LRRK2

LRRK2
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 2ZEJ, 3D6T
Identifiers
Aliases	LRRK2, AURA17, DARDARIN, PARK8, RIPK7, ROCO2, leucine-rich repeat kinase 2, leucine rich repeat kinase 2
External IDs	OMIM: 609007 MGI: 1913975 HomoloGene: 18982 GeneCards: LRRK2
EC number	2.7.11.1
Gene location (Human) Chr. Chromosome 12 (human) Band 12q12 Start 40,196,744 bp End 40,369,285 bp
Gene location (Mouse) Chr. Chromosome 15 (mouse) Band 15|15 E3 Start 91,557,378 bp End 91,700,323 bp
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in monocyte lower lobe of lung blood upper lobe of lung upper lobe of left lung right lung Achilles tendon visceral pleura trabecular bone bone marrow cells Top expressed in kidney proximal tubule left lung left lung lobe superior frontal gyrus spleen right lung olfactory tubercle right lung lobe lymph node More reference expression data BioGPS More reference expression data
Gene ontology Molecular function protein homodimerization activity signaling receptor complex adaptor activity clathrin binding co-receptor binding transferase activity GTPase activator activity protein kinase activity protein kinase A binding peroxidase inhibitor activity SNARE binding nucleotide binding identical protein binding GTPase activity syntaxin-1 binding protein serine/threonine kinase activity tubulin binding transmembrane transporter binding microtubule binding MAP kinase kinase activity GTP binding ATP binding GTP-dependent protein kinase activity beta-catenin destruction complex binding protein binding kinase activity actin binding magnesium ion binding Cellular component cytoplasmic vesicle endosome extracellular exosome Wnt signalosome neuronal cell body trans-Golgi network mitochondrial membranes synapse cytoplasm mitochondrial outer membrane synaptic vesicle membrane perikaryon endoplasmic reticulum plasma membrane microvillus mitochondrial matrix dendrite cytoplasm growth cone cell projection dendrite lysosome neuron projection Golgi-associated vesicle mitochondrion mitochondrial inner membrane autolysosome terminal bouton intracellular anatomical structure membrane membrane raft axon amphisome multivesicular body, internal vesicle synaptic vesicle inclusion body cell junction cytoplasmic side of mitochondrial outer membrane cytosol Golgi apparatus postsynapse extracellular space nucleus intracellular membrane-bounded organelle caveola neck endoplasmic reticulum exit site glutamatergic synapse presynaptic cytosol ribonucleoprotein complex Biological process lysosome organization response to oxidative stress cellular response to dopamine regulation of autophagy positive regulation of autophagy positive regulation of dopamine receptor signaling pathway regulation of neuroblast proliferation intracellular distribution of mitochondria negative regulation of protein processing negative regulation of protein processing involved in protein targeting to mitochondrion protein localization to mitochondrion positive regulation of canonical Wnt signaling pathway autophagy neuromuscular junction development phosphorylation positive regulation of protein binding regulation of branching morphogenesis of a nerve mitochondrion localization positive regulation of protein autoubiquitination regulation of synaptic vesicle transport positive regulation of protein phosphorylation regulation of kidney size regulation of synaptic vesicle exocytosis positive regulation of MAP kinase activity peptidyl-threonine phosphorylation MAPK cascade Wnt signalosome assembly protein phosphorylation regulation of synaptic transmission, glutamatergic excitatory postsynaptic potential negative regulation of hydrogen peroxide-induced cell death regulation of dopamine receptor signaling pathway regulation of membrane potential protein autophosphorylation regulation of mitochondrial fission regulation of neuron maturation reactive oxygen species metabolic process positive regulation of programmed cell death regulation of neuron death regulation of mitochondrial depolarization cellular response to oxidative stress negative regulation of late endosome to lysosome transport intracellular signal transduction regulation of lysosomal lumen pH negative regulation of GTPase activity locomotory exploration behavior Golgi organization canonical Wnt signaling pathway neuron projection morphogenesis positive regulation of protein ubiquitination regulation of canonical Wnt signaling pathway exploration behavior cellular response to organic cyclic compound tangential migration from the subventricular zone to the olfactory bulb regulation of protein kinase A signaling calcium-mediated signaling negative regulation of thioredoxin peroxidase activity by peptidyl-threonine phosphorylation negative regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway positive regulation of proteasomal ubiquitin-dependent protein catabolic process negative regulation of neuron death negative regulation of protein targeting to mitochondrion peptidyl-serine phosphorylation determination of adult lifespan negative regulation of excitatory postsynaptic potential negative regulation of protein phosphorylation neuron death GTP metabolic process negative regulation of autophagosome assembly olfactory bulb development cellular response to starvation regulation of dendritic spine morphogenesis cell differentiation endocytosis negative regulation of protein binding mitochondrion organization cellular response to manganese ion negative regulation of macroautophagy regulation of locomotion positive regulation of GTPase activity regulation of retrograde transport, endosome to Golgi regulation of CAMKK-AMPK signaling cascade positive regulation of histone deacetylase activity endoplasmic reticulum organization spermatogenesis regulation of gene expression negative regulation of neuron projection development striatum development regulation of protein stability positive regulation of nitric-oxide synthase biosynthetic process regulation of ER to Golgi vesicle-mediated transport protein localization to endoplasmic reticulum exit site neuron projection arborization regulation of synaptic vesicle endocytosis positive regulation of synaptic vesicle endocytosis positive regulation of microglial cell activation protein import into nucleus Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 120892 66725 Ensembl ENSG00000188906 ENSMUSG00000036273 UniProt Q5S007 Q5S006 RefSeq (mRNA) NM_198578 NM_025730 RefSeq (protein) NP_940980 NP_080006 Location (UCSC) Chr 12: 40.2 – 40.37 Mb Chr 15: 91.56 – 91.7 Mb PubMed search
Wikidata
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LRRK2 is a protein member of the leucine-rich repeat kinase family.

The LRRK2 gene encodes a protein with an ankyrin repeat region, a leucine-rich repeat (LRR) domain, a kinase domain, a DFG-like motif, a RAS domain, a GTPase domain, a MLK-like domain, and a WD40 domain. The protein is present largely in the cytoplasm but also associates with the mitochondrial outer membrane. Mutations in this gene have been associated with Parkinson's disease type 8.

External links

• LRRK2+protein,+human at the U.S. National Library of Medicine Medical Subject Headings (MeSH)