MMP9: Difference between revisions
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PBB Automatic Update: Updated Protein Box, Updated Summary, and Updated Citations. |
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| image_source = [[Protein_Data_Bank|PDB]] rendering based on 1itv. |
| image_source = [[Protein_Data_Bank|PDB]] rendering based on 1itv. |
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| PDB = {{PDB2|1itv}}, {{PDB2|1l6j}} |
| PDB = {{PDB2|1itv}}, {{PDB2|1l6j}} |
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| Name = |
| Name = Matrix metallopeptidase 9 (gelatinase B, 92kDa gelatinase, 92kDa type IV collagenase) |
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| HGNCid = 7176 |
| HGNCid = 7176 |
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| Symbol = MMP9 |
| Symbol = MMP9 |
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| Homologene = 3659 |
| Homologene = 3659 |
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| MGIid = 97011 |
| MGIid = 97011 |
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| GeneAtlas_image1 = PBB_GE_MMP9_203936_s_at.png |
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| GeneAtlas_image = |
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| DateOfBotUpdate = |
| DateOfBotUpdate = 21:19, 10 September 2007 (UTC) |
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| Function = {{GNF_GO|id=GO: |
| Function = {{GNF_GO|id=GO:0004229 |text = gelatinase B activity}} {{GNF_GO|id=GO:0005509 |text = calcium ion binding}} {{GNF_GO|id=GO:0005518 |text = collagen binding}} {{GNF_GO|id=GO:0008133 |text = collagenase activity}} {{GNF_GO|id=GO:0008270 |text = zinc ion binding}} |
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| Component = {{GNF_GO|id=GO:0005578 |text = proteinaceous extracellular matrix}} {{GNF_GO|id=GO:0005615 |text = extracellular space}} |
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| Process = {{GNF_GO|id=GO:0000270 |text = peptidoglycan metabolic process}} {{GNF_GO|id=GO:0001501 |text = skeletal development}} {{GNF_GO|id=GO:0006508 |text = proteolysis}} {{GNF_GO|id=GO:0030198 |text = extracellular matrix organization and biogenesis}} {{GNF_GO|id=GO:0030225 |text = macrophage differentiation}} {{GNF_GO|id=GO:0030574 |text = collagen catabolic process}} {{GNF_GO|id=GO:0043065 |text = positive regulation of apoptosis}} |
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| Orthologs = {{GNF_Ortholog_box |
| Orthologs = {{GNF_Ortholog_box |
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| Hs_EntrezGene = 4318 |
| Hs_EntrezGene = 4318 |
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| Mm_GenLoc_start = 164639437 |
| Mm_GenLoc_start = 164639437 |
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| Mm_GenLoc_end = 164647050 |
| Mm_GenLoc_end = 164647050 |
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| Mm_Uniprot = |
| Mm_Uniprot = Q2M4J5 |
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}} |
}} |
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}} |
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{{PBB_Summary |
{{PBB_Summary |
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| section_title = |
| section_title = |
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| summary_text = Proteins of the matrix metalloproteinase (MMP) family are involved in the breakdown of extracellular matrix in normal physiological processes, such as embryonic development, reproduction, and tissue remodeling, as well as in disease processes, such as arthritis and metastasis. Most MMP's are secreted as inactive proproteins which are activated when cleaved by extracellular proteinases. The enzyme encoded by this gene degrades type IV and V collagens. Studies in rhesus monkeys suggest that the enzyme is involved in IL-8-induced mobilization of hematopoietic progenitor cells from bone marrow, and murine studies suggest a role in tumor-associated tissue remodeling. |
| summary_text = Proteins of the matrix metalloproteinase (MMP) family are involved in the breakdown of extracellular matrix in normal physiological processes, such as embryonic development, reproduction, and tissue remodeling, as well as in disease processes, such as arthritis and metastasis. Most MMP's are secreted as inactive proproteins which are activated when cleaved by extracellular proteinases. The enzyme encoded by this gene degrades type IV and V collagens. Studies in rhesus monkeys suggest that the enzyme is involved in IL-8-induced mobilization of hematopoietic progenitor cells from bone marrow, and murine studies suggest a role in tumor-associated tissue remodeling.<ref>{{cite web | title = Entrez Gene: MMP9 matrix metallopeptidase 9 (gelatinase B, 92kDa gelatinase, 92kDa type IV collagenase)| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=4318| accessdate = 2007-09-05}}</ref> |
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{{PBB_Further_reading |
{{PBB_Further_reading |
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| citations = |
| citations = |
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*{{cite journal | author=Nagase H, Woessner JF |title=Matrix metalloproteinases. |journal=J. Biol. Chem. |volume=274 |issue= 31 |pages= 21491-4 |year= 1999 |pmid= 10419448 |doi= }} |
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*{{cite journal | author=Starckx S, Van den Steen PE, Wuyts A, ''et al.'' |title=Neutrophil gelatinase B and chemokines in leukocytosis and stem cell mobilization. |journal=Leuk. Lymphoma |volume=43 |issue= 2 |pages= 233-41 |year= 2003 |pmid= 11999552 |doi= }} |
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*{{cite journal | author=Bischof P, Meisser A, Campana A |title=Control of MMP-9 expression at the maternal-fetal interface. |journal=J. Reprod. Immunol. |volume=55 |issue= 1-2 |pages= 3-10 |year= 2002 |pmid= 12062817 |doi= }} |
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*{{cite journal | author=St-Pierre Y, Van Themsche C, Estève PO |title=Emerging features in the regulation of MMP-9 gene expression for the development of novel molecular targets and therapeutic strategies. |journal=Current drug targets. Inflammation and allergy |volume=2 |issue= 3 |pages= 206-15 |year= 2003 |pmid= 14561155 |doi= }} |
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*{{cite journal | author=Lee JM, Yin K, Hsin I, ''et al.'' |title=Matrix metalloproteinase-9 in cerebral-amyloid-angiopathy-related hemorrhage. |journal=J. Neurol. Sci. |volume=229-230 |issue= |pages= 249-54 |year= 2005 |pmid= 15760647 |doi= 10.1016/j.jns.2004.11.041 }} |
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*{{cite journal | author=Nair RR, Boyd DD |title=Expression cloning of novel regulators of 92 kDa type IV collagenase expression. |journal=Biochem. Soc. Trans. |volume=33 |issue= Pt 5 |pages= 1135-6 |year= 2006 |pmid= 16246065 |doi= 10.1042/BST20051135 }} |
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*{{cite journal | author=Ram M, Sherer Y, Shoenfeld Y |title=Matrix metalloproteinase-9 and autoimmune diseases. |journal=J. Clin. Immunol. |volume=26 |issue= 4 |pages= 299-307 |year= 2006 |pmid= 16652230 |doi= 10.1007/s10875-006-9022-6 }} |
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{{refend}} |
{{refend}} |
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Revision as of 21:19, 10 September 2007
Matrix metallopeptidase 9 (gelatinase B, 92kDa gelatinase, 92kDa type IV collagenase), also known as MMP9, is a human gene.
References
- ^ a b c GRCh38: Ensembl release 89: ENSG00000100985 – Ensembl, May 2017
- ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000017737 – Ensembl, May 2017
- ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
- ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.