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==Scientific contribution==
==Scientific contribution==
Hierlemann’s research initially was mostly in the area of [[chemical sensor]]s and [[microsensor]]s.<ref name="A1">{{cite journal | last=Hagleitner | first=C. | last2=Hierlemann | first2=A. | last3=Lange | first3=D. | last4=Kummer | first4=A. | last5=Kerness | first5=N. | last6=Brand | first6=O. | last7=Baltes | first7=H. | title=Smart single-chip gas sensor microsystem | journal=Nature | publisher=Springer Science and Business Media LLC | volume=414 | issue=6861 | year=2001 | issn=0028-0836 | doi=10.1038/35104535 | pages=293–296}}</ref><ref name ="A2">{{cite journal | last=Hierlemann | first=Andreas | last2=Gutierrez-Osuna | first2=Ricardo | title=Higher-Order Chemical Sensing | journal=Chemical Reviews | publisher=American Chemical Society (ACS) | volume=108 | issue=2 | date=17 January 2008 | issn=0009-2665 | doi=10.1021/cr068116m | pages=563–613}}</ref> In particular, he worked on the detection of organic [[volatility (chemistry)|volatiles]] and the discrimination of [[enantiomer]]s in the gas phase.<ref name="A3">{{cite journal | last=Bodenhöfer | first=K. | last2=Hierlemann | first2=A. | last3=Seemann | first3=J. | last4=Gauglitz | first4=G. | last5=Koppenhoefer | first5=B. | last6=Gpel | first6=W. | title=Chiral discrimination using piezoelectric and optical gas sensors | journal=Nature | publisher=Springer Science and Business Media LLC | volume=387 | issue=6633 | year=1997 | issn=0028-0836 | doi=10.1038/42426 | pages=577–580}}</ref><ref name="A4">{{cite journal | last=Kurzawski | first=Petra | last2=Bogdanski | first2=Anja | last3=Schurig | first3=Volker | last4=Wimmer | first4=Reinhard | last5=Hierlemann | first5=Andreas | title=Opposite Signs of Capacitive Microsensor Signals upon Exposure to the Enantiomers of Methyl Propionate Compounds | journal=Angewandte Chemie International Edition | publisher=Wiley | volume=47 | issue=5 | date=18 January 2008 | issn=1433-7851 | doi=10.1002/anie.200704346 | pages=913–916}}</ref> He then adopted microtechnology and, specifically, CMOS-based microelectronics to devise complex microsensor systems.<ref name="A1" /><ref name="A5">A. Hierlemann (2005). Integrated Chemical Microsensor Systems in CMOS Technology, Springer Verlag,p. 229, {{ISBN|3-540-23782-8}}.</ref><ref name="A6">S. Hafizovic, D. Barrettino, T. Volden, J. Sedivy, K.-U. Kirstein, O. Brand, A. Hierlemann (2004). Single-chip mechatronic microsystem for surface imaging and force response studies. PNAS, Vol. 101, No. 49, pp. 17011-17015.</ref> The current interdisciplinary research is rooted in engineering and physics and targeted at questions in biology and medicine. It includes the development of CMOS-based integrated chemical and biomicrosystems,<ref name="A1" /><ref name="A5" /><ref name="A6" /> as well as [[bioelectronics]] and high-density microelectrode arrays.<ref name="A7">U. Frey, U. Egert, F. Heer, S. Hafizovic, and A. Hierlemann (2009). Microelectronic System for High-Resolution Mapping of Extracellular Electric Fields Applied to Brain Slices. Biosensors and Bioelectronics, 24, pp. 2191–2198.</ref><ref name="A8">A. Hierlemann, U. Frey, S. Hafizovic, F. Heer (2011). Growing Cells atop Microelectronic Chips: Interfacing Electrogenic Cells in Vitro with CMOS-based Microelectrode Arrays. Proceedings of the IEEE, Vol. 99, No. 2, pp. 252–284.</ref><ref name="A9">D. J. Bakkum, U. Frey, M. Radivojevic, T. L. Russell, J. Müller, M. Fiscella, H. Takahashi, A. Hierlemann (2013). Tracking axonal action potential propagation on a high-density microelectrode array across hundreds of sites. Nature Communications 2013, 4:2181.</ref> The high-density microelectrode arrays are used for fundamental research in information processing and signaling characteristics of neurons or brain cells.<ref name="A7" /><ref name="A8" /><ref name="A9" /> Moreover, the research group is engaged in the development of [[microfluidics]] for investigating the characteristics of single cells and microtissues.
Hierlemann’s research initially was mostly in the area of [[chemical sensor]]s and [[microsensor]]s.<ref name="A1">{{cite journal | last=Hagleitner | first=C. | last2=Hierlemann | first2=A. | last3=Lange | first3=D. | last4=Kummer | first4=A. | last5=Kerness | first5=N. | last6=Brand | first6=O. | last7=Baltes | first7=H. | title=Smart single-chip gas sensor microsystem | journal=Nature | publisher=Springer Science and Business Media LLC | volume=414 | issue=6861 | year=2001 | issn=0028-0836 | doi=10.1038/35104535 | pages=293–296}}</ref><ref name ="A2">{{cite journal | last=Hierlemann | first=Andreas | last2=Gutierrez-Osuna | first2=Ricardo | title=Higher-Order Chemical Sensing | journal=Chemical Reviews | publisher=American Chemical Society (ACS) | volume=108 | issue=2 | date=17 January 2008 | issn=0009-2665 | doi=10.1021/cr068116m | pages=563–613}}</ref> In particular, he worked on the detection of organic [[volatility (chemistry)|volatiles]] and the discrimination of [[enantiomer]]s in the gas phase.<ref name="A3">{{cite journal | last=Bodenhöfer | first=K. | last2=Hierlemann | first2=A. | last3=Seemann | first3=J. | last4=Gauglitz | first4=G. | last5=Koppenhoefer | first5=B. | last6=Gpel | first6=W. | title=Chiral discrimination using piezoelectric and optical gas sensors | journal=Nature | publisher=Springer Science and Business Media LLC | volume=387 | issue=6633 | year=1997 | issn=0028-0836 | doi=10.1038/42426 | pages=577–580}}</ref><ref name="A4">{{cite journal | last=Kurzawski | first=Petra | last2=Bogdanski | first2=Anja | last3=Schurig | first3=Volker | last4=Wimmer | first4=Reinhard | last5=Hierlemann | first5=Andreas | title=Opposite Signs of Capacitive Microsensor Signals upon Exposure to the Enantiomers of Methyl Propionate Compounds | journal=Angewandte Chemie International Edition | publisher=Wiley | volume=47 | issue=5 | date=18 January 2008 | issn=1433-7851 | doi=10.1002/anie.200704346 | pages=913–916}}</ref> He then adopted microtechnology and, specifically, CMOS-based microelectronics to devise complex microsensor systems.<ref name="A1" /><ref name="A5">{{cite book | last=Hierlemann | first=A | title=Integrated chemical microsensor systems in CMOS technology | publisher=Springer | publication-place=Berlin New York | year=2005 | isbn=978-3-540-27372-1 | oclc=262677851 | page=}}</ref><ref name="A6">{{cite journal | last=Hafizovic | first=S. | last2=Barrettino | first2=D. | last3=Volden | first3=T. | last4=Sedivy | first4=J. | last5=Kirstein | first5=K.-U. | last6=Brand | first6=O. | last7=Hierlemann | first7=A. | title=Single-chip mechatronic microsystem for surface imaging and force response studies | journal=Proceedings of the National Academy of Sciences | publisher=Proceedings of the National Academy of Sciences | volume=101 | issue=49 | date=29 November 2004 | issn=0027-8424 | doi=10.1073/pnas.0405725101 | pages=17011–17015}}</ref> The current interdisciplinary research is rooted in engineering and physics and targeted at questions in biology and medicine. It includes the development of CMOS-based integrated chemical and biomicrosystems,<ref name="A1" /><ref name="A5" /><ref name="A6" /> as well as [[bioelectronics]] and high-density microelectrode arrays.<ref name="A7">{{cite journal | last=Frey | first=U. | last2=Egert | first2=U. | last3=Heer | first3=F. | last4=Hafizovic | first4=S. | last5=Hierlemann | first5=A. | title=Microelectronic system for high-resolution mapping of extracellular electric fields applied to brain slices | journal=Biosensors and Bioelectronics | publisher=Elsevier BV | volume=24 | issue=7 | year=2009 | issn=0956-5663 | doi=10.1016/j.bios.2008.11.028 | pages=2191–2198}}</ref><ref name="A8">{{cite journal | last=Hierlemann | first=A | last2=Frey | first2=U | last3=Hafizovic | first3=S | last4=Heer | first4=F | title=Growing Cells Atop Microelectronic Chips: Interfacing Electrogenic Cells In Vitro With CMOS-Based Microelectrode Arrays | journal=Proceedings of the IEEE | publisher=Institute of Electrical and Electronics Engineers (IEEE) | volume=99 | issue=2 | year=2011 | issn=0018-9219 | doi=10.1109/jproc.2010.2066532 | pages=252–284}}</ref><ref name="A9">{{cite journal | last=Bakkum | first=Douglas J. | last2=Frey | first2=Urs | last3=Radivojevic | first3=Milos | last4=Russell | first4=Thomas L. | last5=Müller | first5=Jan | last6=Fiscella | first6=Michele | last7=Takahashi | first7=Hirokazu | last8=Hierlemann | first8=Andreas | title=Tracking axonal action potential propagation on a high-density microelectrode array across hundreds of sites | journal=Nature Communications | publisher=Springer Science and Business Media LLC | volume=4 | issue=1 | date=19 July 2013 | issn=2041-1723 | doi=10.1038/ncomms3181 | page=}}</ref> The high-density microelectrode arrays are used for fundamental research in information processing and signaling characteristics of neurons or brain cells.<ref name="A7" /><ref name="A8" /><ref name="A9" /> Moreover, the research group is engaged in the development of [[microfluidics]] for investigating the characteristics of single cells and microtissues.


Applications of Hierlemann's and his group's technologies are in the fields of [[systems biology]], [[drug test]]ing, [[personalized medicine]], and [[neuroscience]].
Applications of Hierlemann's and his group's technologies are in the fields of [[systems biology]], [[drug test]]ing, [[personalized medicine]], and [[neuroscience]].

Revision as of 08:33, 19 December 2021

Andreas Hierlemann
Andreas Hierlemann, 2016
Born
17 August 1964 (1964-08-17) (age 59)
NationalityGerman
Known forDevelopment of CMOS chemical and biomicrosensors, CMOS high-density microelectrode arrays
Scientific career
FieldsBiosystems engineering
InstitutionsETH Zurich

Andreas Hierlemann (17 August 1964) is a German chemist and professor of Biosystems Engineering at ETH Zurich. He is known for his work in the field of CMOS-based chemical and biomicrosensors and high-density microelectrode arrays.

Life

From 1985–91 Hierlemann studied chemistry at the University of Tübingen, Germany. He received a PhD from the University of Tübingen in 1996 for his work on Mass-sensitive detection of organic volatiles using modified polysiloxanes. 1997–98 he held postdoctoral positions at Texas A&M University in College Station, Texas, USA, and at Sandia National Laboratories in Albuquerque, New Mexico, USA. From 1999 to 2004 he was research team leader at the Physical Electronics Laboratory in the Department of Physics of ETH Zürich, Switzerland, becoming associate professor for microsensors in 2004. In 2008 he was named full professor of Biosystems Engineering, Department of Biosystems Science and Engineering of ETH Zurich in Basel, Switzerland.

Scientific contribution

Hierlemann’s research initially was mostly in the area of chemical sensors and microsensors.[1][2] In particular, he worked on the detection of organic volatiles and the discrimination of enantiomers in the gas phase.[3][4] He then adopted microtechnology and, specifically, CMOS-based microelectronics to devise complex microsensor systems.[1][5][6] The current interdisciplinary research is rooted in engineering and physics and targeted at questions in biology and medicine. It includes the development of CMOS-based integrated chemical and biomicrosystems,[1][5][6] as well as bioelectronics and high-density microelectrode arrays.[7][8][9] The high-density microelectrode arrays are used for fundamental research in information processing and signaling characteristics of neurons or brain cells.[7][8][9] Moreover, the research group is engaged in the development of microfluidics for investigating the characteristics of single cells and microtissues.

Applications of Hierlemann's and his group's technologies are in the fields of systems biology, drug testing, personalized medicine, and neuroscience.

Awards

Publication list

References

  1. ^ a b c Hagleitner, C.; Hierlemann, A.; Lange, D.; Kummer, A.; Kerness, N.; Brand, O.; Baltes, H. (2001). "Smart single-chip gas sensor microsystem". Nature. 414 (6861). Springer Science and Business Media LLC: 293–296. doi:10.1038/35104535. ISSN 0028-0836.
  2. ^ Hierlemann, Andreas; Gutierrez-Osuna, Ricardo (17 January 2008). "Higher-Order Chemical Sensing". Chemical Reviews. 108 (2). American Chemical Society (ACS): 563–613. doi:10.1021/cr068116m. ISSN 0009-2665.
  3. ^ Bodenhöfer, K.; Hierlemann, A.; Seemann, J.; Gauglitz, G.; Koppenhoefer, B.; Gpel, W. (1997). "Chiral discrimination using piezoelectric and optical gas sensors". Nature. 387 (6633). Springer Science and Business Media LLC: 577–580. doi:10.1038/42426. ISSN 0028-0836.
  4. ^ Kurzawski, Petra; Bogdanski, Anja; Schurig, Volker; Wimmer, Reinhard; Hierlemann, Andreas (18 January 2008). "Opposite Signs of Capacitive Microsensor Signals upon Exposure to the Enantiomers of Methyl Propionate Compounds". Angewandte Chemie International Edition. 47 (5). Wiley: 913–916. doi:10.1002/anie.200704346. ISSN 1433-7851.
  5. ^ a b Hierlemann, A (2005). Integrated chemical microsensor systems in CMOS technology. Berlin New York: Springer. ISBN 978-3-540-27372-1. OCLC 262677851.
  6. ^ a b Hafizovic, S.; Barrettino, D.; Volden, T.; Sedivy, J.; Kirstein, K.-U.; Brand, O.; Hierlemann, A. (29 November 2004). "Single-chip mechatronic microsystem for surface imaging and force response studies". Proceedings of the National Academy of Sciences. 101 (49). Proceedings of the National Academy of Sciences: 17011–17015. doi:10.1073/pnas.0405725101. ISSN 0027-8424.
  7. ^ a b Frey, U.; Egert, U.; Heer, F.; Hafizovic, S.; Hierlemann, A. (2009). "Microelectronic system for high-resolution mapping of extracellular electric fields applied to brain slices". Biosensors and Bioelectronics. 24 (7). Elsevier BV: 2191–2198. doi:10.1016/j.bios.2008.11.028. ISSN 0956-5663.
  8. ^ a b Hierlemann, A; Frey, U; Hafizovic, S; Heer, F (2011). "Growing Cells Atop Microelectronic Chips: Interfacing Electrogenic Cells In Vitro With CMOS-Based Microelectrode Arrays". Proceedings of the IEEE. 99 (2). Institute of Electrical and Electronics Engineers (IEEE): 252–284. doi:10.1109/jproc.2010.2066532. ISSN 0018-9219.
  9. ^ a b Bakkum, Douglas J.; Frey, Urs; Radivojevic, Milos; Russell, Thomas L.; Müller, Jan; Fiscella, Michele; Takahashi, Hirokazu; Hierlemann, Andreas (19 July 2013). "Tracking axonal action potential propagation on a high-density microelectrode array across hundreds of sites". Nature Communications. 4 (1). Springer Science and Business Media LLC. doi:10.1038/ncomms3181. ISSN 2041-1723.

External links

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