VGT-309: Difference between revisions

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VGT-309 is an experimental "Cathepsin-Targeted Quenched Activity-Based Probe" designed to highlight cancers for fluorescence guided surgery.^[1]^[2]^[3]

References

^ Suurs, Frans V.; Qiu, Si-Qi; Yim, Joshua J.; Schröder, Carolien P.; Timmer-Bosscha, Hetty; Bensen, Eric S.; Santini, John T.; de Vries, Elisabeth G. E.; Bogyo, Matthew; van Dam, Gooitzen M. (29 September 2020). "Fluorescent image-guided surgery in breast cancer by intravenous application of a quenched fluorescence activity-based probe for cysteine cathepsins in a syngeneic mouse model". EJNMMI Research. 10 (1): 111. doi:10.1186/s13550-020-00688-0. ISSN 2191-219X.{{cite journal}}: CS1 maint: unflagged free DOI (link)
^ Santiago, Nicole Lugo; Wen, Wei; Kohut, Adrian; Bensen, Eric; Santini, John; Yim, John; Fong, Yuman; Han, Ernest (1 August 2022). "Preclinical evaluation of a novel cathepsin-activated fluorescent probe VGT-309 for identification of ovarian cancer in a mouse model (248)". Gynecologic Oncology. 166: S134. doi:10.1016/S0090-8258(22)01471-8. ISSN 0090-8258.
^ Kennedy, Gregory T.; Holt, David E.; Azari, Feredun S.; Bernstein, Elizabeth; Nadeem, Bilal; Chang, Ashley; Sullivan, Neil T.; Segil, Alix; Desphande, Charuhas; Bensen, Eric; Santini, John T.; Kucharczuk, John C.; Delikatny, Edward J.; Bogyo, Matthew; Egan, A. J. Matthew; Bradley, Charles W.; Eruslanov, Evgeniy; Lickliter, Jason D.; Wright, Gavin; Singhal, Sunil (1 September 2022). "A Cathepsin-Targeted Quenched Activity-Based Probe Facilitates Enhanced Detection of Human Tumors during Resection". Clinical Cancer Research: An Official Journal of the American Association for Cancer Research. 28 (17): 3729–3741. doi:10.1158/1078-0432.CCR-22-1215. ISSN 1557-3265.

[1] Suurs, Frans V.; Qiu, Si-Qi; Yim, Joshua J.; Schröder, Carolien P.; Timmer-Bosscha, Hetty; Bensen, Eric S.; Santini, John T.; de Vries, Elisabeth G. E.; Bogyo, Matthew; van Dam, Gooitzen M. (29 September 2020). "Fluorescent image-guided surgery in breast cancer by intravenous application of a quenched fluorescence activity-based probe for cysteine cathepsins in a syngeneic mouse model". EJNMMI Research. 10 (1): 111. doi:10.1186/s13550-020-00688-0. ISSN 2191-219X.{{cite journal}}: CS1 maint: unflagged free DOI (link)

[2] Santiago, Nicole Lugo; Wen, Wei; Kohut, Adrian; Bensen, Eric; Santini, John; Yim, John; Fong, Yuman; Han, Ernest (1 August 2022). "Preclinical evaluation of a novel cathepsin-activated fluorescent probe VGT-309 for identification of ovarian cancer in a mouse model (248)". Gynecologic Oncology. 166: S134. doi:10.1016/S0090-8258(22)01471-8. ISSN 0090-8258.

[3] Kennedy, Gregory T.; Holt, David E.; Azari, Feredun S.; Bernstein, Elizabeth; Nadeem, Bilal; Chang, Ashley; Sullivan, Neil T.; Segil, Alix; Desphande, Charuhas; Bensen, Eric; Santini, John T.; Kucharczuk, John C.; Delikatny, Edward J.; Bogyo, Matthew; Egan, A. J. Matthew; Bradley, Charles W.; Eruslanov, Evgeniy; Lickliter, Jason D.; Wright, Gavin; Singhal, Sunil (1 September 2022). "A Cathepsin-Targeted Quenched Activity-Based Probe Facilitates Enhanced Detection of Human Tumors during Resection". Clinical Cancer Research: An Official Journal of the American Association for Cancer Research. 28 (17): 3729–3741. doi:10.1158/1078-0432.CCR-22-1215. ISSN 1557-3265.

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