OR12D3

OR12D3
Identifiers
Aliases	OR12D3, hs6M1-27, olfactory receptor family 12 subfamily D member 3
External IDs	MGI: 2177492; HomoloGene: 12811; GeneCards: OR12D3; OMA:OR12D3 - orthologs
Gene location (Human) Chr. Chromosome 6 (human) Band 6p22.1 Start 29,373,423 bp End 29,375,291 bp
Gene location (Mouse) Chr. Chromosome 17 (mouse) Band 17|17 B1 Start 37,769,807 bp End 37,782,481 bp
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in testicle n/a More reference expression data BioGPS More reference expression data
Gene ontology Molecular function G protein-coupled receptor activity olfactory receptor activity transmembrane signaling receptor activity signal transducer activity Cellular component integral component of membrane plasma membrane membrane Biological process sensory perception of smell detection of chemical stimulus involved in sensory perception of smell detection of chemical stimulus involved in sensory perception signal transduction response to stimulus G protein-coupled receptor signaling pathway Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 81797 258832 Ensembl ENSG00000112462 ENSG00000250364 ENSG00000204692 ENSG00000224487 ENSG00000242022 ENSG00000251394 ENSG00000229181 ENSMUSG00000029184 UniProt Q9UGF7 Q8VG96 RefSeq (mRNA) NM_030959 NM_146835 RefSeq (protein) NP_112221 NP_667046 Location (UCSC) Chr 6: 29.37 – 29.38 Mb Chr 17: 37.77 – 37.78 Mb PubMed search
Wikidata
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Olfactory receptor 12D3 is a protein that in humans is encoded by the OR12D3 gene.

Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms.

See also

• Olfactory receptor

Further reading

• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Volz A, Ehlers A, Younger R, et al. (2003). "Complex transcription and splicing of odorant receptor genes". J. Biol. Chem. 278 (22): 19691–701. doi:10.1074/jbc.M212424200. PMID 12637542.
• Mungall AJ, Palmer SA, Sims SK, et al. (2003). "The DNA sequence and analysis of human chromosome 6". Nature. 425 (6960): 805–11. Bibcode:2003Natur.425..805M. doi:10.1038/nature02055. PMID 14574404.
• Malnic B, Godfrey PA, Buck LB (2004). "The human olfactory receptor gene family". Proc. Natl. Acad. Sci. U.S.A. 101 (8): 2584–9. Bibcode:2004PNAS..101.2584M. doi:10.1073/pnas.0307882100. PMC 356993. PMID 14983052.
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
• Santos PS, Füst G, Prohászka Z, et al. (2008). "Association of smoking behavior with an odorant receptor allele telomeric to the human major histocompatibility complex". Genet. Test. 12 (4): 481–6. doi:10.1089/gte.2008.0029. PMC 2635552. PMID 18939942.
• Santos PS, Kellermann T, Uchanska-Ziegler B, et al. (2010). "Genomic architecture of MHC-linked odorant receptor gene repertoires among 16 vertebrate species". Immunogenetics. 62 (9): 569–84. doi:10.1007/s00251-010-0468-6. PMID 20680261. S2CID 23003444.

External links

• OR12D3+protein,+human at the U.S. National Library of Medicine Medical Subject Headings (MeSH)

This article incorporates text from the United States National Library of Medicine, which is in the public domain.