Myosin-IIIa

MYO3A
Identifiers
Aliases	MYO3A, myosin IIIA, DFNB30
External IDs	OMIM: 606808; MGI: 2183924; HomoloGene: 49486; GeneCards: MYO3A; OMA:MYO3A - orthologs
Gene location (Human) Chr. Chromosome 10 (human) Band 10p12.1 Start 25,934,229 bp End 26,212,532 bp
Gene location (Mouse) Chr. Chromosome 2 (mouse) Band 2|2 A3 Start 22,232,314 bp End 22,508,264 bp
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in islet of Langerhans testicle gonad sperm ventricular zone right testis left testis ganglionic eminence epithelium of colon popliteal artery Top expressed in morula embryo embryo zygote secondary oocyte tail of embryo blastocyst spermatid duodenum superior frontal gyrus More reference expression data BioGPS n/a
Gene ontology Molecular function transferase activity protein kinase activity nucleotide binding ADP binding calmodulin binding kinase activity microfilament motor activity protein serine/threonine kinase activity plus-end directed microfilament motor activity actin binding cytoskeletal motor activity ATP binding protein binding Cellular component filamentous actin filopodium cytoskeleton myosin complex cytoplasm stereocilium tip stereocilium filopodium tip cell projection Biological process phosphorylation response to stimulus protein phosphorylation protein autophosphorylation visual perception hearing cochlea morphogenesis Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 53904 667663 Ensembl ENSG00000095777 ENSMUSG00000025716 UniProt Q8NEV4 Q8K3H5 RefSeq (mRNA) NM_017433 NM_001368265 NM_148413 RefSeq (protein) NP_059129 NP_001355194 n/a Location (UCSC) Chr 10: 25.93 – 26.21 Mb Chr 2: 22.23 – 22.51 Mb PubMed search
Wikidata
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Myosin IIIA is a protein that in humans is encoded by the MYO3A gene.

The protein encoded by this gene belongs to the myosin superfamily. Myosins are actin-dependent motor proteins and are categorized into conventional myosins (class II) and unconventional myosins (classes I and III through XV) based on their variable C-terminal cargo-binding domains. Class III myosins, such as this one, have a kinase domain N-terminal to the conserved N-terminal motor domains and are expressed in photoreceptors. The protein encoded by this gene plays an important role in hearing in humans. Three different recessive, loss of function mutations in the encoded protein have been shown to cause nonsyndromic progressive hearing loss. Expression of this gene is highly restricted, with the strongest expression in retina and cochlea.

Further reading

• Walsh T, Walsh V, Vreugde S, et al. (2002). "From flies' eyes to our ears: mutations in a human class III myosin cause progressive nonsyndromic hearing loss DFNB30". Proc. Natl. Acad. Sci. U.S.A. 99 (11): 7518–23. Bibcode:2002PNAS...99.7518W. doi:10.1073/pnas.102091699. PMC 124268. PMID 12032315.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Komaba S, Inoue A, Maruta S, et al. (2003). "Determination of human myosin III as a motor protein having a protein kinase activity". J. Biol. Chem. 278 (24): 21352–60. doi:10.1074/jbc.M300757200. PMID 12672820.
• Deloukas P, Earthrowl ME, Grafham DV, et al. (2004). "The DNA sequence and comparative analysis of human chromosome 10". Nature. 429 (6990): 375–81. Bibcode:2004Natur.429..375D. doi:10.1038/nature02462. PMID 15164054.
• Fu GK, Wang JT, Yang J, et al. (2005). "Circular rapid amplification of cDNA ends for high-throughput extension cloning of partial genes". Genomics. 84 (1): 205–10. doi:10.1016/j.ygeno.2004.01.011. PMID 15203218.
• Beausoleil SA, Jedrychowski M, Schwartz D, et al. (2004). "Large-scale characterization of HeLa cell nuclear phosphoproteins". Proc. Natl. Acad. Sci. U.S.A. 101 (33): 12130–5. Bibcode:2004PNAS..10112130B. doi:10.1073/pnas.0404720101. PMC 514446. PMID 15302935.
• Barrios-Rodiles M, Brown KR, Ozdamar B, et al. (2005). "High-throughput mapping of a dynamic signaling network in mammalian cells". Science. 307 (5715): 1621–5. Bibcode:2005Sci...307.1621B. doi:10.1126/science.1105776. PMID 15761153. S2CID 39457788.
• Kambara T, Komaba S, Ikebe M (2007). "Human myosin III is a motor having an extremely high affinity for actin". J. Biol. Chem. 281 (49): 37291–301. doi:10.1074/jbc.M603823200. PMID 17012748.
• Schneider ME, Dosé AC, Salles FT, et al. (2006). "A new compartment at stereocilia tips defined by spatial and temporal patterns of myosin IIIa expression". J. Neurosci. 26 (40): 10243–52. doi:10.1523/JNEUROSCI.2812-06.2006. PMC 6674622. PMID 17021180.
• Dosé AC, Ananthanarayanan S, Moore JE, et al. (2007). "Kinetic mechanism of human myosin IIIA". J. Biol. Chem. 282 (1): 216–31. doi:10.1074/jbc.M605964200. PMID 17074769.

• Cirilo JA Jr, Gunther LK, Yengo CM. (2021). "Functional Role of Class III Myosins in Hair Cells". Front Cell Dev Biol. 9: 643856. doi:10.3389/fcell.2021.643856. PMID 33718386. {{cite journal}}: Vancouver style error: punctuation in name 3 (help)