Zincke nitration

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Zincke nitration
Named after Theodor Zincke
Reaction type Substitution reaction
RSC ontology ID RXNO:0000413

The Zincke nitration is an organic reaction in which a bromine substituent of a phenol or cresol is replaced by a nitro group by treatment with nitrous acid or sodium nitrite.[1][2] The reaction is a manifestation of nucleophilic aromatic substitution. The reaction is named after Theodor Zincke.

Two examples:[3]

Zincke nitration


Zincke nitration

The Zincke nitration should not be confused with the Zincke–Suhl reaction or the Zincke reaction.

See also[edit]


  1. ^ Zincke, Th. (1900). "Ueber die Einwirkung von salpetriger Säure auf Brom- und Chlorderivate von Phenolen". J. Prakt. Chem. (in German). 61 (1): 561–567. doi:10.1002/prac.19000610145. 
  2. ^ Zincke, Th. (1900). "Ueber die Einwirkung von Salpetersäure auf Halogenderivate des p-Kresols". J. Prakt. Chem. (in German). 63 (1): 183–187. doi:10.1002/prac.19010630111. 
  3. ^ Raiford, L. Chas.; LeRosen, Arthur L. (1944). "The Nitration of Brominated Fluorophenols by the Zincke Method". J. Am. Chem. Soc. 66 (11): 1872–1873. doi:10.1021/ja01239a020. 
  4. ^ Raiford, L. Chas.; Miller, Glen R. (1933). "Behavior of Mixed Halogenated Phenols in the Zincke Method of Nitration". J. Am. Chem. Soc. 55 (5): 2125–2131. doi:10.1021/ja01332a059.