TEX14: Difference between revisions

TEX14
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	3WUT, 3WUU
Identifiers
Aliases	TEX14, CT113, testis expressed 14, intercellular bridge forming factor, SPGF23
External IDs	OMIM: 605792; MGI: 1933227; HomoloGene: 12838; GeneCards: TEX14; OMA:TEX14 - orthologs
Gene location (Human)
Chr.	Chromosome 17 (human)
End	58,692,055 bp
Gene location (Mouse)
Chr.	Chromosome 11 (mouse)
End	87,446,649 bp
RNA expression pattern
	Top expressed in
	right testis; ; left testis; ; gonad; ; oocyte; ; secondary oocyte; ; testicle; ; sperm; ; cerebellar cortex; ; cerebellar hemisphere; ; right hemisphere of cerebellum;
	Top expressed in
	spermatocyte; ; spermatid; ; seminiferous tubule; ; zygote; ; Gonadal ridge; ; secondary oocyte; ; ovary; ; primary oocyte; ; cumulus cell; ; morula;
	More reference expression data
	n/a
Gene ontology
Molecular function	protein binding; nucleotide binding; protein kinase binding; protein kinase activity; ATP binding;
Cellular component	cytoplasm; chromosome; chromosome, centromeric region; extracellular exosome; intercellular bridge; midbody; kinetochore;
Biological process	cell cycle; negative regulation of cytokinesis; cell division; protein phosphorylation; negative regulation of protein binding; mitotic spindle assembly checkpoint signaling; male meiotic nuclear division; intercellular bridge organization; attachment of spindle microtubules to kinetochore; mitotic sister chromatid separation; cellular response to leukemia inhibitory factor;
	Sources:Amigo / QuickGO
Orthologs
	56155
	83560
	ENSG00000121101
	ENSMUSG00000010342
	Q8IWB6
	Q7M6U3
	NM_001201457; NM_031272; NM_198393
	NM_001199293; NM_031386
	NP_001188386; NP_112562; NP_938207
	NP_001186222; NP_113563
	Wikidata
View/Edit Human	View/Edit Mouse

Browse history interactively

Next edit →

Content deleted Content added

VisualWikitext

Inline

Revision as of 00:53, 28 September 2022

Testis-expressed Protein 14 is a protein in humans encoded by the TEX14 gene, and is 1497 amino acids in length^[5]. TEX14 plays a vital role in the formation of germ cells, as it is an essential component of the mammalian germ cell interphase bridge.^[6]

An orthologue of TEX14 exists in other mammals, also called TEX14.

Clinical significance

Male mice^[6] and male pigs^[7] that lack normal TEX14 are incapable of producing functional sperm, and so TEX14 is theorised to be involved in human infertility.

References

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000121101 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000010342 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "TEX14 Gene - GeneCards | TEX14 Protein | TEX14 Antibody". www.genecards.org. Retrieved 2022-09-28.
^ ^a ^b Greenbaum, Michael P.; Yan, Wei; Wu, Meng-Hsieh; Lin, Yi-Nan; Agno, Julio E.; Sharma, Manju; Braun, Robert E.; Rajkovic, Aleksandar; Matzuk, Martin M. (2006-03-28). "TEX14 is essential for intercellular bridges and fertility in male mice". Proceedings of the National Academy of Sciences. 103 (13): 4982–4987. doi:10.1073/pnas.0505123103. ISSN 0027-8424. PMC 1458781. PMID 16549803.{{cite journal}}: CS1 maint: PMC format (link)
^ Sironen, Anu; Uimari, Pekka; Venhoranta, Heli; Andersson, Magnus; Vilkki, Johanna (2011-12-02). "An exonic insertion within Tex14 gene causes spermatogenic arrest in pigs". BMC Genomics. 12 (1): 591. doi:10.1186/1471-2164-12-591. ISSN 1471-2164. PMC 3248578. PMID 22136159.{{cite journal}}: CS1 maint: PMC format (link) CS1 maint: unflagged free DOI (link)

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000121101 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000010342 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[5] "TEX14 Gene - GeneCards | TEX14 Protein | TEX14 Antibody". www.genecards.org. Retrieved 2022-09-28.

[:0-6] Greenbaum, Michael P.; Yan, Wei; Wu, Meng-Hsieh; Lin, Yi-Nan; Agno, Julio E.; Sharma, Manju; Braun, Robert E.; Rajkovic, Aleksandar; Matzuk, Martin M. (2006-03-28). "TEX14 is essential for intercellular bridges and fertility in male mice". Proceedings of the National Academy of Sciences. 103 (13): 4982–4987. doi:10.1073/pnas.0505123103. ISSN 0027-8424. PMC 1458781. PMID 16549803.{{cite journal}}: CS1 maint: PMC format (link)

[7] Sironen, Anu; Uimari, Pekka; Venhoranta, Heli; Andersson, Magnus; Vilkki, Johanna (2011-12-02). "An exonic insertion within Tex14 gene causes spermatogenic arrest in pigs". BMC Genomics. 12 (1): 591. doi:10.1186/1471-2164-12-591. ISSN 1471-2164. PMC 3248578. PMID 22136159.{{cite journal}}: CS1 maint: PMC format (link) CS1 maint: unflagged free DOI (link)

[1]

[2]

[3]

[4]

[5]

[6]

[7]

@@ Line 1: / Line 1: @@
-{{#invoke:Infobox_gene|getTemplateData|QID=Q18042303}}'''Testis-expressed Protein 14''' is a [[protein]] in humans encoded by the TEX14 gene, and is 1497 [[Amino acid|amino acids]] in length<ref>{{Cite web |title=TEX14 Gene - GeneCards {{!}} TEX14 Protein {{!}} TEX14 Antibody |url=https://www.genecards.org/cgi-bin/carddisp.pl?gene=TEX14 |access-date=2022-09-28 |website=www.genecards.org}}</ref>. TEX14 plays a vital role in the formation of [[Germ cell|germ cells]], as it is an essential component of the mammalian germ cell interphase bridge.<ref>{{Cite journal |last=Greenbaum |first=Michael P. |last2=Yan |first2=Wei |last3=Wu |first3=Meng-Hsieh |last4=Lin |first4=Yi-Nan |last5=Agno |first5=Julio E. |last6=Sharma |first6=Manju |last7=Braun |first7=Robert E. |last8=Rajkovic |first8=Aleksandar |last9=Matzuk |first9=Martin M. |date=2006-03-28 |title=TEX14 is essential for intercellular bridges and fertility in male mice |url=https://pnas.org/doi/full/10.1073/pnas.0505123103 |journal=Proceedings of the National Academy of Sciences |language=en |volume=103 |issue=13 |pages=4982–4987 |doi=10.1073/pnas.0505123103 |issn=0027-8424 |pmc=PMC1458781 |pmid=16549803}}</ref>
+{{#invoke:Infobox_gene|getTemplateData|QID=Q18042303}}'''Testis-expressed Protein 14''' is a [[protein]] in humans encoded by the TEX14 gene, and is 1497 [[Amino acid|amino acids]] in length<ref>{{Cite web |title=TEX14 Gene - GeneCards {{!}} TEX14 Protein {{!}} TEX14 Antibody |url=https://www.genecards.org/cgi-bin/carddisp.pl?gene=TEX14 |access-date=2022-09-28 |website=www.genecards.org}}</ref>. TEX14 plays a vital role in the formation of [[Germ cell|germ cells]], as it is an essential component of the mammalian germ cell interphase bridge.<ref name=":0">{{Cite journal |last=Greenbaum |first=Michael P. |last2=Yan |first2=Wei |last3=Wu |first3=Meng-Hsieh |last4=Lin |first4=Yi-Nan |last5=Agno |first5=Julio E. |last6=Sharma |first6=Manju |last7=Braun |first7=Robert E. |last8=Rajkovic |first8=Aleksandar |last9=Matzuk |first9=Martin M. |date=2006-03-28 |title=TEX14 is essential for intercellular bridges and fertility in male mice |url=https://pnas.org/doi/full/10.1073/pnas.0505123103 |journal=Proceedings of the National Academy of Sciences |language=en |volume=103 |issue=13 |pages=4982–4987 |doi=10.1073/pnas.0505123103 |issn=0027-8424 |pmc=PMC1458781 |pmid=16549803}}</ref>
-An orthologue of TEX14 exists in mice, also called TEX14.
+An orthologue of TEX14 exists in other mammals, also called TEX14.
+== Clinical significance ==
+Male mice<ref name=":0" /> and male pigs<ref>{{Cite journal |last=Sironen |first=Anu |last2=Uimari |first2=Pekka |last3=Venhoranta |first3=Heli |last4=Andersson |first4=Magnus |last5=Vilkki |first5=Johanna |date=2011-12-02 |title=An exonic insertion within Tex14 gene causes spermatogenic arrest in pigs |url=https://doi.org/10.1186/1471-2164-12-591 |journal=BMC Genomics |volume=12 |issue=1 |pages=591 |doi=10.1186/1471-2164-12-591 |issn=1471-2164 |pmc=PMC3248578 |pmid=22136159}}</ref> that lack normal TEX14 are incapable of producing functional sperm, and so TEX14 is theorised to be involved in human infertility.