Nikolay Fyodorovich Gamaleya (Russian: Никола́й Фёдорович Гамале́я; 17 February 1859 [O.S. 5 February] – 29 March 1949) was a Russian and Soviet physician and scientist who played a pioneering role in microbiology and vaccine research.
Gamaleya was born in Odessa, then part of the Russian Empire in noble family of Zaporozhian Cossack origin. He graduated from Odessa's Novorossiysky University (now Odessa University) in 1880 and the St. Petersburg Military Medical Academy (now the S. M. Kirov Military Medical Academy) in 1883. He became a respected hospital physician in his native Odessa afterward.
Gamaleya worked in Louis Pasteur's laboratory in France in 1886. Following Pasteur's model after his return, he joined Ilya Mechnikov in organizing an Odessa bacteriological station for rabies vaccination studies and research on combating cattle plague and cholera, diagnosing sputum for tuberculosis, and preparing anthrax vaccines. The Odessa Bacteriological Institute became Russia's first-ever bacteriological observation station.
Despite the poor facilities and the small staff, the scientists were able to succeed in figuring out the conditions under which the rabies vaccination was most effective. Gamaleya's proposal for using killed bacilli in anti-cholera vaccines was later successfully applied on a wide scale as well. Similar stations were soon founded in Kiev (1886), Yekaterinoslav (1897), and Chernigov (1897).
After defending his 1892 dissertation on the etiology of cholera (published in 1893), Gamaleya served as director of the Odessa Bacteriological Institute in 1896-1908. Reporting of the lysis of Bacillus anthracis bacteria by a transmissible "ferment" in 1898, Gamaleya was the discoverer of the bacteria-destroying antibodies known as bacteriolysins.
Gamaleya initiated a public health campaign of exterminating rats to fight the plague in Odessa and southern Russia and pointed to the louse as the carrier of typhus. In 1910-1913, Gamaleya edited the journal Gigiena i sanitaria (Hygiene and Medicine).
The author of more than 300 academic publications on bacteriology, Gamaleya was a member of the Academy of Sciences of the USSR and the USSR Academy of Medical Sciences. He also served as head of the All-Union Society of Microbiologists, Epidemiologists and Infectionists.
Gamaleya died in Moscow.
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- Melikishvili, Alexander (2006). "Genesis of the Anti-Plague System: The Tsarist Period". Critical Reviews in Microbiology 32, pp. 19–31. ISSN 1040-841X.
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- Podolsky, Edward (1972). Red Miracle: The Story of Soviet Medicine. New York: Beechhurst Press. p. 222. ISBN 0-8369-2818-0.
- Podolsky, Edward (1972). Red Miracle: The Story of Soviet Medicine. New York: Beechhurst Press. p. 224. ISBN 0-8369-2818-0.
- Bardell, D (1982). "An 1898 Report by Gamaleya for a Lytic Agent Specific for Bacillus Anthracis". Journal of the History of Medicine and Allied Sciences. 37 (2): 222–5. doi:10.1093/jhmas/xxxvii.2.222. PMID 6806352.
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