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Non-coding RNA in the species Homo sapiens
Colon cancer associated transcript 1 is a long non-coding RNA that, in humans, is encoded by the CCAT1 gene .[2] [3]
This gene produces a long non-coding RNA that promotes tumor formation and is upregulated in colon cancer and other cancer cell types.[4] This transcript may regulate long range chromosomal interactions, including at the Myc oncoprotein locus.[5] This RNA may also function as a molecular sponge for microRNAs .[6]
References [ edit ]
Further reading [ edit ]
Yang F, Xue X, Bi J, Zheng L, Zhi K, Gu Y, Fang G (2013). "Long noncoding RNA CCAT1, which could be activated by c-Myc, promotes the progression of gastric carcinoma". J. Cancer Res. Clin. Oncol . 139 (3): 437–45. doi :10.1007/s00432-012-1324-x . PMID 23143645 . S2CID 667876 .
Alaiyan B, Ilyayev N, Stojadinovic A, Izadjoo M, Roistacher M, Pavlov V, Tzivin V, Halle D, Pan H, Trink B, Gure AO, Nissan A (2013). "Differential expression of colon cancer associated transcript1 (CCAT1) along the colonic adenoma-carcinoma sequence" . BMC Cancer . 13 : 196. doi :10.1186/1471-2407-13-196 . PMC 3639026 . PMID 23594791 .
Xiang JF, Yin QF, Chen T, Zhang Y, Zhang XO, Wu Z, Zhang S, Wang HB, Ge J, Lu X, Yang L, Chen LL (2014). "Human colorectal cancer-specific CCAT1-L lncRNA regulates long-range chromatin interactions at the MYC locus" . Cell Res . 24 (5): 513–31. doi :10.1038/cr.2014.35 . PMC 4011346 . PMID 24662484 .
Luo J, Tang L, Zhang J, Ni J, Zhang HP, Zhang L, Xu JF, Zheng D (2014). "Long non-coding RNA CARLo-5 is a negative prognostic factor and exhibits tumor pro-oncogenic activity in non-small cell lung cancer". Tumour Biol . 35 (11): 11541–9. doi :10.1007/s13277-014-2442-7 . PMID 25129441 . S2CID 17249302 .
Ma MZ, Chu BF, Zhang Y, Weng MZ, Qin YY, Gong W, Quan ZW (2015). "Long non-coding RNA CCAT1 promotes gallbladder cancer development via negative modulation of miRNA-218-5p" . Cell Death Dis . 6 (1): e1583. doi :10.1038/cddis.2014.541 . PMC 4669740 . PMID 25569100 .
Zhang Y, Ma M, Liu W, Ding W, Yu H (2014). "Enhanced expression of long noncoding RNA CARLo-5 is associated with the development of gastric cancer" . Int J Clin Exp Pathol . 7 (12): 8471–9. PMC 4314006 . PMID 25674211 .
Cabanski CR, White NM, Dang HX, Silva-Fisher JM, Rauck CE, Cicka D, Maher CA (2015). "Pan-cancer transcriptome analysis reveals long noncoding RNAs with conserved function" . RNA Biol . 12 (6): 628–42. doi :10.1080/15476286.2015.1038012 . PMC 4615893 . PMID 25864709 .
Deng L, Yang SB, Xu FF, Zhang JH (2015). "Long noncoding RNA CCAT1 promotes hepatocellular carcinoma progression by functioning as let-7 sponge" . J. Exp. Clin. Cancer Res . 34 (1): 18. doi :10.1186/s13046-015-0136-7 . PMC 4339002 . PMID 25884472 .
Zhu H, Zhou X, Chang H, Li H, Liu F, Ma C, Lu J (2015). "CCAT1 promotes hepatocellular carcinoma cell proliferation and invasion" . Int J Clin Exp Pathol . 8 (5): 5427–34. PMC 4503117 . PMID 26191246 .