Neuron derived neurotrophic factor: Difference between revisions
Content deleted Content added
Importing Wikidata short description: Protein-coding gene in the species Homo sapiens (shortdescs-in-category) |
Changed the wording of the description of the gene and also added more information about what the protein does in the body. |
||
| Line 1: | Line 1: | ||
{{Short description|Protein-coding gene in the species Homo sapiens}} |
{{Short description|Protein-coding gene in the species Homo sapiens}} |
||
[[File:Protein Structure of human NDNF.png|thumb|3D protein structure of the NDNF gene as based on the alpha fold model.]] |
|||
{{Infobox_gene}} |
{{Infobox_gene}} |
||
Neuron derived neurotrophic factor (''NDNF'') is a secreted protein that, in humans, is located on chromosome 4 <ref>{{Cite web |title=NDNF neuron derived neurotrophic factor [Homo sapiens (human)] - Gene - NCBI |url=https://www.ncbi.nlm.nih.gov/gene/79625 |access-date=2023-05-12 |website=www.ncbi.nlm.nih.gov}}</ref>. This protein helps in the growth, survival, migration, and differentiation of neurons <ref>{{Cite journal |last=Kuang |first=Xiu-Li |last2=Zhao |first2=Xiao-Mei |last3=Xu |first3=Hai-Fang |last4=Shi |first4=Yuan-Yuan |last5=Deng |first5=Jin-Bo |last6=Sun |first6=Guo-Tao |date=2010-10-25 |title=Spatio-temporal expression of a novel neuron-derived neurotrophic factor (NDNF) in mouse brains during development |url=https://doi.org/10.1186/1471-2202-11-137 |journal=BMC Neuroscience |volume=11 |issue=1 |pages=137 |doi=10.1186/1471-2202-11-137 |issn=1471-2202 |pmc=PMC2984559 |pmid=20969804}}</ref>. To assist with migration, ''NDNF'' shows neuro-repulsive effects on GnRH neurons. Loss of function (LoF) in the ''NDNF'' gene has been shown to be a cause of a disease known as congenital hypogonadotropic hypogonadism, which can have associated cleft lip and cleft palate <ref>{{Cite journal |last=Messina |first=Andrea |last2=Pulli |first2=Kristiina |last3=Santini |first3=Sara |last4=Acierno |first4=James |last5=Känsäkoski |first5=Johanna |last6=Cassatella |first6=Daniele |last7=Xu |first7=Cheng |last8=Casoni |first8=Filippo |last9=Malone |first9=Samuel A. |last10=Ternier |first10=Gaetan |last11=Conte |first11=Daniele |last12=Sidis |first12=Yisrael |last13=Tommiska |first13=Johanna |last14=Vaaralahti |first14=Kirsi |last15=Dwyer |first15=Andrew |date=2020-01-02 |title=Neuron-Derived Neurotrophic Factor Is Mutated in Congenital Hypogonadotropic Hypogonadism |url=https://pubmed.ncbi.nlm.nih.gov/31883645/ |journal=American Journal of Human Genetics |volume=106 |issue=1 |pages=58–70 |doi=10.1016/j.ajhg.2019.12.003 |issn=1537-6605 |pmc=7042563 |pmid=31883645}}</ref>. A preliminary study has shown that knock-down of ''ndnf'' reduces development of the ethmoid plate, which is homologous to the human palate <ref>{{Cite journal |last=Swartz |first=Mary E. |last2=Sheehan-Rooney |first2=Kelly |last3=Dixon |first3=Michael J. |last4=Eberhart |first4=Johann K. |date=2011-09 |title=Examination of a palatogenic gene program in zebrafish |url=https://pubmed.ncbi.nlm.nih.gov/22016187/ |journal=Developmental Dynamics: An Official Publication of the American Association of Anatomists |volume=240 |issue=9 |pages=2204–2220 |doi=10.1002/dvdy.22713 |issn=1097-0177 |pmc=3202344 |pmid=22016187}}</ref><ref>{{Cite journal |last=Melvin |first=Vida Senkus |last2=Feng |first2=Weiguo |last3=Hernandez-Lagunas |first3=Laura |last4=Artinger |first4=Kristin Bruk |last5=Williams |first5=Trevor |date=2013-07 |title=A morpholino-based screen to identify novel genes involved in craniofacial morphogenesis |url=https://pubmed.ncbi.nlm.nih.gov/23559552/ |journal=Developmental Dynamics: An Official Publication of the American Association of Anatomists |volume=242 |issue=7 |pages=817–831 |doi=10.1002/dvdy.23969 |issn=1097-0177 |pmc=4027977 |pmid=23559552}}</ref>. |
|||
'''Neuron derived neurotrophic factor''' is a [[protein]] that in humans is encoded by the NDNF [[gene]]. |
|||
<ref name="entrez"> |
|||
{{cite web |
|||
| title = Entrez Gene: Neuron derived neurotrophic factor |
|||
| url = https://www.ncbi.nlm.nih.gov/gene/79625 |
|||
| access-date = 2017-06-27 |
|||
}}</ref> |
|||
== References == |
== References == |
||
Revision as of 21:07, 12 May 2023
Neuron derived neurotrophic factor (NDNF) is a secreted protein that, in humans, is located on chromosome 4 [5]. This protein helps in the growth, survival, migration, and differentiation of neurons [6]. To assist with migration, NDNF shows neuro-repulsive effects on GnRH neurons. Loss of function (LoF) in the NDNF gene has been shown to be a cause of a disease known as congenital hypogonadotropic hypogonadism, which can have associated cleft lip and cleft palate [7]. A preliminary study has shown that knock-down of ndnf reduces development of the ethmoid plate, which is homologous to the human palate [8][9].
References
- ^ a b c GRCh38: Ensembl release 89: ENSG00000173376 – Ensembl, May 2017
- ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000049001 – Ensembl, May 2017
- ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
- ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
- ^ "NDNF neuron derived neurotrophic factor [Homo sapiens (human)] - Gene - NCBI". www.ncbi.nlm.nih.gov. Retrieved 2023-05-12.
- ^ Kuang, Xiu-Li; Zhao, Xiao-Mei; Xu, Hai-Fang; Shi, Yuan-Yuan; Deng, Jin-Bo; Sun, Guo-Tao (2010-10-25). "Spatio-temporal expression of a novel neuron-derived neurotrophic factor (NDNF) in mouse brains during development". BMC Neuroscience. 11 (1): 137. doi:10.1186/1471-2202-11-137. ISSN 1471-2202. PMC 2984559. PMID 20969804.
{{cite journal}}: CS1 maint: PMC format (link) CS1 maint: unflagged free DOI (link) - ^ Messina, Andrea; Pulli, Kristiina; Santini, Sara; Acierno, James; Känsäkoski, Johanna; Cassatella, Daniele; Xu, Cheng; Casoni, Filippo; Malone, Samuel A.; Ternier, Gaetan; Conte, Daniele; Sidis, Yisrael; Tommiska, Johanna; Vaaralahti, Kirsi; Dwyer, Andrew (2020-01-02). "Neuron-Derived Neurotrophic Factor Is Mutated in Congenital Hypogonadotropic Hypogonadism". American Journal of Human Genetics. 106 (1): 58–70. doi:10.1016/j.ajhg.2019.12.003. ISSN 1537-6605. PMC 7042563. PMID 31883645.
- ^ Swartz, Mary E.; Sheehan-Rooney, Kelly; Dixon, Michael J.; Eberhart, Johann K. (2011-09). "Examination of a palatogenic gene program in zebrafish". Developmental Dynamics: An Official Publication of the American Association of Anatomists. 240 (9): 2204–2220. doi:10.1002/dvdy.22713. ISSN 1097-0177. PMC 3202344. PMID 22016187.
{{cite journal}}: Check date values in:|date=(help) - ^ Melvin, Vida Senkus; Feng, Weiguo; Hernandez-Lagunas, Laura; Artinger, Kristin Bruk; Williams, Trevor (2013-07). "A morpholino-based screen to identify novel genes involved in craniofacial morphogenesis". Developmental Dynamics: An Official Publication of the American Association of Anatomists. 242 (7): 817–831. doi:10.1002/dvdy.23969. ISSN 1097-0177. PMC 4027977. PMID 23559552.
{{cite journal}}: Check date values in:|date=(help)
Further reading
- Utine GE, Aktas D (2006). "Mosaicism for terminal deletion of 4q". Genet. Couns. 17 (2): 205–9. PMID 16970039.
- Kalsi G, Kuo PH, Aliev F, Alexander J, McMichael O, Patterson DG, Walsh D, Zhao Z, Schuckit M, Nurnberger J, Edenberg H, Kramer J, Hesselbrock V, Tischfield JA, Vladimirov V, Prescott CA, Dick DM, Kendler KS, Riley BP (2010). "A systematic gene-based screen of chr4q22-q32 identifies association of a novel susceptibility gene, DKK2, with the quantitative trait of alcohol dependence symptom counts". Hum. Mol. Genet. 19 (12): 2497–506. doi:10.1093/hmg/ddq112. PMC 2876884. PMID 20332099.
- Rose JE, Behm FM, Drgon T, Johnson C, Uhl GR (2010). "Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score". Mol. Med. 16 (7–8): 247–53. doi:10.2119/molmed.2009.00159. PMC 2896464. PMID 20379614.
 | This article on a gene on human chromosome 4 is a stub. You can help Wikipedia by expanding it. |