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'''Benexate''' ([[International Nonproprietary Name|INN]]) is a drug used in the treatment of acid-related disorders.
'''Benexate''' (BEX) is an anti-ulcer agent used in the treatment of acid-related disorders.


== Mechanism of action==
⚫
==References==
Promotion of prostaglandin synthesis, protein secretion, and blood flow stimulation in the gastrointestinal tract. <ref>{{cite journal | vauthors = Iwasaki, T., Matsunaga, K. | title = Drug interactions with agents used to treat acid-related diseases | journal = Drug. Dev. Res. | issue = 36 | pages = 13–19 | date = 1995| pmid = 27446246| doi = 10.3892/etm.2016.3384 }}</ref>
<references/>

[[File:Beta cyclodextrin.svg|thumb|left|BEX-HCl forms an [[Inclusion_compound|inclusion complex]] with [[Cyclodextrin|β-cyclodextrin]] to improve its solubility as well as uniquely functioning as an anti-bittering agent.<ref>{{cite journal | vauthors = Hori, Y., Odaguchi, K., Jyoyama, H., Yasui, K., Mizui, T. | title = Differential effect of benexate hydrochloride betadex on prostaglandin levels in stomach and inflammatory sites in rats. | journal = J. Pharmacol. | issue = 72 | pages = 183-190 | date = 1996| pmid = 8912919| doi = 10.1254/jjp.72.183 }}</ref><ref>{{cite journal | vauthors = Muranushi, N., Yoshida, M., Kinoshita, H., Hirose, F., Fukuda, T., Doteuchi, M., Yamada, H. | title = Studies of benexate CD: effect of inclusion compound formation on the antiulcer activity of
benexate, the effective ingredient of benexate CD. | journal = Folia Pharmacol. Jpn. | issue = 91| pages = 377-383 | date = 1998 }}</ref>]]

==See also==
{{columns-list|colwidth=30em|}}
* [[Famotidine]]
* [[Powder_diffraction|Powder diffraction]]
* [[Sugar_substitute|Artifical Sweeneters]]
* [[Crystal_engineering | Multicomponent crystals]]

⚫
== References ==
{{Reflist}}

==Further reading==
* {{Cite book |title=Advances in Organic Crystal Chemistry: Comprehensive Reviews 2015 (1st edition) |date=2015|editor=Rui Tamura, Mikiji Miyata | publisher = Springer Japan | isbn=978-4-431-55554-4 |url= https://www.springer.com/gp/book/9784431555544}}


[[Category:Drugs acting on the gastrointestinal system and metabolism]]
[[Category:Drugs acting on the gastrointestinal system and metabolism]]

Revision as of 19:14, 11 June 2021

Benexate
Clinical data
AHFS/Drugs.comInternational Drug Names
Routes of
administration		Oral
ATC code
  • none
Legal status
Legal status
  • In general: ℞ (Prescription only)
Identifiers
  • phenylmethyl 2-[4-[(diaminomethylideneamino)methyl]cyclohexanecarbonyl]oxybenzoate
CAS Number
PubChem CID
ChemSpider
UNII
ChEMBL
Chemical and physical data
FormulaC23H27N3O4
Molar mass409.486 g·mol−1
3D model (JSmol)
  • O=C(OCc1ccccc1)c3ccccc3OC(=O)C2CCC(C/N=C(\N)N)CC2
  • InChI=1S/C23H27N3O4/c24-23(25)26-14-16-10-12-18(13-11-16)21(27)30-20-9-5-4-8-19(20)22(28)29-15-17-6-2-1-3-7-17/h1-9,16,18H,10-15H2,(H4,24,25,26) checkY
  • Key:IAXUQWSLRKIRFR-UHFFFAOYSA-N checkY
 ☒NcheckY (what is this?)  (verify)

Benexate (BEX) is an anti-ulcer agent used in the treatment of acid-related disorders.

Mechanism of action

Promotion of prostaglandin synthesis, protein secretion, and blood flow stimulation in the gastrointestinal tract. [1]

BEX-HCl forms an inclusion complex with β-cyclodextrin to improve its solubility as well as uniquely functioning as an anti-bittering agent.[2][3]

See also

References

  1. ^ Iwasaki, T., Matsunaga, K. (1995). "Drug interactions with agents used to treat acid-related diseases". Drug. Dev. Res. (36): 13–19. doi:10.3892/etm.2016.3384. PMID 27446246. {{cite journal}}: Vancouver style error: non-Latin character in name 2 (help)
  2. ^ Hori, Y., Odaguchi, K., Jyoyama, H., Yasui, K., Mizui, T. (1996). "Differential effect of benexate hydrochloride betadex on prostaglandin levels in stomach and inflammatory sites in rats". J. Pharmacol. (72): 183–190. doi:10.1254/jjp.72.183. PMID 8912919. {{cite journal}}: Vancouver style error: non-Latin character in name 2 (help)
  3. ^ Muranushi, N., Yoshida, M., Kinoshita, H., Hirose, F., Fukuda, T., Doteuchi, M., Yamada, H. (1998). "Studies of benexate CD: effect of inclusion compound formation on the antiulcer activity of benexate, the effective ingredient of benexate CD". Folia Pharmacol. Jpn. (91): 377–383. {{cite journal}}: Vancouver style error: non-Latin character in name 2 (help); line feed character in |title= at position 92 (help)

Further reading

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