee S, Giovanola J, Hutchinson GB, Isola J, Kallioniemi OP, Palazzolo M, Martin C, Ericsson C, Pinkel D, Albertson D, Li WB, Gray JW (Jul 1998). "Positional cloning of ZNF217 and NABC1: genes amplified at 20q13.2 and overexpressed in breast carcinoma". Proceedings of the National Academy of Sciences of the United States of America. 95 (15): 8703–8. doi:10.1073/pnas.95.15.8703. PMC 21140free to read. PMID 9671742. 
  4. ^ "Entrez Gene: ZNF217 zinc finger protein 217". 
  5. ^ Huang G, Krig S, Kowbel D, Xu H, Hyun B, Volik S, Feuerstein B, Mills GB, Stokoe D, Yaswen P, Collins C (Nov 2005). "ZNF217 suppresses cell death associated with chemotherapy and telomere dysfunction". Human Molecular Genetics. 14 (21): 3219–25. doi:10.1093/hmg/ddi352. PMID 16203743. 
  6. ^ Littlepage LE, Adler AS, Kouros-Mehr H, Huang G, Chou J, Krig SR, Griffith OL, Korkola JE, Qu K, Lawson DA, Xue Q, Sternlicht MD, Dijkgraaf GJ, Yaswen P, Rugo HS, Sweeney CA, Collins CC, Gray JW, Chang HY, Werb Z (Jul 2012). "The transcription factor ZNF217 is a prognostic biomarker and therapeutic target during breast cancer progression". Cancer Discovery. 2 (7): 638–51. doi:10.1158/2159-8290.CD-12-0093. PMC 3546490free to read. PMID 22728437. 

Further reading[edit]

External links[edit]