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'''BAM15''' is a novel mitochondrial protonophore uncoupler capable of protecting mammals from acute renal ischemic-reperfusion injury and cold-induced microtubule damage.<ref>{{cite journal |title=Mitochondrial uncoupler BAM15 reverses diet-induced obesity and insulin resistance in mice |journal=Nature Communications |year=2020 |doi=10.1038/s41467-020-16298-2 |last1=Alexopoulos |first1=Stephanie J. |last2=Chen |first2=Sing-Young |last3=Brandon |first3=Amanda E. |last4=Salamoun |first4=Joseph M. |last5=Byrne |first5=Frances L. |last6=Garcia |first6=Christopher J. |last7=Beretta |first7=Martina |last8=Olzomer |first8=Ellen M. |last9=Shah |first9=Divya P. |last10=Philp |first10=Ashleigh M. |last11=Hargett |first11=Stefan R. |last12=Lawrence |first12=Robert T. |last13=Lee |first13=Brendan |last14=Sligar |first14=James |last15=Carrive |first15=Pascal |last16=Tucker |first16=Simon P. |last17=Philp |first17=Andrew |last18=Lackner |first18=Carolin |last19=Turner |first19=Nigel |last20=Cooney |first20=Gregory J. |last21=Santos |first21=Webster L. |last22=Hoehn |first22=Kyle L. |volume=11 |issue=1 |page=2397 |pmid=32409697 |pmc=7224297 }}</ref><ref>{{cite web |title=A new study |url=https://medicalxpress.com/news/2020-06-bam15-potential-treatment-obesity.html |website=medicalxpress |accessdate=16 June 2020}}</ref>
'''BAM15''' is a novel mitochondrial protonophore [[uncoupler]] capable of protecting mammals from acute renal ischemic-reperfusion injury and cold-induced microtubule damage.<ref name=Tsuji>{{cite journal |last1=Tsuji |first1=Naoko |last2=Tsuji |first2=Takayuki |last3=Yamashita |first3=Tetsushi |last4=Hayase |first4=Naoki |last5=Hu |first5=Xuzhen |last6=Yuen |first6=Peter S. T. |last7=Star |first7=Robert A. |title=BAM15 treats mouse sepsis and kidney injury, linking mortality, mitochondrial DNA, tubule damage, and neutrophils |journal=The Journal of Clinical Investigation |date=3 April 2023 |volume=133 |issue=7 |doi=10.1172/JCI152401 |url=https://www.jci.org/articles/view/152401 |language=en |issn=0021-9738}}</ref><ref>{{cite journal |title=Mitochondrial uncoupler BAM15 reverses diet-induced obesity and insulin resistance in mice |journal=Nature Communications |year=2020 |doi=10.1038/s41467-020-16298-2 |last1=Alexopoulos |first1=Stephanie J. |last2=Chen |first2=Sing-Young |last3=Brandon |first3=Amanda E. |last4=Salamoun |first4=Joseph M. |last5=Byrne |first5=Frances L. |last6=Garcia |first6=Christopher J. |last7=Beretta |first7=Martina |last8=Olzomer |first8=Ellen M. |last9=Shah |first9=Divya P. |last10=Philp |first10=Ashleigh M. |last11=Hargett |first11=Stefan R. |last12=Lawrence |first12=Robert T. |last13=Lee |first13=Brendan |last14=Sligar |first14=James |last15=Carrive |first15=Pascal |last16=Tucker |first16=Simon P. |last17=Philp |first17=Andrew |last18=Lackner |first18=Carolin |last19=Turner |first19=Nigel |last20=Cooney |first20=Gregory J. |last21=Santos |first21=Webster L. |last22=Hoehn |first22=Kyle L. |volume=11 |issue=1 |page=2397 |pmid=32409697 |pmc=7224297 }}</ref> It is being studied for the treatment of obesity<ref>{{cite journal |last1=Axelrod |first1=Christopher L |last2=King |first2=William T |last3=Davuluri |first3=Gangarao |last4=Noland |first4=Robert C |last5=Hall |first5=Jacob |last6=Hull |first6=Michaela |last7=Dantas |first7=Wagner S |last8=Zunica |first8=Elizabeth RM |last9=Alexopoulos |first9=Stephanie J |last10=Hoehn |first10=Kyle L |last11=Langohr |first11=Ingeborg |last12=Stadler |first12=Krisztian |last13=Doyle |first13=Haylee |last14=Schmidt |first14=Eva |last15=Nieuwoudt |first15=Stephan |last16=Fitzgerald |first16=Kelly |last17=Pergola |first17=Kathryn |last18=Fujioka |first18=Hisashi |last19=Mey |first19=Jacob T |last20=Fealy |first20=Ciaran |last21=Mulya |first21=Anny |last22=Beyl |first22=Robbie |last23=Hoppel |first23=Charles L |last24=Kirwan |first24=John P |title=BAM15‐mediated mitochondrial uncoupling protects against obesity and improves glycemic control |journal=EMBO Molecular Medicine |date=7 July 2020 |volume=12 |issue=7 |pages=e12088 |doi=10.15252/emmm.202012088 |url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7338798/ |issn=1757-4676}}</ref> [[sepsis]],<ref name=Tsuji/><ref>{{cite journal |last1=Dang |first1=Cong Phi |last2=Issara-Amphorn |first2=Jiraphorn |last3=Charoensappakit |first3=Awirut |last4=Udompornpitak |first4=Kanyarat |last5=Bhunyakarnjanarat |first5=Thansita |last6=Saisorn |first6=Wilasinee |last7=Sae-Khow |first7=Kritsanawan |last8=Leelahavanichkul |first8=Asada |title=BAM15, a Mitochondrial Uncoupling Agent, Attenuates Inflammation in the LPS Injection Mouse Model: An Adjunctive Anti-Inflammation on Macrophages and Hepatocytes |journal=Journal of Innate Immunity |date=1 June 2021 |volume=13 |issue=6 |pages=359–375 |doi=10.1159/000516348 |url=https://karger.com/jin/article/13/6/359/824259/BAM15-a-Mitochondrial-Uncoupling-Agent-Attenuates |issn=1662-811X}}</ref> and cancer.<ref>{{cite journal |last1=Gao |first1=Zhen xing |last2=Cui |first2=Ze long |last3=Zhou |first3=Min ran |last4=Fu |first4=Yue |last5=Liu |first5=Fen |last6=Zhang |first6=Lu |last7=Ma |first7=Sai |last8=Chen |first8=Chun yan |title=The new mitochondrial uncoupler BAM15 induces ROS production for treatment of acute myeloid leukemia |journal=Biochemical Pharmacology |date=1 April 2022 |volume=198 |pages=114948 |doi=10.1016/j.bcp.2022.114948 |url=https://www.sciencedirect.com/science/article/abs/pii/S0006295222000429 |issn=0006-2952}}</ref><ref>{{cite journal |last1=Zunica |first1=Elizabeth R. M. |last2=Axelrod |first2=Christopher L. |last3=Cho |first3=Eunhan |last4=Spielmann |first4=Guillaume |last5=Davuluri |first5=Gangarao |last6=Alexopoulos |first6=Stephanie J. |last7=Beretta |first7=Martina |last8=Hoehn |first8=Kyle L. |last9=Dantas |first9=Wagner S. |last10=Stadler |first10=Krisztian |last11=King |first11=William T. |last12=Pergola |first12=Kathryn |last13=Irving |first13=Brian A. |last14=Langohr |first14=Ingeborg M. |last15=Yang |first15=Shengping |last16=Hoppel |first16=Charles L. |last17=Gilmore |first17=L. Anne |last18=Kirwan |first18=John P. |title=Breast cancer growth and proliferation is suppressed by the mitochondrial targeted furazano[3,4-b]pyrazine BAM15 |journal=Cancer & Metabolism |date=9 October 2021 |volume=9 |issue=1 |pages=36 |doi=10.1186/s40170-021-00274-5 |url=https://cancerandmetabolism.biomedcentral.com/articles/10.1186/s40170-021-00274-5 |issn=2049-3002}}</ref>


== References ==
== References ==

Revision as of 04:22, 28 September 2023

BAM15
Names
Preferred IUPAC name
N5,N6-Bis(2-fluorophenyl)[2,1,3]oxadiazolo[4,5-b]pyrazine-5,6-diamine
Identifiers
3D model (JSmol)
ChEMBL
ChemSpider
  • InChI=1S/C16H10F2N6O/c17-9-5-1-3-7-11(9)19-13-14(20-12-8-4-2-6-10(12)18)22-16-15(21-13)23-25-24-16/h1-8H,(H,19,21,23)(H,20,22,24)
    Key: OEGJBRZAJRPPHL-UHFFFAOYSA-N
  • C1=CC=C(C(=C1)NC2=NC3=NON=C3N=C2NC4=CC=CC=C4F)F
Properties
C16H10F2N6O
Molar mass 340.294 g·mol−1
Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa).

BAM15 is a novel mitochondrial protonophore uncoupler capable of protecting mammals from acute renal ischemic-reperfusion injury and cold-induced microtubule damage.[1][2] It is being studied for the treatment of obesity[3] sepsis,[1][4] and cancer.[5][6]

References

  1. ^ a b Tsuji, Naoko; Tsuji, Takayuki; Yamashita, Tetsushi; Hayase, Naoki; Hu, Xuzhen; Yuen, Peter S. T.; Star, Robert A. (3 April 2023). "BAM15 treats mouse sepsis and kidney injury, linking mortality, mitochondrial DNA, tubule damage, and neutrophils". The Journal of Clinical Investigation. 133 (7). doi:10.1172/JCI152401. ISSN 0021-9738.
  2. ^ Alexopoulos, Stephanie J.; Chen, Sing-Young; Brandon, Amanda E.; Salamoun, Joseph M.; Byrne, Frances L.; Garcia, Christopher J.; Beretta, Martina; Olzomer, Ellen M.; Shah, Divya P.; Philp, Ashleigh M.; Hargett, Stefan R.; Lawrence, Robert T.; Lee, Brendan; Sligar, James; Carrive, Pascal; Tucker, Simon P.; Philp, Andrew; Lackner, Carolin; Turner, Nigel; Cooney, Gregory J.; Santos, Webster L.; Hoehn, Kyle L. (2020). "Mitochondrial uncoupler BAM15 reverses diet-induced obesity and insulin resistance in mice". Nature Communications. 11 (1): 2397. doi:10.1038/s41467-020-16298-2. PMC 7224297. PMID 32409697.
  3. ^ Axelrod, Christopher L; King, William T; Davuluri, Gangarao; Noland, Robert C; Hall, Jacob; Hull, Michaela; Dantas, Wagner S; Zunica, Elizabeth RM; Alexopoulos, Stephanie J; Hoehn, Kyle L; Langohr, Ingeborg; Stadler, Krisztian; Doyle, Haylee; Schmidt, Eva; Nieuwoudt, Stephan; Fitzgerald, Kelly; Pergola, Kathryn; Fujioka, Hisashi; Mey, Jacob T; Fealy, Ciaran; Mulya, Anny; Beyl, Robbie; Hoppel, Charles L; Kirwan, John P (7 July 2020). "BAM15‐mediated mitochondrial uncoupling protects against obesity and improves glycemic control". EMBO Molecular Medicine. 12 (7): e12088. doi:10.15252/emmm.202012088. ISSN 1757-4676.
  4. ^ Dang, Cong Phi; Issara-Amphorn, Jiraphorn; Charoensappakit, Awirut; Udompornpitak, Kanyarat; Bhunyakarnjanarat, Thansita; Saisorn, Wilasinee; Sae-Khow, Kritsanawan; Leelahavanichkul, Asada (1 June 2021). "BAM15, a Mitochondrial Uncoupling Agent, Attenuates Inflammation in the LPS Injection Mouse Model: An Adjunctive Anti-Inflammation on Macrophages and Hepatocytes". Journal of Innate Immunity. 13 (6): 359–375. doi:10.1159/000516348. ISSN 1662-811X.
  5. ^ Gao, Zhen xing; Cui, Ze long; Zhou, Min ran; Fu, Yue; Liu, Fen; Zhang, Lu; Ma, Sai; Chen, Chun yan (1 April 2022). "The new mitochondrial uncoupler BAM15 induces ROS production for treatment of acute myeloid leukemia". Biochemical Pharmacology. 198: 114948. doi:10.1016/j.bcp.2022.114948. ISSN 0006-2952.
  6. ^ Zunica, Elizabeth R. M.; Axelrod, Christopher L.; Cho, Eunhan; Spielmann, Guillaume; Davuluri, Gangarao; Alexopoulos, Stephanie J.; Beretta, Martina; Hoehn, Kyle L.; Dantas, Wagner S.; Stadler, Krisztian; King, William T.; Pergola, Kathryn; Irving, Brian A.; Langohr, Ingeborg M.; Yang, Shengping; Hoppel, Charles L.; Gilmore, L. Anne; Kirwan, John P. (9 October 2021). "Breast cancer growth and proliferation is suppressed by the mitochondrial targeted furazano[3,4-b]pyrazine BAM15". Cancer & Metabolism. 9 (1): 36. doi:10.1186/s40170-021-00274-5. ISSN 2049-3002.{{cite journal}}: CS1 maint: unflagged free DOI (link)

External links

Retrieved from "https://en.wikipedia.org/w/index.php?title=BAM15&oldid=1177558992"