Zinc-activated ion channel

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ZACN
Identifiers
Aliases ZACN, L2, LGICZ, LGICZ1, ZAC, ZAC1, Zinc-activated ion channel, zinc activated ion channel
External IDs HomoloGene: 52296 GeneCards: 353174
Orthologs
Species Human Mouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_180990

n/a

RefSeq (protein)

NP_851321.2

n/a

Location (UCSC) Chr 17: 76.07 – 76.08 Mb n/a
PubMed search [1] n/a
Wikidata
View/Edit Human

Zinc-activated ion channel (ZAC), is a human protein encoded by the ZACN gene. ZAC forms a cation-permeable ligand-gated ion channel of the "Cys-loop" superfamily. The ZAC gene is present in humans and dogs, but no ortholog is thought to exist in the rat or mouse genomes.[1]

ZAC mRNA is expressed in prostate, thyroid, trachea, lung, brain (adult and fetal), spinal cord, skeletal muscle, heart, placenta, pancreas, liver, kidney and stomach.[1][2] The endogenous ligand for ZAC is thought to be Zn2+, although ZAC has also been found to activate spontaneously. The function of spontaneous ZAC activation is unknown.[1]

References[edit]

  1. ^ a b c Davies PA, Wang W, Hales TG, Kirkness EF (2003). "A novel class of ligand-gated ion channel is activated by Zn2+". J. Biol. Chem. 278 (2): 712–7. doi:10.1074/jbc.M208814200. PMID 12381728. 
  2. ^ Houtani T, Munemoto Y, Kase M, Sakuma S, Tsutsumi T, Sugimoto T (2005). "Cloning and expression of ligand-gated ion-channel receptor L2 in central nervous system". Biochem Biophys Res Commun 335 (2): 227–85. doi:10.1016/j.bbrc.2005.07.079. PMID 16083862.