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←Created page with '{{Chembox <!-- Images --> | ImageFile = | ImageSize = | ImageAlt = <!-- Names --> | IUPACName = 10-formyl-9-hydroxy-3-methoxy-4,7-dimethyl-6-oxobenzo[b][1,4]benzodioxepine-1-carboxylic acid<ref name=Psoromic-acid>{{cite journal |title=Psoromic acid |journal=pubchem.ncbi.nlm.nih.gov |url=https://pubchem.ncbi.nlm.nih.gov/compound/Psoromic-acid |language=en}}</ref> | OtherNames = <!-- Sections --> | Section1 = {{Chembox Ident...'
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Revision as of 09:02, 27 February 2022

Psoromic acid
Names
IUPAC name
10-formyl-9-hydroxy-3-methoxy-4,7-dimethyl-6-oxobenzo[b][1,4]benzodioxepine-1-carboxylic acid[1]
Identifiers
3D model (JSmol)
  • CC1=C(OC)C=C(C(O)=O)C(OC2=C3C(C)=CC(O)=C2C=O)=C1OC3=O[2]
Properties
C18H14O8
Molar mass 358.302 g·mol−1
Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa).

Psoromic acid is a β-Orcinol depsidone with the molecular formula C18H14O8.[3][1][4] Psoromic acid inhibits herpes simplex viruses from type 1 and type 2.[4] Futermore it inhibits the RabGGTase.[5] Psoromic acid occurs in antarctic lichens.[4][3]

References

  1. ^ a b "Psoromic acid". pubchem.ncbi.nlm.nih.gov.
  2. ^ "Psoromic Acid (CAS 7299-11-8)". www.caymanchem.com.
  3. ^ a b Sukumaran, Swapna Thacheril; Sugathan, Shiburaj; Abdulhameed, Sabu (28 November 2020). Plant Metabolites: Methods, Applications and Prospects. Springer Nature. p. 278. ISBN 978-981-15-5136-9.
  4. ^ a b c Hassan, Sherif T. S.; Šudomová, Miroslava; Berchová-Bímová, Kateřina; Šmejkal, Karel; Echeverría, Javier (11 August 2019). "Psoromic Acid, a Lichen-Derived Molecule, Inhibits the Replication of HSV-1 and HSV-2, and Inactivates HSV-1 DNA Polymerase: Shedding Light on Antiherpetic Properties". Molecules. 24 (16): 2912. doi:10.3390/molecules24162912.{{cite journal}}: CS1 maint: unflagged free DOI (link)
  5. ^ Deraeve, Céline; Guo, Zhong; Bon, Robin S.; Blankenfeldt, Wulf; DiLucrezia, Raffaella; Wolf, Alexander; Menninger, Sascha; Stigter, E. Anouk; Wetzel, Stefan; Choidas, Axel; Alexandrov, Kirill; Waldmann, Herbert; Goody, Roger S.; Wu, Yao-Wen (2 May 2012). "Psoromic Acid is a Selective and Covalent Rab-Prenylation Inhibitor Targeting Autoinhibited RabGGTase". Journal of the American Chemical Society. 134 (17): 7384–7391. doi:10.1021/ja211305j.

Further reading

  • Deraeve, Céline; Guo, Zhong; Bon, Robin S.; Blankenfeldt, Wulf; DiLucrezia, Raffaella; Wolf, Alexander; Menninger, Sascha; Stigter, E. Anouk; Wetzel, Stefan; Choidas, Axel; Alexandrov, Kirill; Waldmann, Herbert; Goody, Roger S.; Wu, Yao-Wen (2 May 2012). "Psoromic Acid is a Selective and Covalent Rab-Prenylation Inhibitor Targeting Autoinhibited RabGGTase". Journal of the American Chemical Society. 134 (17): 7384–7391. doi:10.1021/ja211305j.
  • Der Stoffwechsel Sekundärer Pflanzenstoffe / The Metabolism of Secondary Plant Products. Springer Science & Business Media. 11 November 2013. p. 592. ISBN 978-3-662-26784-4.
  • Year-book of Pharmacy. J. & A. Churchill. 1883. p. 246.
  • Issues in Chemistry and General Chemical Research: 2013 Edition. ScholarlyEditions. 1 May 2013. p. 323. ISBN 978-1-4901-0631-1.
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