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Zapotec (English: //) or zapoteca may refer to:
Cultures and languages
- Zapotec civilization, a historical indigenous pre-Columbian civilization and archaeological culture of central Mexico
- Zapotec languages, a group of closely related indigenous Mesoamerican languages
- Zapotec peoples, contemporary indigenous peoples of Mexico
- Zapotecan languages, a group of related Oto-Manguan languages (including Zapotec languages), of central Mesoamerica
- Zapoteca (plant), a legume genus
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