STX1B

STX1B
Identifiers
Aliases	STX1B, STX1B1, STX1B2, GEFSP9, syntaxin 1B
External IDs	OMIM: 601485; MGI: 1930705; HomoloGene: 69375; GeneCards: STX1B; OMA:STX1B - orthologs
Gene location (Human)
Chr.	Chromosome 16 (human)
End	31,010,638 bp
Gene location (Mouse)
Chr.	Chromosome 7 (mouse)
End	127,423,721 bp
RNA expression pattern
	Top expressed in
	right hemisphere of cerebellum; ; right frontal lobe; ; Brodmann area 9; ; prefrontal cortex; ; cingulate gyrus; ; anterior cingulate cortex; ; postcentral gyrus; ; superior frontal gyrus; ; nucleus accumbens; ; hypothalamus;
	Top expressed in
	superior frontal gyrus; ; cerebellar cortex; ; dentate gyrus of hippocampal formation granule cell; ; pontine nuclei; ; dorsal tegmental nucleus; ; dorsomedial hypothalamic nucleus; ; cerebellar vermis; ; medial vestibular nucleus; ; lobe of cerebellum; ; subiculum;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	SNAP receptor activity; protein kinase binding; signaling receptor binding; SNARE binding; protein domain specific binding;
Cellular component	integral component of membrane; cytosol; membrane; synaptic vesicle; plasma membrane; spindle; microtubule organizing center; SNARE complex; cytoskeleton; nuclear lamina; nucleus; nucleoplasm; centrosome; cytoplasm; presynaptic membrane; presynapse; presynaptic active zone membrane; axon; neuromuscular junction; endomembrane system;
Biological process	synaptic vesicle docking; spontaneous neurotransmitter secretion; positive regulation of neurotransmitter secretion; regulation of exocytosis; vesicle docking; positive regulation of excitatory postsynaptic potential; regulation of gene expression; protein transport; intracellular protein transport; neurotransmitter transport; vesicle-mediated transport; regulation of synaptic vesicle priming; negative regulation of neuron projection development; regulation of synaptic activity; vesicle docking involved in exocytosis; calcium ion-regulated exocytosis of neurotransmitter; protein localization to membrane; negative regulation of synaptic vesicle recycling; positive regulation of spontaneous neurotransmitter secretion; negative regulation of macropinocytosis; synaptic vesicle fusion to presynaptic active zone membrane; exocytic insertion of neurotransmitter receptor to postsynaptic membrane; synaptic vesicle exocytosis; exocytosis; vesicle fusion;
	Sources:Amigo / QuickGO
Orthologs
	112755
	56216
	ENSG00000099365
	ENSMUSG00000030806
	P61266
	P61264
	NM_052874
	NM_024414
	NP_443106
	NP_077725
	Wikidata
View/Edit Human	View/Edit Mouse

Syntaxin-1B is a protein that in humans is encoded by the STX1B gene.^[5]

Interactions

STX1B has been shown to interact with UNC13B.^[6]

References

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000099365 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000030806 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Entrez Gene: STX1B2 syntaxin 1B2".
^ Betz A, Okamoto M, Benseler F, Brose N (January 1997). "Direct interaction of the rat unc-13 homologue Munc13-1 with the N terminus of syntaxin". The Journal of Biological Chemistry. 272 (4): 2520–6. doi:10.1074/jbc.272.4.2520. PMID 8999968.

Li G, Alexander EA, Schwartz JH (May 2003). "Syntaxin isoform specificity in the regulation of renal H+-ATPase exocytosis". The Journal of Biological Chemistry. 278 (22): 19791–7. doi:10.1074/jbc.M212250200. PMID 12651853.
Pérez-Brangulí F, Muhaisen A, Blasi J (June 2002). "Munc 18a binding to syntaxin 1A and 1B isoforms defines its localization at the plasma membrane and blocks SNARE assembly in a three-hybrid system assay". Molecular and Cellular Neurosciences. 20 (2): 169–80. doi:10.1006/mcne.2002.1122. PMID 12093152. S2CID 23927545.
Nagamatsu S, Nakamichi Y, Watanabe T, Matsushima S, Yamaguchi S, Ni J, Itagaki E, Ishida H (January 2001). "Localization of cellubrevin-related peptide, endobrevin, in the early endosome in pancreatic beta cells and its physiological function in exo-endocytosis of secretory granules". Journal of Cell Science. 114 (Pt 1): 219–227. doi:10.1242/jcs.114.1.219. PMID 11112705.
Betz A, Okamoto M, Benseler F, Brose N (January 1997). "Direct interaction of the rat unc-13 homologue Munc13-1 with the N terminus of syntaxin". The Journal of Biological Chemistry. 272 (4): 2520–6. doi:10.1074/jbc.272.4.2520. PMID 8999968.
Smirnova T, Miniou P, Viegas-Pequignot E, Mallet J (September 1996). "Assignment of the human syntaxin 1B gene (STX) to chromosome 16p11.2 by fluorescence in situ hybridization". Genomics. 36 (3): 551–3. doi:10.1006/geno.1996.0506. PMID 8884284.
Smirnova T, Stinnakre J, Mallet J (October 1993). "Characterization of a presynaptic glutamate receptor". Science. 262 (5132): 430–3. Bibcode:1993Sci...262..430S. doi:10.1126/science.8105537. PMID 8105537.

This article on a gene on human chromosome 16 is a stub. You can help Wikipedia by expanding it.

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000099365 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000030806 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[entrez-5] "Entrez Gene: STX1B2 syntaxin 1B2".

[pmid8999968-6] Betz A, Okamoto M, Benseler F, Brose N (January 1997). "Direct interaction of the rat unc-13 homologue Munc13-1 with the N terminus of syntaxin". The Journal of Biological Chemistry. 272 (4): 2520–6. doi:10.1074/jbc.272.4.2520. PMID 8999968.

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Interactions

References

Further reading