Phenicarbazide: Difference between revisions
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'''Phenicarbazide''' is a [[semicarbazide]] and an [[antipyretic]] substance. It is carcinogenic in mice.<ref name="phenicarbazide">[http://www.inchem.org/documents/iarc/vol12/phenicarbazide.html Phenicarbazide]</ref> |
'''Phenicarbazide''' is a [[semicarbazide]] and an [[antipyretic]] substance. It is carcinogenic in mice.<ref name="phenicarbazide">[http://www.inchem.org/documents/iarc/vol12/phenicarbazide.html Phenicarbazide]</ref> |
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== Preparation == |
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Phenicarbazide can be obtained by mixing [[phenylhydrazine]] with [[acetic acid]] in aqueous solution with the addition of [[potassium cyanide]]. It is also obtained from the reaction of phenylhydrazine with [[urea]].<ref>{{Cite book |last=Bruchhausen |first=Franz |url=https://www.worldcat.org/oclc/913646782 |title=Hagers Handbuch der Pharmazeutischen Praxis : Stoffe L-Z Folgeband 5 |date=1999 |others=Siegfried Ebel, Eberhard Hackenthal, Ulrike Holzgrabe, Margitta Albinus, Gudrun Amschler, Erwin Angerer |isbn=978-3-642-58388-9 |edition=5. vollständig neubearbeitete Auflage |location=Berlin, Heidelberg |pages=420 |oclc=913646782}}</ref> |
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== Properties == |
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Phenicarbazide is a flammable, hard to ignite, crystalline, beige solid that is practically insoluble in water. It decomposes on heating.<ref>{{Cite web |title=Phenicarbazid |url=https://gestis.dguv.de/data?name=031670 |access-date=2022-10-18 |website=GESTIS-Stoffdatenbank}}</ref> |
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== Uses == |
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Phenicarbazide is an intermediate in the syntheses of a series of chemical compounds by cyclocondensation reactions.<ref>{{Cite web |title=1-Phenylsemicarbazide |url=https://www.sigmaaldrich.com/US/en/product/aldrich/245909 |website=Sigma-Aldrich}}</ref> It was investigated as an [[analgesic]] and [[antipyretic]] in the 1970s and was used in combination preparations. |
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== References == |
== References == |
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Revision as of 05:01, 18 October 2022
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| Clinical data | |
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| Other names | 1-Phenylsemicarbazide; Kryogenin |
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| CompTox Dashboard (EPA) | |
| ECHA InfoCard | 100.002.794 |
| Chemical and physical data | |
| Formula | C7H9N3O |
| Molar mass | 151.169 g·mol−1 |
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Phenicarbazide is a semicarbazide and an antipyretic substance. It is carcinogenic in mice.[1]
Preparation
Phenicarbazide can be obtained by mixing phenylhydrazine with acetic acid in aqueous solution with the addition of potassium cyanide. It is also obtained from the reaction of phenylhydrazine with urea.[2]
Properties
Phenicarbazide is a flammable, hard to ignite, crystalline, beige solid that is practically insoluble in water. It decomposes on heating.[3]
Uses
Phenicarbazide is an intermediate in the syntheses of a series of chemical compounds by cyclocondensation reactions.[4] It was investigated as an analgesic and antipyretic in the 1970s and was used in combination preparations.
References
- ^ Phenicarbazide
- ^ Bruchhausen, Franz (1999). Hagers Handbuch der Pharmazeutischen Praxis : Stoffe L-Z Folgeband 5. Siegfried Ebel, Eberhard Hackenthal, Ulrike Holzgrabe, Margitta Albinus, Gudrun Amschler, Erwin Angerer (5. vollständig neubearbeitete Auflage ed.). Berlin, Heidelberg. p. 420. ISBN 978-3-642-58388-9. OCLC 913646782.
{{cite book}}: CS1 maint: location missing publisher (link) - ^ "Phenicarbazid". GESTIS-Stoffdatenbank. Retrieved 2022-10-18.
- ^ "1-Phenylsemicarbazide". Sigma-Aldrich.
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