ZhuZhu Pets were created by Russ Hornsby for his St. Louis company, Cepia LLC. The name comes from Mandarin zhūzhū (Chinese: 猪猪), meaning "little pig." In late 2009 Cepia employed only 16 people in the U.S. and 30 in China.
The original ZhuZhu Pets are nine different characters, with names including Chunk, PipSqueak, Mr. Squiggles, and Num Nums. There are various accessories for creating customized hamster habitats. ZhuZhu Pets can be put in either of two play modes: "nurturing mode," in which they coo and purr, or "adventure mode," in which they explore their habitat and respond to various stimuli.
In December 2009, testing done by the consumer organisation GoodGuide was initially thought to have found more than the allowed level of the toxic, silvery metalloid antimony in the Mr. Squiggles toy. After a review, regulators from the U.S. Consumer Product Safety Commission said that the toy was within the "very protective" standard. GoodGuide subsequently issued an apology saying that their testing methods (which checked for surface toxins) were different from the federal standards (which check for soluble toxins.)
Cepia encourages collecting of ZhuZhu Pets. Exclusive pets have been released in collaboration with Hallmark, Build-A-Bear Workshop, and Toys "R" Us. In early 2010 a set of new characters was released, including the Rockstar pets (Roxie, Ryder, Pax, and Kingston), inspired by the children of celebrities such as Angelina Jolie and Gwen Stefani. In mid-2010 the Kung Zhu line of battling hamsters was released, aimed at boys age 8–12. In December 2010 the ZhuZhu Princess series was released, as was a line of sixteen Burger King toys. Also released in 2010 were the first edition of ZhuZhu Babies, which are not electronic or plush, but plastic toys articulated with a small ball under their belly. The second 2011 edition of ZhuZhu Babies included motors. A clone of Zhu Zhu Pets emerged during 2010 called Furry Frenzies, which featured other animals. This inspired Zhu Zhu Pets to release non-hamster spinoff lines starting in 2011 when several dog breeds of Zhu Zhu Puppies were introduced. They are plush robotic puppies that move around and bark. In 2012, a safari line called Zhufari, a line of ponies called Zhu Zhu Ponies, and four Happy meal toys were released that were based off Quest for Zhu that were only sold in some countries excluding The U.S. The franchise was quietly discontinued sometime in 2013.
Zhu Zhu Pets was rebooted when an animated series, now known as The ZhuZhus, debuted as "Polly and the ZhuZhu Pets" on September 12, 2016 on the Disney Channel in the United States. Starting February 2017, Spin Master showcased the ZhuZhu Pets franchise in a toy fair with new toy designs, based more on the TV series.
In 2010 the first ZhuZhu Pets video game was released for Nintendo DS, iPhone, and PC. The sequel, ZhuZhu Pets 2: Featuring The Wild Bunch, was also released for Nintendo DS  and Wii, as well as ZhuZhu Pets: Kung Zhu for Nintendo DS. In 2011 ZhuZhu Princess: Carriages & Castles and ZhuZhu Puppies were released for Nintendo DS.
On September 27, 2011, the franchise's first full-length feature film Quest for Zhu was released straight-to-DVD. A second full-length feature film, The Power of Zhu, appeared to be in the works, potentially being released on DVD sometime in 2012. However, as of February 2014, no other films or even plans for films have been released for "The Power of Zhu", although it was "secretly distributed" to TV stations in France and Brazil under the title "Amazing Adventures of Zhu".
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- Spin Master (September 13, 2016). "Spin Master and Cepia, LLC Sign Global Distribution Partnership".
- "Zhu Zhu Puppies Release Information for DS". GameFAQs. March 29, 2011. Retrieved May 18, 2011.
- "Zhu Zhu Pets Release Information for iPhone/iPod". GameFAQs. November 11, 2009. Retrieved May 18, 2011.
- "Zhu Zhu Pets Release Information for PC". GameFAQs. March 23, 2010. Retrieved May 18, 2011.
- "ZhuZhu Pets 2: Featuring The Wild Bunch Release Information for DS". GameFAQs. October 12, 2010. Retrieved May 18, 2011.
- "ZhuZhu Pets: Featuring The Wild Bunch Release Information for Wii". GameFAQs. October 12, 2010. Retrieved May 18, 2011.
- "Zhu Zhu Pets: Kung Zhu Release Information for DS". GameFAQs. November 16, 2010. Retrieved May 18, 2011.
- "Zhu Zhu Princess: Carriages & Castles Release Information for DS". GameFAQs. February 8, 2011. Retrieved May 18, 2011.
- Gardner, Eriq (August 3, 2015). "Universal Sued for "Secretly" Distributing Children's Film Overseas". Hollywood Reporter. Retrieved January 2, 2018.
Through its own investigation, Cepia learned that Universal International had distributed the Amazing Adventures of Zhu to at least two television broadcasters without Cepia's knowledge or approval." Cepia adds that the "unilateral actions were especially harmful" because the television airings in Brazil and France "destroyed the potential DVD/Blu-Ray market" and further, "led to its availability on the Internet for free download.