Ras-interacting protein 1: Difference between revisions
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←Created page with 'Ras-interacting protein 1 (RASIP1), also known as RAIN, is a protein that in humans is encoded by the ''RASIP1'' gene.<ref>{{Cite web|title=RASIP1 - Ras-interacting protein 1 - Homo sapiens (Human) - RASIP1 gene & protein|url=https://www.uniprot.org/uniprot/Q5U651|access-date=2021-12-11|website=www.uniprot.org|language=en}}</ref> == Function == RASIP1: * It's required for the proper formation of vascular structures that develop via both vasculo...' |
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Revision as of 10:19, 11 December 2021
Ras-interacting protein 1 (RASIP1), also known as RAIN, is a protein that in humans is encoded by the RASIP1 gene.[1]
Function
RASIP1:
- It's required for the proper formation of vascular structures that develop via both vasculogenesis and angiogenesis. [2]
- Acts as a critical and vascular-specific regulator of GTPase signaling, cell architecture, and adhesion, which is essential for endothelial cell morphogenesis and blood vessel tubulogenesis. [3][4][5]
- Regulates the activity of Rho GTPases in part by recruiting ARHGAP29 and suppressing RhoA signaling and dampening ROCK and MYH9 activities in endothelial cells.[6][7]
Clinical significance
A recent genome-wide association study (GWAS) has found that genetic variations in HAVCR2 are associated with late-onset sporadic Alzheimer’s disease (LOAD). However, it's unknown how netrin-5 mutation contributes to disease.[8]
References
- ^ "RASIP1 - Ras-interacting protein 1 - Homo sapiens (Human) - RASIP1 gene & protein". www.uniprot.org. Retrieved 2021-12-11.
- ^ Wilson, Christopher W.; Ye, Weilan (2014). "Regulation of vascular endothelial junction stability and remodeling through Rap1-Rasip1 signaling". Cell Adhesion & Migration. 8 (2): 76–83. doi:10.4161/cam.28115. ISSN 1933-6926. PMC 4049864. PMID 24622510.
- ^ Koo, Yeon; Barry, David M.; Xu, Ke; Tanigaki, Keiji; Davis, George E.; Mineo, Chieko; Cleaver, Ondine (2016-04). "Rasip1 is essential to blood vessel stability and angiogenic blood vessel growth". Angiogenesis. 19 (2): 173–190. doi:10.1007/s10456-016-9498-5. ISSN 1573-7209. PMC 4808411. PMID 26897025.
{{cite journal}}: Check date values in:|date=(help) - ^ Liu, Xiaolei; Gu, Xiaowu; Ma, Wanshu; Oxendine, Michael; Gil, Hyea Jin; Davis, George E.; Cleaver, Ondine; Oliver, Guillermo (2018-08-20). "Rasip1 controls lymphatic vessel lumen maintenance by regulating endothelial cell junctions". Development (Cambridge, England). 145 (17): dev165092. doi:10.1242/dev.165092. ISSN 1477-9129. PMC 6141773. PMID 30042182.
- ^ Xu, Ke; Chong, Diana C.; Rankin, Scott A.; Zorn, Aaron M.; Cleaver, Ondine (2009-05-15). "Rasip1 is required for endothelial cell motility, angiogenesis and vessel formation". Developmental Biology. 329 (2): 269–279. doi:10.1016/j.ydbio.2009.02.033. ISSN 1095-564X. PMC 2683470. PMID 19272373.
- ^ Barry, David M.; Koo, Yeon; Norden, Pieter R.; Wylie, Lyndsay A.; Xu, Ke; Wichaidit, Chonlarat; Azizoglu, D. Berfin; Zheng, Yi; Cobb, Melanie H.; Davis, George E.; Cleaver, Ondine (2016-09-16). "Rasip1-Mediated Rho GTPase Signaling Regulates Blood Vessel Tubulogenesis via Nonmuscle Myosin II". Circulation Research. 119 (7): 810–826. doi:10.1161/CIRCRESAHA.116.309094. ISSN 1524-4571. PMC 5026621. PMID 27486147.
- ^ Mitin, Natalia Y.; Ramocki, Melissa B.; Zullo, Alfred J.; Der, Channing J.; Konieczny, Stephen F.; Taparowsky, Elizabeth J. (2004-05-21). "Identification and Characterization of Rain, a Novel Ras-interacting Protein with a Unique Subcellular Localization *". Journal of Biological Chemistry. 279 (21): 22353–22361. doi:10.1074/jbc.M312867200. ISSN 0021-9258. PMID 15031288.
{{cite journal}}: CS1 maint: unflagged free DOI (link) - ^ Wightman, Douglas P.; Jansen, Iris E.; Savage, Jeanne E.; Shadrin, Alexey A.; Bahrami, Shahram; Holland, Dominic; Rongve, Arvid; Børte, Sigrid; Winsvold, Bendik S.; Drange, Ole Kristian; Martinsen, Amy E. (2021-09). "A genome-wide association study with 1,126,563 individuals identifies new risk loci for Alzheimer's disease". Nature Genetics. 53 (9): 1276–1282. doi:10.1038/s41588-021-00921-z. ISSN 1546-1718.
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