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He is the co-author of the books:
He is the co-author of the books:


* [https://link.springer.com/book/10.1007/978-1-4939-3103-3 David Holcman and Zeev Schuss, ''Stochastic Narrow Escape in Molecular and Cellular Biology: Analysis and Applications'', 2015-09-08, <nowiki>ISBN 978-1493931026</nowiki>]
* [https://link.springer.com/book/10.1007/978-1-4939-3103-3 David Holcman and Zeev Schuss, ''Stochastic Narrow Escape in Molecular and Cellular Biology: Analysis and Applications'', 2015-09-08,] {{ISBN|978-1-4939-3102-6}}
* [https://link.springer.com/book/10.1007/978-3-319-62627-7 David Holcman (editor), ''Stochastic Processes, Multiscale Modeling, and Numerical Methods for Computational Cellular Biology'', 2017-10-04, ISBN 978-331962626]0
* [https://link.springer.com/book/10.1007/978-3-319-62627-7 David Holcman (editor), ''Stochastic Processes, Multiscale Modeling, and Numerical Methods for Computational Cellular Biology'', 2017-10-04,] {{ISBN|978-3-319-62626-0}}
* [https://link.springer.com/book/10.1007/978-3-319-76895-3 David Holcman and Zeev Schuss, ''Asymptotics of Elliptic and Parabolic PDEs: and their Applications in Statistical Physics, Computational Neuroscience, and Biophysics'', 2018-05-25, <nowiki>ISBN 978-3319768946</nowiki>]
* [https://link.springer.com/book/10.1007/978-3-319-76895-3 David Holcman and Zeev Schuss, ''Asymptotics of Elliptic and Parabolic PDEs: and their Applications in Statistical Physics, Computational Neuroscience, and Biophysics'', 2018-05-25] {{ISBN|978-3-319-76894-6}}


== Awards ==
== Awards ==

Revision as of 06:17, 12 January 2024

David Holcman is an applied mathematician, biophysicist and computational biologist at École Normale Supérieure in Paris. He is known for his work on the narrow escape problem,.[1][2] the redundancy principle in biology[3][4][5] the modeling of molecular trafficking in neurobiology, of diffusion and electrodiffusion in dendritic spines, modeling neuronal network dynamics such as Up and Down states in electrophysiology, developing multiscale methods to analyse large amount of molecular super-resolution trajectories, and developing polymer physics to study the nucleus organization.[6] These approaches led to several verified predictions in the life sciences such as nanocolumn organization of synapses[7][8] and astrocytic protrusion penetrating synapses[9]

Works

His research interests include mathematical biology, data modeling, computational methods, stochastic simulations, theory of cellular microworld, data modeling, neuronal networks, computational biology and neuroscience, asymptotic approaches in partial differential equations, predictive medicine, electroencephalography (EEG) analysis, and modeling organelles in cells.[10] Other contributions concern methods of analyzing single particles trajectories and the development of statistical methods, polymer models, analysis and simulations to study chromatin and nucleus organization.[10]

Publications

Holcman has more than 220 published journal articles and has registered 2 patents.

He is the co-author of the books:

  • David Holcman and Zeev Schuss, Stochastic Narrow Escape in Molecular and Cellular Biology: Analysis and Applications, 2015-09-08, ISBN 978-1-4939-3102-6
  • David Holcman (editor), Stochastic Processes, Multiscale Modeling, and Numerical Methods for Computational Cellular Biology, 2017-10-04, ISBN 978-3-319-62626-0
  • David Holcman and Zeev Schuss, Asymptotics of Elliptic and Parabolic PDEs: and their Applications in Statistical Physics, Computational Neuroscience, and Biophysics, 2018-05-25 ISBN 978-3-319-76894-6

Awards

Holcman has received several awards, including a Sloan-Keck fellowship award (2002) a Marie-Curie Award[11] (2013), and a Simons Fellowship. He is also recipient of 2 ERCs: an ERC Starting Grant[12] in mathematics (2007) and an ERC-Advanced Grant in computational biology[13] (2019).

References

  1. ^ Mangeat, M; Rieger, H (2019-10-18). "The narrow escape problem in a circular domain with radial piecewise constant diffusivity". Journal of Physics A: Mathematical and Theoretical. 52 (42): 424002. arXiv:1906.06975. Bibcode:2019JPhA...52P4002M. doi:10.1088/1751-8121/ab4348. ISSN 1751-8113. S2CID 189928197.
  2. ^ Schuss, Z. (2012-10-01). "The Narrow Escape Problem—A Short Review of Recent Results". Journal of Scientific Computing. 53 (1): 194–210. doi:10.1007/s10915-012-9590-y. ISSN 1573-7691. S2CID 254702232.
  3. ^ Redner, S.; Meerson, B. (2019-03-01). "Redundancy, extreme statistics and geometrical optics of Brownian motion: Comment on "Redundancy principle and the role of extreme statistics in molecular and cellular biology" by Z. Schuss et al". Physics of Life Reviews. 28: 80–82. Bibcode:2019PhLRv..28...80R. doi:10.1016/j.plrev.2019.01.020. ISSN 1571-0645. PMID 30718199. S2CID 73448264.
  4. ^ Sokolov, Igor M. (2019-03-01). "Extreme fluctuation dominance in biology: On the usefulness of wastefulness: Comment on "Redundancy principle and the role of extreme statistics in molecular and cellular biology" by Z. Schuss, K. Basnayake and D. Holcman". Physics of Life Reviews. 28: 88–91. Bibcode:2019PhLRv..28...88S. doi:10.1016/j.plrev.2019.03.003. ISSN 1571-0645. PMID 30904271. S2CID 85496733.
  5. ^ Coombs, Daniel (2019-03-01). "First among equals: Comment on "Redundancy principle and the role of extreme statistics in molecular and cellular biology" by Z. Schuss, K. Basnayake and D. Holcman". Physics of Life Reviews. 28: 92–93. Bibcode:2019PhLRv..28...92C. doi:10.1016/j.plrev.2019.03.002. ISSN 1571-0645. PMID 30905554. S2CID 85497459.
  6. ^ Blythe, Richard A.; MacPhee, Cait E. (2013-11-27). "The Life and Death of Cells". Physics. 6 (22): 129. doi:10.1103/PhysRevLett.111.228104. PMID 24329474.
  7. ^ Guzikowski, Natalie J.; Kavalali, Ege T. (2021). "Nano-Organization at the Synapse: Segregation of Distinct Forms of Neurotransmission". Frontiers in Synaptic Neuroscience. 13: 796498. doi:10.3389/fnsyn.2021.796498. ISSN 1663-3563. PMC 8727373. PMID 35002671.
  8. ^ Tang, Ai-Hui; Chen, Haiwen; Li, Tuo P.; Metzbower, Sarah R.; MacGillavry, Harold D.; Blanpied, Thomas A. (August 2016). "A trans-synaptic nanocolumn aligns neurotransmitter release to receptors". Nature. 536 (7615): 210–214. Bibcode:2016Natur.536..210T. doi:10.1038/nature19058. ISSN 1476-4687. PMC 5002394. PMID 27462810.
  9. ^ Welberg, Leonie (April 2014). "Invasion of the astrocytes!". Nature Reviews Neuroscience. 15 (4): 207. doi:10.1038/nrn3720. ISSN 1471-0048. PMID 24619346. S2CID 13189654.
  10. ^ a b "David Holcman". scholar.google.com. Retrieved 2023-09-14.
  11. ^ "Home | Marie Skłodowska-Curie Actions". marie-sklodowska-curie-actions.ec.europa.eu. Retrieved 2023-03-22.
  12. ^ "David Holcman | INSB". www.insb.cnrs.fr (in French). 31 July 2007. Retrieved 2023-03-22.
  13. ^ "David Holcman, lauréat ERC Advanced Grants | ENS". www.ens.psl.eu. Retrieved 2023-03-22.
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