From Wikipedia, the free encyclopedia
Protein-coding gene in the species Homo sapiens
Carcinoembryonic antigen-related cell adhesion molecule 16 is encoded in the human by the CEACAM16 gene. It is a member of the carcinoembryonic antigen family, a cluster of genes on chromosome 19 . CEACAM16 is a structure of the tectorial membrane
involved in hearing at low and high frequencies. It is the only carcinoembryonic antigen found in the platypus .[5] hair cells , and mutations in this gene are associated with autosomal dominant nonsyndromic deafness .[6] [7]
References [ edit ]
^ a b c GRCh38: Ensembl release 89: ENSG00000213892 – Ensembl , May 2017^ a b c GRCm38: Ensembl release 89: ENSMUSG00000014686 – Ensembl , May 2017^ "Human PubMed Reference:" . National Center for Biotechnology Information, U.S. National Library of Medicine .^ "Mouse PubMed Reference:" . National Center for Biotechnology Information, U.S. National Library of Medicine .^ Kammerer R, Rüttiger L, Riesenberg R, Schäuble C, Krupar R, Kamp A, et al. (June 2012). "Loss of mammal-specific tectorial membrane component carcinoembryonic antigen cell adhesion molecule 16 (CEACAM16) leads to hearing impairment at low and high frequencies" . The Journal of Biological Chemistry . 287 (26): 21584–21598. doi :10.1074/jbc.M111.320481 PMC 3381124 PMID 22544735 . ^ Zheng J, Miller KK, Yang T, Hildebrand MS, Shearer AE, DeLuca AP, et al. (March 2011). "Carcinoembryonic antigen-related cell adhesion molecule 16 interacts with alpha-tectorin and is mutated in autosomal dominant hearing loss (DFNA4)" . Proceedings of the National Academy of Sciences of the United States of America . 108 (10): 4218–4223. Bibcode :2011PNAS..108.4218Z . doi :10.1073/pnas.1005842108 PMC 3054008 PMID 21368133 . ^ Hofrichter MA, Nanda I, Gräf J, Schröder J, Shehata-Dieler W, Vona B, Haaf T (October 2015). "A Novel de novo Mutation in CEACAM16 Associated with Postlingual Hearing Impairment" . Molecular Syndromology . 6 (4): 156–163. doi :10.1159/000439576 . PMC 4662267 PMID 26648831 .
