ZNF346

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ZNF346
Available structures
PDB Ortholog search: PDBe RCSB
Identifiers
Aliases ZNF346, JAZ, Zfp346, zinc finger protein 346
External IDs MGI: 1349417 HomoloGene: 8073 GeneCards: 23567
Orthologs
Species Human Mouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_012017

RefSeq (protein)

NP_001295142.1
NP_001295143.1
NP_001295148.1
NP_001295152.1
NP_036411.1

NP_036147.1

Location (UCSC) Chr 5: 177.02 – 177.08 Mb Chr 13: 55.11 – 55.13 Mb
PubMed search [1] [2]
Wikidata
View/Edit Human View/Edit Mouse

Zinc finger protein 346 is a protein that in humans is encoded by the ZNF346 gene.[1][2]

The protein encoded by this gene is a nucleolar, zinc finger protein that preferentially binds to double-stranded (ds) RNA or RNA/DNA hybrids, rather than DNA alone. Mutational studies indicate that the zinc finger domains are not only essential for dsRNA binding, but are also required for its nucleolar localization. The encoded protein may be involved in cell growth and survival.[2]

References[edit]

  1. ^ Yang M, May WS, Ito T (Nov 1999). "JAZ requires the double-stranded RNA-binding zinc finger motifs for nuclear localization". J Biol Chem 274 (39): 27399–406. doi:10.1074/jbc.274.39.27399. PMID 10488071. 
  2. ^ a b "Entrez Gene: ZNF346 zinc finger protein 346". 

Further reading[edit]

External links[edit]

This article incorporates text from the United States National Library of Medicine, which is in the public domain.