Perry was born in Chicago to actors Laurie Metcalf and Jeff Perry. Her first television role was two appearances as Jackie Harris (as seen in flashback) on the ABC sitcom Roseanne, the character portrayed by her mother. Her parents, however, did not want her to pursue acting until she became an adult, fearing the effect of stress. Perry said she was too shy to act in high school, but began performing at Northwestern University, as a way to make friends after transferring from Boston University.
After graduating, Perry moved to New York to search for television work, landing small roles on series such as Law & Order: Criminal Intent, but homesickness brought her back to California, where she found theater work. In 2013, she performed in The Other Place on Broadway alongside her mother. In 2015 she performed alongside her father and Kevin McKidd in Eugene O'Neill's Pulitzer Prize-winning drama Anna Christie at the Odyssey Theatre Ensemble in West Los Angeles.
Perry appeared in nine episodes of the ABC thriller The Family in 2016. In 2017, she had a recurring role on the ABC political thriller Scandal, starring her father. The same year, she was cast as a younger version of Mary Cooper (Sheldon Cooper's mother) on Young Sheldon, a spin-off of the CBS sitcom The Big Bang Theory, again portraying a younger version of her mother's role. Despite her family link to the character, she received the role through an audition.
In December 2018, Perry was nominated for a Critics' Choice Television Award for Best Supporting Actress in a Comedy Series, as was her mother for her role in The Conners; the award went to Alex Borstein for The Marvelous Mrs. Maisel.
|1992||My Thing of Love||Steppenwolf Theatre Company|
|1998||Pot Mom||Lorraine||Steppenwolf Theatre Company|
|2006||The Late Christopher Bean||Susan Haggett||The Actors Company Theatre Studio|
|2010||The Lieutenant of Inishmore||Mairead||Mark Taper Forum|
|2010||The Autumn Garden||Sophie Tuckerman||The Antaeus Company|
|2011||End Days||Rachel Stein||Odyssey Theatre Ensemble|
|2011||Peace in Our Time||Lilly Blake||The Antaeus Company|
|2012-2013||The Other Place||The Women||Samuel J. Friedman Theatre|
|2013||Good Television||Brittany||Atlantic Theater Company|
|2014||The Way West||Manda||Steppenwolf Theatre Company|
|2015||Anna Christie||Anna||Odyssey Theatre Ensemble|
|2015||I'll Get You Back Again||Staged Reading||Steppenwolf Theatre Company|
|2005||Allegretto '75||Meredith Brooke||Short film|
|2008||The Loss of a Teardrop Diamond||Mathilde|
|2016||No Pay, Nudity||Renie|
|1992, 1995||Roseanne||Young Jackie||2 episodes|
|2006||Law & Order: Criminal Intent||Wendy||Episode: "Vacancy"|
|2006||Conviction||Audrey Knowles||2 episodes|
|2006, 2008, 2010||My Boys||Waitress||4 episodes|
|2007||Cold Case||Melinda Levy '82||Episode: "Justice"|
|2008||Private Practice||Lisa||Episode: "Equal & Opposite"|
|2009||Ave 43||Janet||2 episodes|
|2012||Grey's Anatomy||Katy Noonan||Episode: "Beautiful Doom"|
|2013||Second Shot||Krystal Munson||Episode: "If It Ain't Fix, Don't Break It"|
|2016||The Family||Jane||9 episodes|
|2016||NCIS||Harpers Ferry Police Officer Kristen Fields||2 episodes|
|2017||Liv and Maddie||Marlow||Episode: "Tiny House-A-Rooney"|
|2017||Scandal||Samantha Ruland||9 episodes|
|2017–present||Young Sheldon||Mary Cooper||Main cast|
- Metz, Nina. ""Zoe Perry plays her mother Laurie Metcalf on 'Young Sheldon'...sort of"". chicagotribune.com. Retrieved 11 September 2018.
- ""Today's Briefings"". Chicago Tribune. September 27, 1983. Retrieved September 11, 2018.
- Dowling, Amber (June 22, 2017). "'Young Sheldon': How Zoe Perry Plans to Walk in Her Mother's Emmy-Nominated Shoes". Hollywood Reporter. Retrieved September 29, 2017.
- Gomez, Patrick (September 15, 2017). "Inside the Crazy Family Connection Between the Stars Playing Sheldon's Mom on Big Bang Theory & Young Sheldon". People. Retrieved September 27, 2017.
- Gilbert, Ryan (January 17, 2013). "The Other Place's Zoe Perry on the 'Surreal' Joy of Co-Starring on Broadway With Her Mom, Laurie Metcalf". Broadway. Retrieved September 29, 2017.
- King, Susan (January 21, 2015). "'Anna Christie' a new stage in Jeff Perry, daughter Zoe's relationship". Los Angeles Times. Retrieved September 23, 2019.
- "Zoe Perry". TV Guide. Retrieved 6 October 2017.
- Abrams, Natalie (April 29, 2017). "The Big Bang Theory spinoff star Zoe Perry on emulating her mom, Laurie Metcalf". Entertainment Weekly. Retrieved September 29, 2017.
- "Critics' Choice Awards winners: See who won big in 2019". ABC. January 13, 2019. Retrieved September 23, 2019.
- "'The Loss of a Teardrop Diamond' from 'Lost' Tennessee Williams Screenplay: Q&A with Director Jodie Markell". Alt Film Guide. Retrieved 24 April 2018.
- "'No Pay, Nudity': Film Review". Hollywood Reporter. 11 November 2016. Retrieved 24 April 2018.