NTN5: Difference between revisions
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←Created page with 'Netrin-5 (NTN5), also known as Netrin-1-Like Protein, is a protein that in humans is encoded by the ''NTN5'' gene<ref>{{Cite web|title=NTN5 netrin 5 [Homo sapiens (human)] - Gene - NCBI|url=https://www.ncbi.nlm.nih.gov/gene/126147|access-date=2021-12-11|website=www.ncbi.nlm.nih.gov}}</ref>. Netrin-5 is included in the family of secreted laminin-related proteins. == Function == Netrin-5 functions are not fully clarified. However, it is b...' |
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Revision as of 09:55, 11 December 2021
Netrin-5 (NTN5), also known as Netrin-1-Like Protein, is a protein that in humans is encoded by the NTN5 gene[1]. Netrin-5 is included in the family of secreted laminin-related proteins.
Function
Netrin-5 functions are not fully clarified. However, it is believed to:
- Plays an important role in neurogenesis by controlling the development of dendrites and acting as a guide for axons.[2][3]
- Regulates cell migration in the brain during embryonic development.[4]
- Prevents motor neuron cell body migration out of the neural tube.[4]
Clinical significance
A recent genome-wide association study (GWAS) has found that genetic variations in HAVCR2 are associated with late-onset sporadic Alzheimer’s disease (LOAD). However, it's unknown how netrin-5 mutation contributes to disease.[5]
Considering the role of NTN5 in cell migration, it is very possible that netrin-5 has an important role in human carcinogenesis, although currently no tumor type with NTN5 alterations has been identified.[6]
References
- ^ "NTN5 netrin 5 [Homo sapiens (human)] - Gene - NCBI". www.ncbi.nlm.nih.gov. Retrieved 2021-12-11.
- ^ Yamagishi, Satoru; Yamada, Kohei; Sawada, Masato; Nakano, Suguru; Mori, Norio; Sawamoto, Kazunobu; Sato, Kohji (2015). "Netrin-5 is highly expressed in neurogenic regions of the adult brain". Frontiers in Cellular Neuroscience. 9: 146. doi:10.3389/fncel.2015.00146. ISSN 1662-5102. PMC 4403520. PMID 25941474.
{{cite journal}}: CS1 maint: unflagged free DOI (link) - ^ Ikegaya, Shunsuke; Iga, Yurika; Mikawa, Sumiko; Zhou, Li; Abe, Manabu; Sakimura, Kenji; Sato, Kohji; Yamagishi, Satoru (2020). "Decreased Proliferation in the Neurogenic Niche, Disorganized Neuroblast Migration, and Increased Oligodendrogenesis in Adult Netrin-5-Deficient Mice". Frontiers in Neuroscience. 14: 570974. doi:10.3389/fnins.2020.570974. ISSN 1662-4548. PMC 7726356. PMID 33324143.
{{cite journal}}: CS1 maint: unflagged free DOI (link) - ^ a b Gaudet, Pascale; Livstone, Michael S.; Lewis, Suzanna E.; Thomas, Paul D. (2011-09). "Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium". Briefings in Bioinformatics. 12 (5): 449–462. doi:10.1093/bib/bbr042. ISSN 1477-4054. PMC 3178059. PMID 21873635.
{{cite journal}}: Check date values in:|date=(help) - ^ Wightman, Douglas P.; Jansen, Iris E.; Savage, Jeanne E.; Shadrin, Alexey A.; Bahrami, Shahram; Holland, Dominic; Rongve, Arvid; Børte, Sigrid; Winsvold, Bendik S.; Drange, Ole Kristian; Martinsen, Amy E. (2021-09). "A genome-wide association study with 1,126,563 individuals identifies new risk loci for Alzheimer's disease". Nature Genetics. 53 (9): 1276–1282. doi:10.1038/s41588-021-00921-z. ISSN 1546-1718.
{{cite journal}}: Check date values in:|date=(help) - ^ Bruikman, Caroline Suzanne; Zhang, Huayu; Kemper, Anneli Maite; van Gils, Janine Maria (2019-02-24). "Netrin Family: Role for Protein Isoforms in Cancer". Journal of Nucleic Acids. 2019: e3947123. doi:10.1155/2019/3947123. ISSN 2090-0201.
{{cite journal}}: CS1 maint: unflagged free DOI (link)