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Zena Werb

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Zena Werb
Born1945 (age 78–79)
Germany
Alma mater
Known forStudy of the extracellular matrix
AwardsE.B. Wilson Medal, 2007
Scientific career
FieldsCell biology
InstitutionsUniversity of California, San Francisco
Thesis Dynamics of macrophage membrane cholesterol  (1971)
Doctoral advisorZanvil Cohn
Websitewerblab.ucsf.edu

Zena Werb (born 1945) is a professor and the Vice Chair of Anatomy at the University of California, San Francisco. She is also the co-leader of the Cancer, Immunity, and Microenvironment Program at the Hellen Diller Family Comprehensive Cancer Center and a member of the Executive Committee of the Sabre-Sandler Asthma Basic Research Center at UCSF.[1][2] Her research focuses on features of the microenvironment surrounding cells, with particular interest in the extracellular matrix and the role of its protease enzymes in cell signaling.[3]

Early life and education

Werb was born in Germany in 1945. Her Polish-Jewish post-war refugee family lived in Poland and Italy before emigrating to Canada in 1948, where Werb was raised on a farm in Ontario.[4][5]

Werb received her B.Sc. in Biochemistry from the University of Toronto in 1966, having changed her major from geophysics after being told there were no accommodations for women at a field site.[4][6] She received her Ph.D. in Cell Biology from Rockefeller University in 1971, working under the supervision of Zanvil Cohn on a thesis titled "Dynamics of macrophage membrane cholesterol".[7] After graduation she worked at the Strangeways Research Laboratory in Cambridge, United Kingdom as a postdoctoral fellow with John T. Dingle from 1971 to 1973 and as a research associate from 1973 to 1975.[2][5][8]

Academic career

Werb spent a year as a visiting assistant professor at Dartmouth Medical School in New Hampshire before moving to the University of California, San Francisco in 1976, where she became a full professor in 1983.[2][5][8] She served as president of the American Society for Cell Biology in 2004.[9] She has spoken of the value of academic sabbaticals and in 2007 she spent a sabbatical at the Max Planck Institute through an Alexander von Humboldt Research Award.[10][11]

Werb has written and given interviews on her experiences as a woman in science, describing the environment in which she trained as sexist and noting that, despite improvements in women's representation in the sciences since her training, sexism "has gone underground"[4] and low representation of women in top positions remains a problem.[12][13]

Awards and honors

Werb received a Guggenheim Fellowship in 1985-6.[5] In 1996 she was awarded the FASEB Excellence in Science Award from the Federation of American Societies for Experimental Biology[11] and in 2001 she was awarded the American Association for Cancer Research Women in Cancer Research Charlotte Friend Memorial Lectureship and the UCSF Annual Faculty Research Lectureship.[14][15] The American Society for Cell Biology awarded Werb and Richard O. Hynes its most prestigious award, the E.B. Wilson Medal, in 2007.[16] In 2010 she received the Lifetime Achievement Award from Women in Cell Biology, an ASCB subgroup.[17] In 2015 she received the UCSF Lifetime Achievement in Mentoring Award.[18]

Werb was elected a fellow of the American Academy of Arts and Sciences in 2003 and a member of the United States National Academy of Sciences in 2010.[11]

Research

Werb's research group studies the effects on cells of the extracellular matrix microenvironment and its component proteases, particularly matrix metalloproteinases. The group also investigates the role of these effects on biological processes such as stem cell maturation and neoplasia, for which they use breast cancer in mice as a model.[3][6] Her work in establishing the active role of the ECM in normal cell signaling and in cancer progression is widely recognized as highly influential.[5][19]

References

  1. ^ "About Cancer, Immunity, and Microenvironment". University of California, San Francisco. Retrieved 4 July 2015.
  2. ^ a b c "Zena Werb, Ph.D." University of California, San Francisco. Retrieved 4 July 2015.
  3. ^ a b "Research". Werb Lab. University of California, San Francisco. Retrieved 4 July 2015.
  4. ^ a b c Watt, F. M. (22 February 2004). "Zena Werb". Journal of Cell Science. 117 (6): 803–804. doi:10.1242/jcs.01031.
  5. ^ a b c d e "ASCB Profiles" (PDF). American Society for Cell Biology. Retrieved 4 July 2015.
  6. ^ a b Kain, K. H. (10 August 2010). "The extracellular matrix and disease: an interview with Zena Werb". Disease Models & Mechanisms. 3 (9–10): 513–516. doi:10.1242/dmm.006338.
  7. ^ As cited in: Werb, Zena; Cohn, Zanvil A. (1971). "Cholesterol metabolism in the macrophage. I. The regulation of cholesterol exchange". The Journal of Experimental Medicine. 134 (6): 1545–69. doi:10.1084/jem.134.6.1545. PMID 5126640.
  8. ^ a b "Zena Werb". Werb Lab. University of California, San Francisco. Retrieved 4 July 2015.
  9. ^ "ASCB Presidents". American Society for Cell Biology. Retrieved 4 July 2015.
  10. ^ Hoag, Hannah (16 August 2007). "The seven-year itch". Nature. 448 (7155): 834–835. doi:10.1038/nj7155-834a.
  11. ^ a b c "Zena Werb, Ph.D." UCSF Helen Diller Family Comprehensive Cancer Center. Retrieved 4 July 2015.
  12. ^ Neugebauer, Karla M. (2006). "Keeping Tabs on the Women: Life Scientists in Europe". PLoS Biology. 4 (4): e97. doi:10.1371/journal.pbio.0040097.{{cite journal}}: CS1 maint: unflagged free DOI (link)
  13. ^ Werb, Z. (15 November 2010). "The Joy of a Career in Cell Biology". Molecular Biology of the Cell. 21 (22): 3764–3766. doi:10.1091/mbc.E10-05-0413.
  14. ^ "ASCB Newsletter". American Society for Cell Biology. 5 May 2001. Retrieved 4 July 2015.
  15. ^ "AACR-Women in Cancer Research Charlotte Friend Memorial Lectureship Recipients". American Association for Cancer Research. Retrieved 4 July 2015.
  16. ^ "E.B. Wilson Medal". American Society for Cell Biology. Retrieved 4 July 2015.
  17. ^ "WICB Awards". American Society for Cell Biology. Retrieved 4 July 2015.
  18. ^ "Zena Werb receives UCSF 2015 Mentoring Award". Department of Anatomy. University of California, San Francisco. 10 April 2015. Retrieved 4 July 2015.
  19. ^ Egeblad, M; Werb, Z (March 2002). "New functions for the matrix metalloproteinases in cancer progression". Nature reviews. Cancer. 2 (3): 161–74. doi:10.1038/nrc745. PMID 11990853.
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