ATF7IP: Difference between revisions
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==Interactions== |
==Interactions== |
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ATF7IP has been shown to [[Protein-protein interaction|interact]] with [[MBD1]].<ref name=pmid12665582>{{cite journal |last=Fujita |first=Naoyuki |author2=Watanabe Sugiko |author3=Ichimura Takaya |author4=Ohkuma Yoshiaki |author5=Chiba Tsutomu |author6=Saya Hideyuki |author7=Nakao Mitsuyoshi |date=Apr 2003 |title=MCAF Mediates MBD1-Dependent Transcriptional Repression |journal=Mol. Cell. Biol. |volume=23 |issue=8 |pages=2834–43 |location = United States| issn = 0270-7306| pmid = 12665582 |doi=10.1128/MCB.23.8.2834-2843.2003 |pmc=152570 }}</ref> |
ATF7IP has been shown to [[Protein-protein interaction|interact]] with [[MBD1]].<ref name=pmid12665582>{{cite journal |last=Fujita |first=Naoyuki |author2=Watanabe Sugiko |author3=Ichimura Takaya |author4=Ohkuma Yoshiaki |author5=Chiba Tsutomu |author6=Saya Hideyuki |author7=Nakao Mitsuyoshi |date=Apr 2003 |title=MCAF Mediates MBD1-Dependent Transcriptional Repression |journal=Mol. Cell. Biol. |volume=23 |issue=8 |pages=2834–43 |location = United States| issn = 0270-7306| pmid = 12665582 |doi=10.1128/MCB.23.8.2834-2843.2003 |pmc=152570 }}</ref> In mice with T cell-specific deletion of Atf7ip, the protein has been shown to play a role in regulating [[T helper 17 cell]] (Th17) differentiation due to increased [[Interleukin 2|IL-2]] production upon stimulation of the [[T-cell receptor|T cell receptor]] (TCR). This TCR stimulation occurs through deposition of [[H3K9me3]], a repressive [[histone]] mark<ref>{{Cite journal |last=Sin |first=Jun Hyung |last2=Zuckerman |first2=Cassandra |last3=Cortez |first3=Jessica T. |last4=Eckalbar |first4=Walter L. |last5=Erle |first5=David J. |last6=Anderson |first6=Mark S. |last7=Waterfield |first7=Michael R. |date=2019-09-02 |title=The epigenetic regulator ATF7ip inhibits Il2 expression, regulating Th17 responses |url=https://pubmed.ncbi.nlm.nih.gov/31217192 |journal=The Journal of Experimental Medicine |volume=216 |issue=9 |pages=2024–2037 |doi=10.1084/jem.20182316 |issn=1540-9538 |pmc=6719416 |pmid=31217192}}</ref><ref>{{Cite journal |last=Zhao |first=Zhipeng |last2=Feng |first2=Lu |last3=Peng |first3=Xuerun |last4=Ma |first4=Tingnan |last5=Tong |first5=Rongsheng |last6=Zhong |first6=Lei |date=2022 |title=Role of histone methyltransferase SETDB1 in regulation of tumourigenesis and immune response |url=https://pubmed.ncbi.nlm.nih.gov/36582533 |journal=Frontiers in Pharmacology |volume=13 |pages=1073713 |doi=10.3389/fphar.2022.1073713 |issn=1663-9812 |pmc=9793902 |pmid=36582533}}</ref>. |
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==References== |
==References== |
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Revision as of 07:18, 3 November 2023
Activating transcription factor 7-interacting protein 1 is a protein that in humans is encoded by the ATF7IP gene.[5][6][7]
Interactions
ATF7IP has been shown to interact with MBD1.[8] In mice with T cell-specific deletion of Atf7ip, the protein has been shown to play a role in regulating T helper 17 cell (Th17) differentiation due to increased IL-2 production upon stimulation of the T cell receptor (TCR). This TCR stimulation occurs through deposition of H3K9me3, a repressive histone mark[9][10].
References
- ^ a b c GRCh38: Ensembl release 89: ENSG00000171681 – Ensembl, May 2017
- ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000030213 – Ensembl, May 2017
- ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
- ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
- ^ Gunther M, Laithier M, Brison O (Dec 2000). "A set of proteins interacting with transcription factor Sp1 identified in a two-hybrid screening". Mol Cell Biochem. 210 (1–2): 131–42. doi:10.1023/A:1007177623283. PMID 10976766. S2CID 1339642.
- ^ De Graeve F, Bahr A, Chatton B, Kedinger C (Jun 2000). "A murine ATFa-associated factor with transcriptional repressing activity". Oncogene. 19 (14): 1807–19. doi:10.1038/sj.onc.1203492. PMID 10777215.
- ^ "Entrez Gene: ATF7IP activating transcription factor 7 interacting protein".
- ^ Fujita, Naoyuki; Watanabe Sugiko; Ichimura Takaya; Ohkuma Yoshiaki; Chiba Tsutomu; Saya Hideyuki; Nakao Mitsuyoshi (Apr 2003). "MCAF Mediates MBD1-Dependent Transcriptional Repression". Mol. Cell. Biol. 23 (8). United States: 2834–43. doi:10.1128/MCB.23.8.2834-2843.2003. ISSN 0270-7306. PMC 152570. PMID 12665582.
- ^ Sin, Jun Hyung; Zuckerman, Cassandra; Cortez, Jessica T.; Eckalbar, Walter L.; Erle, David J.; Anderson, Mark S.; Waterfield, Michael R. (2019-09-02). "The epigenetic regulator ATF7ip inhibits Il2 expression, regulating Th17 responses". The Journal of Experimental Medicine. 216 (9): 2024–2037. doi:10.1084/jem.20182316. ISSN 1540-9538. PMC 6719416. PMID 31217192.
- ^ Zhao, Zhipeng; Feng, Lu; Peng, Xuerun; Ma, Tingnan; Tong, Rongsheng; Zhong, Lei (2022). "Role of histone methyltransferase SETDB1 in regulation of tumourigenesis and immune response". Frontiers in Pharmacology. 13: 1073713. doi:10.3389/fphar.2022.1073713. ISSN 1663-9812. PMC 9793902. PMID 36582533.
{{cite journal}}: CS1 maint: unflagged free DOI (link)
Further reading
- Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
- Yamada K, Kawata H, Shou Z, et al. (2003). "Analysis of zinc-fingers and homeoboxes (ZHX)-1-interacting proteins: molecular cloning and characterization of a member of the ZHX family, ZHX3". Biochem. J. 373 (Pt 1): 167–78. doi:10.1042/BJ20021866. PMC 1223464. PMID 12659632.
- Fujita N, Watanabe S, Ichimura T, et al. (2003). "MCAF Mediates MBD1-Dependent Transcriptional Repression". Mol. Cell. Biol. 23 (8): 2834–43. doi:10.1128/MCB.23.8.2834-2843.2003. PMC 152570. PMID 12665582.
- Morris JA, Kandpal G, Ma L, Austin CP (2004). "DISC1 (Disrupted-In-Schizophrenia 1) is a centrosome-associated protein that interacts with MAP1A, MIPT3, ATF4/5 and NUDEL: regulation and loss of interaction with mutation". Hum. Mol. Genet. 12 (13): 1591–608. doi:10.1093/hmg/ddg162. PMID 12812986.
- Wang H, An W, Cao R, et al. (2003). "mAM facilitates conversion by ESET of dimethyl to trimethyl lysine 9 of histone H3 to cause transcriptional repression". Mol. Cell. 12 (2): 475–87. doi:10.1016/j.molcel.2003.08.007. PMID 14536086.
- Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
- Colland F, Jacq X, Trouplin V, et al. (2004). "Functional Proteomics Mapping of a Human Signaling Pathway". Genome Res. 14 (7): 1324–32. doi:10.1101/gr.2334104. PMC 442148. PMID 15231748.
- Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
- Ichimura T, Watanabe S, Sakamoto Y, et al. (2005). "Transcriptional repression and heterochromatin formation by MBD1 and MCAF/AM family proteins". J. Biol. Chem. 280 (14): 13928–35. doi:10.1074/jbc.M413654200. PMID 15691849.
- Chang LK, Chung JY, Hong YR, et al. (2005). "Activation of Sp1-mediated transcription by Rta of Epstein–Barr virus via an interaction with MCAF1". Nucleic Acids Res. 33 (20): 6528–39. doi:10.1093/nar/gki956. PMC 1298921. PMID 16314315.
- Uchimura Y, Ichimura T, Uwada J, et al. (2006). "Involvement of SUMO modification in MBD1- and MCAF1-mediated heterochromatin formation". J. Biol. Chem. 281 (32): 23180–90. doi:10.1074/jbc.M602280200. PMID 16757475.
{{cite journal}}: CS1 maint: unflagged free DOI (link) - Olsen JV, Blagoev B, Gnad F, et al. (2006). "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks". Cell. 127 (3): 635–48. doi:10.1016/j.cell.2006.09.026. PMID 17081983. S2CID 7827573.
External links
- Human ATF7IP genome location and ATF7IP gene details page in the UCSC Genome Browser.
- PDBe-KB provides an overview of all the structure information available in the PDB for Human Activating transcription factor 7-interacting protein 1 (ATF7IP)
 | This article on a gene on human chromosome 12 is a stub. You can help Wikipedia by expanding it. |