ADAM10

ADAM10
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 1M1I
Identifiers
Aliases	ADAM10, AD10, AD18, CD156c, HsT18717, MADM, RAK, kuz, CDw156, ADAM metallopeptidase domain 10
External IDs	OMIM: 602192; MGI: 109548; HomoloGene: 865; GeneCards: ADAM10; OMA:ADAM10 - orthologs
Gene location (Human) Chr. Chromosome 15 (human) Band 15q21.3 Start 58,588,809 bp End 58,749,791 bp
Gene location (Mouse) Chr. Chromosome 9 (mouse) Band 9 D|9 39.53 cM Start 70,586,279 bp End 70,687,511 bp
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in stromal cell of endometrium amniotic fluid visceral pleura trigeminal ganglion monocyte oocyte olfactory bulb placenta epithelium of colon bone marrow cells Top expressed in cumulus cell atrioventricular valve decidua atrium mucous cell of stomach Gonadal ridge molar left lung lobe urothelium iris More reference expression data BioGPS More reference expression data
Gene ontology Molecular function protein homodimerization activity SH3 domain binding endopeptidase activity metal ion binding integrin binding peptidase activity protein binding signaling receptor binding hydrolase activity protein kinase binding metallopeptidase activity metalloendopeptidase activity Cellular component cytoplasm integral component of membrane membrane postsynaptic density focal adhesion plasma membrane perinuclear endoplasmic reticulum Golgi-associated vesicle tetraspanin-enriched microdomain extracellular exosome nucleus cell surface Golgi membrane extracellular space Golgi apparatus specific granule membrane tertiary granule membrane endoplasmic reticulum lumen trans-Golgi network synaptic vesicle dendrite neuronal cell body dendritic spine postsynaptic membrane postsynapse glutamatergic synapse Biological process Notch signaling pathway positive regulation of cell migration ephrin receptor signaling pathway cell-cell signaling constitutive protein ectodomain proteolysis protein processing extracellular matrix disassembly in utero embryonic development proteolysis monocyte activation response to tumor necrosis factor protein phosphorylation positive regulation of cell growth positive regulation of T cell chemotaxis positive regulation of cell population proliferation Notch receptor processing integrin-mediated signaling pathway membrane protein ectodomain proteolysis negative regulation of cell adhesion neutrophil degranulation post-translational protein modification spermatogenesis amyloid-beta formation Notch receptor processing, ligand-dependent positive regulation of apoptotic process regulation of dendritic spine morphogenesis response to antineoplastic agent regulation of neurotransmitter receptor localization to postsynaptic specialization membrane postsynapse organization Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 102 11487 Ensembl ENSG00000137845 ENSMUSG00000054693 UniProt O14672 O35598 RefSeq (mRNA) NM_001110 NM_001320570 NM_007399 RefSeq (protein) NP_001101 NP_001307499 NP_001101.1 NP_031425 Location (UCSC) Chr 15: 58.59 – 58.75 Mb Chr 9: 70.59 – 70.69 Mb PubMed search
Wikidata
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ADAM metallopeptidase domain 10, also known as ADAM10, is a human gene.