Ephrin-A2 is a protein that in humans is encoded by the EFNA2gene.[5]
This gene encodes a member of the ephrin family. The protein is composed of a signal sequence, a receptor-binding region, a spacer region, and a hydrophobic region. The EPH and EPH-related receptors comprise the largest subfamily of receptor protein-tyrosine kinases and have been implicated in mediating developmental events, particularly in the nervous system. Based on their structures and sequence relationships, ephrins are divided into the ephrin-A (EFNA) class, which are anchored to the membrane by a glycosylphosphatidylinositol linkage, and the ephrin-B (EFNB) class, which are transmembrane proteins. Posttranslational modifications determine whether this protein localizes to the nucleus or the cytoplasm.[5]
Holder N, Klein R (1999). "Eph receptors and ephrins: effectors of morphogenesis". Development. 126 (10): 2033–44. doi:10.1242/dev.126.10.2033. PMID10207129.
Cerretti DP, Nelson N (1998). "Characterization of the genes for mouse LERK-3/Ephrin-A3 (Epl3), mouse LERK-4/Ephrin-A4 (Epl4), and human LERK-6/Ephrin-A2 (EPLG6): conservation of intron/exon structure". Genomics. 47 (1): 131–5. doi:10.1006/geno.1997.5088. PMID9465306.
Ciossek T, Monschau B, Kremoser C, Loschinger J, Lang S, Muller BK, Bonhoeffer F, Drescher U (1998). "Eph receptor-ligand interactions are necessary for guidance of retinal ganglion cell axons in vitro". Eur. J. Neurosci. 10 (5): 1574–80. doi:10.1046/j.1460-9568.1998.00180.x. PMID9751130. S2CID20470923.
Aasheim HC, Pedeutour F, Grosgeorge J, Logtenberg T (1998). "Cloning, chromosal mapping, and tissue expression of the gene encoding the human Eph-family kinase ligand ephrin-A2". Biochem. Biophys. Res. Commun. 252 (2): 378–82. doi:10.1006/bbrc.1998.9618. PMID9826538.
Rodger J, Lindsey KA, Leaver SG, King CE, Dunlop SA, Beazley LD (2002). "Expression of ephrin-A2 in the superior colliculus and EphA5 in the retina following optic nerve section in adult rat". Eur. J. Neurosci. 14 (12): 1929–36. doi:10.1046/j.0953-816x.2001.01822.x. PMID11860487. S2CID24040732.