Pier Donato Cesi (1521–1586)
- Not to be confused with his relative, Pier Donato Cesi, iuniore (1583–1656).
Pier Donato Cesi (1521–1586) was an Italian Catholic Cardinal. He is sometimes referred to as Pier Donato Cesi, seniore (senior) to differentiate between him and his relative Pier Donato Cesi iuniore (1583–1656).
He bought in 1565 together with his brother Cardinal Ottavio Cesi, bishop of Todi, the Palazzo Armellini in Borgo, and took charge of the restructuring, relying for the new project to Martino Longhi the Elder, who between 1570 and 1588 oversaw the renovation in its present form. Being like his brother an art lover, he hosted in his palace a large antiques collection and a large library.
Cesi was nominated at the Papal conclave of 1585 but was not elected.