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Conventional treatment of modic changes
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===Treatment===
==Treatment==


==Exercise and surgery alone are ineffective treatments for patients with Modic changes==
===Exercise and surgery alone are ineffective treatments for patients with Modic changes===

The most commonly recommended treatment for long-lasting pain in the lower back are exercises and fitness training usually under the supervision of a qualified clinician. This treatment does help the vast majority of back pain patients but does not have a pain-relieving effect on Modic changes or pain from Modic changes.<ref>{{cite journal |last1=Jensen |first1=Rikke K |last2=Leboeuf-Yde |first2=Charlotte |last3=Wedderkopp |first3=Niels |last4=Sorensen |first4=Joan S |last5=Manniche |first5=Claus |title=Rest versus exercise as treatment for patients with low back pain and Modic changes. a randomized controlled clinical trial |journal=BMC Medicine |date=December 2012 |volume=10 |issue=1 |pages=22 |doi=10.1186/1741-7015-10-22}}</ref>

Modic changes are also an independent predictive marker for poor clinical outcomes<ref>{{cite journal |last1=Jensen |first1=Rikke K |last2=Leboeuf-Yde |first2=Charlotte |last3=Wedderkopp |first3=Niels |last4=Sorensen |first4=Joan S |last5=Manniche |first5=Claus |title=Rest versus exercise as treatment for patients with low back pain and Modic changes. a randomized controlled clinical trial |journal=BMC Medicine |date=December 2012 |volume=10 |issue=1 |pages=22 |doi=10.1186/1741-7015-10-22}}</ref><ref>{{cite journal |last1=Saukkonen |first1=Jesperi |last2=Määttä |first2=Juhani |last3=Oura |first3=Petteri |last4=Kyllönen |first4=Eero |last5=Tervonen |first5=Osmo |last6=Niinimäki |first6=Jaakko |last7=Auvinen |first7=Juha |last8=Karppinen |first8=Jaro |title=Association Between Modic Changes and Low Back Pain in Middle Age: A Northern Finland Birth Cohort Study |journal=Spine |date=1 October 2020 |volume=45 |issue=19 |pages=1360–1367 |doi=10.1097/BRS.0000000000003529}}</ref> <ref>{{cite journal |last1=Määttä |first1=Juhani H. |last2=Wadge |first2=Sam |last3=MacGregor |first3=Alex |last4=Karppinen |first4=Jaro |last5=Williams |first5=Frances M.K. |title=ISSLS Prize Winner: Vertebral Endplate (Modic) Change is an Independent Risk Factor for Episodes of Severe and Disabling Low Back Pain |journal=Spine |date=August 2015 |volume=40 |issue=15 |pages=1187–1193 |doi=10.1097/BRS.0000000000000937}}</ref> <ref>{{cite journal |last1=Munir |first1=Sabrina |last2=Freidin |first2=Maxim B. |last3=Rade |first3=Marinko |last4=Määttä |first4=Juhani |last5=Livshits |first5=Gregory |last6=Williams |first6=Frances M.K. |title=Endplate Defect Is Heritable, Associated With Low Back Pain and Triggers Intervertebral Disc Degeneration: A Longitudinal Study From TwinsUK |journal=Spine |date=1 November 2018 |volume=43 |issue=21 |pages=1496–1501 |doi=10.1097/BRS.0000000000002721}}</ref> <ref>{{cite journal |last1=Saukkonen |first1=Jesperi |last2=Määttä |first2=Juhani |last3=Oura |first3=Petteri |last4=Kyllönen |first4=Eero |last5=Tervonen |first5=Osmo |last6=Niinimäki |first6=Jaakko |last7=Auvinen |first7=Juha |last8=Karppinen |first8=Jaro |title=Association Between Modic Changes and Low Back Pain in Middle Age: A Northern Finland Birth Cohort Study |journal=Spine |date=1 October 2020 |volume=45 |issue=19 |pages=1360–1367 |doi=10.1097/BRS.0000000000003529}}</ref>, meaning that conventional treatments such as strength training, manipulations, physiotherapy, acupuncture, and surgery do not reduce the pain of individuals with Modic changes.


It is difficult to treat patients with Modic changes. Treatment that normally cures or help patients with normal back pain does not have effect on Modic changes or pain from Modic changes.


The recommended treatment for long lasting pain in the lower back is exercises, normally aided by the instruction of a qualified clinician. This is often followed by muscle strengthening and [[fitness training]]. This treatment does help the vast majority of normal back pain patients. But studies{{which|date=July 2011}} have shown that patients with Modic changes showed much higher pain score than patients with normal back pain, and most importantly that their pain increased with training. Other recent studies cited state no clinical difference between load reduction and rest or doing physio in relation to management or improvement of the condition.
The recommended treatment for long lasting pain in the lower back is exercises, normally aided by the instruction of a qualified clinician. This is often followed by muscle strengthening and [[fitness training]]. This treatment does help the vast majority of normal back pain patients. But studies{{which|date=July 2011}} have shown that patients with Modic changes showed much higher pain score than patients with normal back pain, and most importantly that their pain increased with training. Other recent studies cited state no clinical difference between load reduction and rest or doing physio in relation to management or improvement of the condition.

Revision as of 09:16, 11 June 2022

Modic changes are pathological changes in the bones of the spine, the vertebrae. These changes are situated in both the body of the vertebrae and in the end plate of the neighboring disc. Clinically, Modic Changes are often associated with constant lower back pain during the day, with peak pain occurring during the night and in the morning, coupled with back stiffness.[1][2]

Modic changes have been observed in approximately 6 % of the general adult population regardless of ethnicity.[3][4][5][6] Modic changes are rare in children and young adults. From the age of 25 to 40 years, there is a steep increase in their prevalence, which levels out about 40 years of age and is stable until 80+ years.[7] Modic changes are estimated to affect approximately 349 million of the adult population worldwide.[July 2021 est.][8]

Modic changes is a descriptive term used by radiologists in MRI evaluations. Conventional treatment including physiotherapy, chiropractic, acupuncture, and exercise for back pain, are ineffective in treating Modic changes. Conversely, long term antibiotic treatment has been shown to be an effective treatment if done effectively.

Signs and Symptomps

Several studies have shown a relationship between Modic changes in the spinal vertebrae and pain in the lower back.

Long term chronic pain

The last decade of studies on Modic changes have shown that Modic changes are associated with many treatment-resistant pain episodes and may result in patients entering a state of chronic low back pain. On average, individuals with Modic changes have had chronic pain for longer than individuals suffering from non-Modic changes back pain.[9][10]

Nightly Pain

Peak pain tends to occur late at night and morning and often late-night pain often results in poor and interrupted sleep.[11][12]

Morning pain and stiffness

Many individuals suffering from Modic changes, tend to have a high degree of morning stiffness in the back. The duration of the stiffness in the morning also tends to be longer compared to individuals with no Modic changes.[13][14]

Pain with lumbar hyperextension

Individuals with Modic changes experience exacerbation of pain when performing a hyperextension of the back.[15][16] A hyperextension of the back is the equivalent of performing an excessive backward bending of the back beyond its natural position.

Causes and Prevalence

Modic changes are a non-specific pathoanatomical marker observed on an MRI scan. For example, high blood pressure or high body temperature can be markers of several diseases. In 2008 the first hypothesis suggesting three possible pathogenetic reasons for Modic changes was published, a bacterial, a mechanical, and a rheumatological cause.[17]

Bacteria as a cause

The bacterial cause is where the development of Modic change is due to an infection in the adjacent disc. A tear in the outer fibers of a disc may well initiate this infection. A disc herniation will result in a new local capillarization around the extruded material as the body attempts to remove the extruded material and inflammation with macrophages which are present in abundance.[18][19][20][21][22] The mucous membrane of the gums is slightly damaged during ordinary tooth brushing, and anaerobic bacteria Propionibacterium Acne’s type 2 from the mouth enters the bloodstream.[23][24][25]

The anaerobic bacteria can enter the disc through the breach, causing a low virulent and slowly developing infection. Since the disc is an avascular structure, it is an ideal environment for the growth of anaerobic bacteria. Propionibacterium acnes bacteria secrete propionic acid, which can dissolve fatty bone marrow and bone. Therefore, it was hypothesized that diffusion of propionic acid from the disc into the vertebrae results in bone oedema, i.e. Modic changes.

The first study by Stirling and Lambert found Propionibacterium acnes in the extruded disc material in patients undergoing surgery[26] inspired the bacterial theory[27]. The discovery has led to many studies trying to identify bacteria in the disc material. The methods used in the studies to determine the presence of bacteria vary significantly from very primitive methods such as simple culturing to highly sophisticated methods, where independent research groups utilizing staining techniques with fluorescence in situ hybridization were able to visualize bacteria from an ongoing infection as well as associated inflammatory cells. These studies were carried out in real time and therefore demonstrated an ongoing bacterial infection.[28][29] The results of these studies have been reproduced in several systematic reviews, concluding that 30-34 % of patients with a disc herniation have bacteria in the extruded disc material. [30] [31] [32].

Mechanical

Mechanical Modic changes might initially reflect bleeding, oedema, and vascularization following trauma or oedema associated with the repair process after micro-fractures within the endplate and the vertebral bone. Another possibility is that the toxic nucleus tissue (from the center of the discs) invades the endplate and vertebral bone through fractures in the endplates and causes an inflammatory response.[33] It may be nucleus material entering the vertebrae, but Crock et al. also suggested that after a disc is damaged, irritating substances are produced, draining into the vertebral body, and causing an autoimmune reaction.[34] This mechanical theory is supported by the fact that histological findings of the Modic Changes demonstrate disruption of the endplates with evidence of chronic inflammation. This in turn suggests that this erosion weakens the bone matrix, giving rise to stress fractures and consequent oedema, the universal reaction of bone under stress seen in fractures wherever they occur and always associated with pain.

Prevalence

Modic changes have been observed in approximately 6 % of the general adult population regardless of ethnicity.[35][36][37][38] Modic changes are rare in children and young adults. From the age of 25 to 40 years, there is a steep increase in their prevalence, which levels out about 40 years of age and is stable until 80+ years.[39] Modic changes are estimated to affect approximately 349 million of the adult population worldwide.[July 2021 est.][40]

Modic changes do not disappear

The natural development of Modic changes was observed in an extensive study of almost 800 English twins. These twins had an initial MRI diagnosing them with Modic changes and another MRI 10 years later. No treatment was given, thus only observing the development of Modic changes. The study showed that only 3.5 % of the people who had Modic changes initially demonstrated that they had disappeared after ten years. Unfortunately, most of the Modic changes do not resolve spontaneously.[41]

Diagnosing Modic changes

Modic changes are observed on MRI (magnetic resonance imaging) scans. Bone oedema in other bones is not categorized into different types, but Dr. Michael Modic was the first to classify, describe and define Modic changes into three types. The different types were first described and defined in 1988.[42]

Normal bone contains internal scaffolding, called trabeculae. Red bone marrow, which produces blood cells, is located in the hollows between the trabeculae.

  • Modic changes Type 1 reflects oedema adjacent to the disc, fissured endplates, microfractures of the trabeculae, granular tissue, high levels of immunoreactive nerve fibers, and TNF alpha cells (pro-inflammatory)[43][44]
  • Modic changes Type 2 contains high levels of fat associated with degeneration of the bone marrow, microfractures of the trabeculae, disruption of the endplates, and immunoreactive nerve fibers and TNF alpha cells.[45] [46][47][48] A mix of Type 1 and Type 2 have frequently been observed in the exact Modic change.[49][50]
  • Modic Change type 3 is rare and suggests a more stable sclerotic phase. [51][52]

The proof of an ongoing pathologic process in a Modic change has been documented by SPECT analysis [Isotope scanning using single positron emission computerized tomography], combined with high-resolution CT imaging. This method has shown high metabolic activity in 96.1% of endplates with Modic change type I and 56% with Modic change type 2.[53]

Modic changes have been observed in dogs.[54]


Treatment

Exercise and surgery alone are ineffective treatments for patients with Modic changes

The most commonly recommended treatment for long-lasting pain in the lower back are exercises and fitness training usually under the supervision of a qualified clinician. This treatment does help the vast majority of back pain patients but does not have a pain-relieving effect on Modic changes or pain from Modic changes.[55]

Modic changes are also an independent predictive marker for poor clinical outcomes[56][57] [58] [59] [60], meaning that conventional treatments such as strength training, manipulations, physiotherapy, acupuncture, and surgery do not reduce the pain of individuals with Modic changes.


The recommended treatment for long lasting pain in the lower back is exercises, normally aided by the instruction of a qualified clinician. This is often followed by muscle strengthening and fitness training. This treatment does help the vast majority of normal back pain patients. But studies[which?] have shown that patients with Modic changes showed much higher pain score than patients with normal back pain, and most importantly that their pain increased with training. Other recent studies cited state no clinical difference between load reduction and rest or doing physio in relation to management or improvement of the condition. [61]

Research

The following section is controversial [62] with concerns over methodology and also potential conflicts of interest, in that some of the researchers are associated with a company which certifies clinicians to diagnose the condition for £200. It is true that a study has been published, and results are interesting. However, spinal clinicians and researchers are agreed that further studies are needed, specifically fully blinded randomised controlled trials, to confirm or refute claims made in the published study. At this stage patients with low back pain should not consent to anti-biotic treatment without proper assessment and investigation under the care of a qualified spine surgeon or physician.

Scientist Hanne Albert at a large back center in Europe, the Spine Centre of Southern Denmark led by Professor Claus Manniche, performed studies that have showed that 80% of patients with Modic changes type 1 are cured or much improved after a cheap and simple antibiotic treatment.[63]

However, a more recent double blind, placebo-controlled, multicenter study from 2019 shows no evidence for the effect of antibiotics on back pain with Modic changes.[64]

References

  1. ^ Jensen, Tue Secher; Karppinen, Jaro; Sorensen, Joan S.; Niinimäki, Jaakko; Leboeuf-Yde, Charlotte (November 2008). "Vertebral endplate signal changes (Modic change): a systematic literature review of prevalence and association with non-specific low back pain". European Spine Journal. 17 (11): 1407–1422. doi:10.1007/s00586-008-0770-2. PMC 2583186. PMID 18787845.
  2. ^ Arnbak, Bodil; Jurik, Anne G.; Jensen, Tue S.; Manniche, Claus (February 2018). "Association Between Inflammatory Back Pain Characteristics and Magnetic Resonance Imaging Findings in the Spine and Sacroiliac Joints". Arthritis Care & Research. 70 (2): 244–251. doi:10.1002/acr.23259. PMID 28426912. S2CID 21199975.
  3. ^ Mok, Florence P.S.; Samartzis, Dino; Karppinen, Jaro; Fong, Daniel Y.T.; Luk, Keith D.K.; Cheung, Kenneth M.C. (January 2016). "Modic changes of the lumbar spine: prevalence, risk factors, and association with disc degeneration and low back pain in a large-scale population-based cohort". The Spine Journal. 16 (1): 32–41. doi:10.1016/j.spinee.2015.09.060. PMID 26456851.
  4. ^ Kuisma, Mari; Karppinen, Jaro; Niinimäki, Jaakko; Ojala, Risto; Haapea, Marianne; Heliövaara, Markku; Korpelainen, Raija; Taimela, Simo; Natri, Antero; Tervonen, Osmo (May 2007). "Modic Changes in Endplates of Lumbar Vertebral Bodies: Prevalence and Association With Low Back and Sciatic Pain Among Middle-Aged Male Workers". Spine. 32 (10): 1116–1122. doi:10.1097/01.brs.0000261561.12944.ff. PMID 17471095. S2CID 37327051.
  5. ^ Jensen, Tue Secher; Karppinen, Jaro; Sorensen, Joan S.; Niinimäki, Jaakko; Leboeuf-Yde, Charlotte (November 2008). "Vertebral endplate signal changes (Modic change): a systematic literature review of prevalence and association with non-specific low back pain". European Spine Journal. 17 (11): 1407–1422. doi:10.1007/s00586-008-0770-2. PMC 2583186. PMID 18787845.
  6. ^ Kjaer, Per; Korsholm, Lars; Bendix, Tom; Sorensen, Joan S.; Leboeuf-Yde, Charlotte (September 2006). "Modic changes and their associations with clinical findings". European Spine Journal. 15 (9): 1312–1319. doi:10.1007/s00586-006-0185-x. PMC 2438570. PMID 16896838.
  7. ^ Albert, Hanne B.; Briggs, Andrew M.; Kent, Peter; Byrhagen, Andreas; Hansen, Christian; Kjaergaard, Karina (August 2011). "The prevalence of MRI-defined spinal pathoanatomies and their association with Modic changes in individuals seeking care for low back pain". European Spine Journal. 20 (8): 1355–1362. doi:10.1007/s00586-011-1794-6. PMC 3175840. PMID 21544595.
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  10. ^ Arnbak, Bodil; Jurik, Anne G.; Jensen, Tue S.; Manniche, Claus (February 2018). "Association Between Inflammatory Back Pain Characteristics and Magnetic Resonance Imaging Findings in the Spine and Sacroiliac Joints". Arthritis Care & Research. 70 (2): 244–251. doi:10.1002/acr.23259.
  11. ^ Bailly, F.; Maigne, J.-Y.; Genevay, S.; Marty, M.; Gandjbakhch, F.; Rozenberg, S.; Foltz, V. (March 2014). "Inflammatory pain pattern and pain with lumbar extension associated with Modic 1 changes on MRI: a prospective case–control study of 120 patients". European Spine Journal. 23 (3): 493–497. doi:10.1007/s00586-013-3036-6.
  12. ^ Arnbak, Bodil; Jurik, Anne G.; Jensen, Tue S.; Manniche, Claus (February 2018). "Association Between Inflammatory Back Pain Characteristics and Magnetic Resonance Imaging Findings in the Spine and Sacroiliac Joints". Arthritis Care & Research. 70 (2): 244–251. doi:10.1002/acr.23259.
  13. ^ Bailly, F.; Maigne, J.-Y.; Genevay, S.; Marty, M.; Gandjbakhch, F.; Rozenberg, S.; Foltz, V. (March 2014). "Inflammatory pain pattern and pain with lumbar extension associated with Modic 1 changes on MRI: a prospective case–control study of 120 patients". European Spine Journal. 23 (3): 493–497. doi:10.1007/s00586-013-3036-6.
  14. ^ Arnbak, Bodil; Jurik, Anne G.; Jensen, Tue S.; Manniche, Claus (February 2018). "Association Between Inflammatory Back Pain Characteristics and Magnetic Resonance Imaging Findings in the Spine and Sacroiliac Joints". Arthritis Care & Research. 70 (2): 244–251. doi:10.1002/acr.23259.
  15. ^ Bailly, F.; Maigne, J.-Y.; Genevay, S.; Marty, M.; Gandjbakhch, F.; Rozenberg, S.; Foltz, V. (March 2014). "Inflammatory pain pattern and pain with lumbar extension associated with Modic 1 changes on MRI: a prospective case–control study of 120 patients". European Spine Journal. 23 (3): 493–497. doi:10.1007/s00586-013-3036-6.
  16. ^ Arnbak, Bodil; Jurik, Anne G.; Jensen, Tue S.; Manniche, Claus (February 2018). "Association Between Inflammatory Back Pain Characteristics and Magnetic Resonance Imaging Findings in the Spine and Sacroiliac Joints". Arthritis Care & Research. 70 (2): 244–251. doi:10.1002/acr.23259.
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  34. ^ Crock, HV (July 1986). "Internal disc disruption. A challenge to disc prolapse fifty years on". Spine. 11 (6): 650–3. PMID 3787337.
  35. ^ Mok, Florence P.S.; Samartzis, Dino; Karppinen, Jaro; Fong, Daniel Y.T.; Luk, Keith D.K.; Cheung, Kenneth M.C. (January 2016). "Modic changes of the lumbar spine: prevalence, risk factors, and association with disc degeneration and low back pain in a large-scale population-based cohort". The Spine Journal. 16 (1): 32–41. doi:10.1016/j.spinee.2015.09.060. PMID 26456851.
  36. ^ Kuisma, Mari; Karppinen, Jaro; Niinimäki, Jaakko; Ojala, Risto; Haapea, Marianne; Heliövaara, Markku; Korpelainen, Raija; Taimela, Simo; Natri, Antero; Tervonen, Osmo (May 2007). "Modic Changes in Endplates of Lumbar Vertebral Bodies: Prevalence and Association With Low Back and Sciatic Pain Among Middle-Aged Male Workers". Spine. 32 (10): 1116–1122. doi:10.1097/01.brs.0000261561.12944.ff. PMID 17471095. S2CID 37327051.
  37. ^ Jensen, Tue Secher; Karppinen, Jaro; Sorensen, Joan S.; Niinimäki, Jaakko; Leboeuf-Yde, Charlotte (November 2008). "Vertebral endplate signal changes (Modic change): a systematic literature review of prevalence and association with non-specific low back pain". European Spine Journal. 17 (11): 1407–1422. doi:10.1007/s00586-008-0770-2. PMC 2583186. PMID 18787845.
  38. ^ Kjaer, Per; Korsholm, Lars; Bendix, Tom; Sorensen, Joan S.; Leboeuf-Yde, Charlotte (September 2006). "Modic changes and their associations with clinical findings". European Spine Journal. 15 (9): 1312–1319. doi:10.1007/s00586-006-0185-x. PMC 2438570. PMID 16896838.
  39. ^ Albert, Hanne B.; Briggs, Andrew M.; Kent, Peter; Byrhagen, Andreas; Hansen, Christian; Kjaergaard, Karina (August 2011). "The prevalence of MRI-defined spinal pathoanatomies and their association with Modic changes in individuals seeking care for low back pain". European Spine Journal. 20 (8): 1355–1362. doi:10.1007/s00586-011-1794-6. PMC 3175840. PMID 21544595.
  40. ^ "World". The World Factbook. Central Intelligence Agency. 26 May 2022. Retrieved 6 June 2022.
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Bibliography

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