SOCS2

SOCS2
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 2C9W, 4JGH, 5BO4
Identifiers
Aliases	SOCS2, CIS2, Cish2, SOCS-2, SSI-2, SSI2, STATI2, suppressor of cytokine signaling 2
External IDs	OMIM: 605117 MGI: 1201787 HomoloGene: 2880 GeneCards: SOCS2
Gene location (Human) Chr. Chromosome 12 (human) Band 12q22 Start 93,569,814 bp End 93,583,487 bp
Gene location (Mouse) Chr. Chromosome 10 (mouse) Band 10 C2|10 49.35 cM Start 95,221,224 bp End 95,253,042 bp
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in secondary oocyte canal of the cervix vena cava myometrium seminal vesicula prostate pituitary gland left uterine tube anterior pituitary mucosa of urinary bladder Top expressed in cumulus cell olfactory epithelium left lung lobe stria vascularis right lung interventricular septum right lung lobe superior surface of tongue myocardium of ventricle parotid gland More reference expression data BioGPS More reference expression data
Gene ontology Molecular function insulin-like growth factor receptor binding protein kinase inhibitor activity JAK pathway signal transduction adaptor activity protein binding growth hormone receptor binding 1-phosphatidylinositol-3-kinase regulator activity Cellular component cytoplasm cytosol phosphatidylinositol 3-kinase complex Biological process receptor signaling pathway via JAK-STAT response to estradiol intracellular signal transduction negative regulation of protein kinase activity cytokine-mediated signaling pathway negative regulation of apoptotic process negative regulation of insulin receptor signaling pathway cellular response to hormone stimulus growth hormone receptor signaling pathway regulation of signal transduction regulation of cell growth protein ubiquitination regulation of growth negative regulation of signal transduction negative regulation of receptor signaling pathway via JAK-STAT positive regulation of signal transduction lactation regulation of multicellular organism growth negative regulation of multicellular organism growth post-translational protein modification positive regulation of neuron differentiation mammary gland alveolus development interleukin-7-mediated signaling pathway regulation of phosphatidylinositol 3-kinase activity phosphatidylinositol phosphate biosynthetic process Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 8835 216233 Ensembl ENSG00000120833 ENSMUSG00000020027 UniProt O14508 O35717 RefSeq (mRNA) NM_001270467 NM_001270468 NM_001270469 NM_001270470 NM_001270471 NM_003877 NM_001168655 NM_001168656 NM_001168657 NM_007706 RefSeq (protein) NP_001257396 NP_001257397 NP_001257398 NP_001257399 NP_001257400 NP_003868 NP_001162126 NP_001162127 NP_001162128 NP_031732 Location (UCSC) Chr 12: 93.57 – 93.58 Mb Chr 10: 95.22 – 95.25 Mb PubMed search
Wikidata
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Suppressor of cytokine signaling 2, also known as SOCS2, is a human gene.