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Zinc finger protein 384
Symbols ZNF384 ; CAGH1; CAGH1A; CIZ; ERDA2; NMP4; NP; TNRC1
External IDs OMIM609951 MGI2443203 HomoloGene15849 GeneCards: ZNF384 Gene
RNA expression pattern
PBB GE ZNF384 212369 at tn.png
More reference expression data
Species Human Mouse
Entrez 171017 269800
Ensembl ENSG00000126746 ENSMUSG00000038346
UniProt Q8TF68 E9Q1A5
RefSeq (mRNA) NM_001039916 NM_001252083
RefSeq (protein) NP_001035009 NP_001239012
Location (UCSC) Chr 12:
6.67 – 6.69 Mb
Chr 6:
125.01 – 125.04 Mb
PubMed search [1] [2]

Zinc finger protein 384 is a protein that in humans is encoded by the ZNF384 gene.[1][2][3]


This gene encodes a C2H2-type zinc finger protein, which may function as a transcription factor. This gene also contains long CAG trinucleotide repeats that encode consecutive glutamine residues. The protein appears to bind and regulate the promoters of the extracellular matrix genes MMP1, MMP3, MMP7 and COL1A1. Studies in mouse suggest that ZNF384 may be part of a general mechanical pathway that couples cell construction and function during extracellular matrix remodeling. Alternative splicing results in multiple transcript variants.[3]

Clinical significance[edit]

Recurrent rearrangements of this gene with the Ewing's sarcoma gene, EWSR1 on chromosome 22, or with the TAF15 gene on chromosome 17, or with the TCF3 (E2A) gene on chromosome 19, have been observed in acute leukemia.[3]


  1. ^ Margolis RL, Abraham MR, Gatchell SB, Li SH, Kidwai AS, Breschel TS, Stine OC, Callahan C, McInnis MG, Ross CA (Jul 1997). "cDNAs with long CAG trinucleotide repeats from human brain". Human Genetics 100 (1): 114–22. doi:10.1007/s004390050476. PMID 9225980. 
  2. ^ Thunyakitpisal P, Alvarez M, Tokunaga K, Onyia JE, Hock J, Ohashi N, Feister H, Rhodes SJ, Bidwell JP (Jan 2001). "Cloning and functional analysis of a family of nuclear matrix transcription factors (NP/NMP4) that regulate type I collagen expression in osteoblasts". Journal of Bone and Mineral Research 16 (1): 10–23. doi:10.1359/jbmr.2001.16.1.10. PMID 11149472. 
  3. ^ a b c "Entrez Gene: ZNF384 zinc finger protein 384". 

Further reading[edit]

  • Matsuo MY, Asakawa S, Shimizu N, Kimura H, Nonaka M (Feb 2002). "Nucleotide sequence of the MHC class I genomic region of a teleost, the medaka (Oryzias latipes)". Immunogenetics 53 (10-11): 930–40. doi:10.1007/s00251-001-0427-3. PMID 11862394. 
  • Graflund M, Sorbe B, Karlsson M (May 2002). "MIB-1, p53, bcl-2, and WAF-1 expression in pelvic lymph nodes and primary tumors in early stage cervical carcinomas: correlation with clinical outcome". International Journal of Oncology 20 (5): 1041–7. doi:10.3892/ijo.20.5.1041. PMID 11956602. 
  • Martini A, La Starza R, Janssen H, Bilhou-Nabera C, Corveleyn A, Somers R, Aventin A, Foà R, Hagemeijer A, Mecucci C, Marynen P (Oct 2002). "Recurrent rearrangement of the Ewing's sarcoma gene, EWSR1, or its homologue, TAF15, with the transcription factor CIZ/NMP4 in acute leukemia". Cancer Research 62 (19): 5408–12. PMID 12359745. 
  • Suzuki Y, Yamashita R, Shirota M, Sakakibara Y, Chiba J, Mizushima-Sugano J, Nakai K, Sugano S (Sep 2004). "Sequence comparison of human and mouse genes reveals a homologous block structure in the promoter regions". Genome Research 14 (9): 1711–8. doi:10.1101/gr.2435604. PMC 515316. PMID 15342556. 
  • La Starza R, Aventin A, Crescenzi B, Gorello P, Specchia G, Cuneo A, Angioni A, Bilhou-Nabera C, Boqué C, Foà R, Uyttebroeck A, Talmant P, Cimino G, Martelli MF, Marynen P, Mecucci C, Hagemeijer A (Sep 2005). "CIZ gene rearrangements in acute leukemia: report of a diagnostic FISH assay and clinical features of nine patients". Leukemia 19 (9): 1696–9. doi:10.1038/sj.leu.2403842. PMID 15990865. 
  • Janssen H, Marynen P (Apr 2006). "Interaction partners for human ZNF384/CIZ/NMP4--zyxin as a mediator for p130CAS signaling?". Experimental Cell Research 312 (7): 1194–204. doi:10.1016/j.yexcr.2006.02.001. PMID 16510139. 

External links[edit]

This article incorporates text from the United States National Library of Medicine, which is in the public domain.