PIK3C2G

PIK3C2G
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 2WWE
Identifiers
Aliases	PIK3C2G, PI3K-C2-gamma, PI3K-C2GAMMA, phosphatidylinositol-4-phosphate 3-kinase catalytic subunit type 2 gamma
External IDs	OMIM: 609001 MGI: 1203730 HomoloGene: 3362 GeneCards: PIK3C2G
Gene location (Human) Chr. Chromosome 12 (human) Band 12p12.3 Start 18,242,961 bp End 18,648,416 bp
Gene location (Mouse) Chr. Chromosome 6 (mouse) Band 6 G2|6 69.7 cM Start 139,564,219 bp End 139,915,010 bp
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in corpus epididymis hair follicle skin of abdomen right lobe of liver gallbladder stomach body of stomach seminal vesicula pylorus vulva Top expressed in stomach epithelium of stomach morula outer nuclear layer proximal tubule spermatid liver lip cumulus cell inner nuclear layer More reference expression data BioGPS More reference expression data
Gene ontology Molecular function nucleotide binding transferase activity kinase activity phosphatidylinositol phosphate kinase activity phosphatidylinositol binding 1-phosphatidylinositol-3-kinase activity ATP binding 1-phosphatidylinositol-4-phosphate 3-kinase activity phosphatidylinositol 3-kinase activity Cellular component cytosol membrane plasma membrane phosphatidylinositol 3-kinase complex cytoplasm Biological process phosphatidylinositol-mediated signaling phosphatidylinositol phosphate biosynthetic process chemotaxis phosphorylation phosphatidylinositol-3-phosphate biosynthetic process phosphatidylinositol 3-kinase signaling cell migration phosphatidylinositol biosynthetic process Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 5288 18705 Ensembl ENSG00000139144 ENSMUSG00000030228 UniProt O75747 O70167 RefSeq (mRNA) NM_001288772 NM_001288774 NM_004570 NM_011084 NM_207683 RefSeq (protein) NP_001275701 NP_001275703 NP_004561 NP_035214 NP_997566 Location (UCSC) Chr 12: 18.24 – 18.65 Mb Chr 6: 139.56 – 139.92 Mb PubMed search
Wikidata
View/Edit Human View/Edit Mouse

Phosphoinositide-3-kinase, class 2, gamma polypeptide, also known as PIK3C2G, is a human gene.

Further reading

{{PBB_Further_reading | citations =

• Lee C, Liu QH, Tomkowicz B; et al. (2004). "Macrophage activation through CCR5- and CXCR4-mediated gp120-elicited signaling pathways". J. Leukoc. Biol. 74 (5): 676–82. doi:10.1189/jlb.0503206. PMID 12960231. {{cite journal}}: Explicit use of et al. in: |author= (help)CS1 maint: multiple names: authors list (link)
• Milani D, Mazzoni M, Borgatti P; et al. (1996). "Extracellular human immunodeficiency virus type-1 Tat protein activates phosphatidylinositol 3-kinase in PC12 neuronal cells". J. Biol. Chem. 271 (38): 22961–4. PMID 8798481. {{cite journal}}: Explicit use of et al. in: |author= (help)CS1 maint: multiple names: authors list (link)
• Mazerolles F, Barbat C, Fischer A (1997). "Down-regulation of LFA-1-mediated T cell adhesion induced by the HIV envelope glycoprotein gp160 requires phosphatidylinositol-3-kinase activity". Eur. J. Immunol. 27 (9): 2457–65. PMID 9341793.{{cite journal}}: CS1 maint: multiple names: authors list (link)
• Borgatti P, Zauli G, Colamussi ML; et al. (1998). "Extracellular HIV-1 Tat protein activates phosphatidylinositol 3- and Akt/PKB kinases in CD4+ T lymphoblastoid Jurkat cells". Eur. J. Immunol. 27 (11): 2805–11. PMID 9394803. {{cite journal}}: Explicit use of et al. in: |author= (help)CS1 maint: multiple names: authors list (link)
• Borgatti P, Zauli G, Cantley LC, Capitani S (1998). "Extracellular HIV-1 Tat protein induces a rapid and selective activation of protein kinase C (PKC)-alpha, and -epsilon and -zeta isoforms in PC12 cells". Biochem. Biophys. Res. Commun. 242 (2): 332–7. PMID 9446795.{{cite journal}}: CS1 maint: multiple names: authors list (link)
• Misawa H, Ohtsubo M, Copeland NG; et al. (1998). "Cloning and characterization of a novel class II phosphoinositide 3-kinase containing C2 domain". Biochem. Biophys. Res. Commun. 244 (2): 531–9. doi:10.1006/bbrc.1998.8294. PMID 9514948. {{cite journal}}: Explicit use of et al. in: |author= (help)CS1 maint: multiple names: authors list (link)
• Ono F, Nakagawa T, Saito S; et al. (1998). "A novel class II phosphoinositide 3-kinase predominantly expressed in the liver and its enhanced expression during liver regeneration". J. Biol. Chem. 273 (13): 7731–6. PMID 9516481. {{cite journal}}: Explicit use of et al. in: |author= (help)CS1 maint: multiple names: authors list (link)
• Milani D, Mazzoni M, Zauli G; et al. (1998). "HIV-1 Tat induces tyrosine phosphorylation of p125FAK and its association with phosphoinositide 3-kinase in PC12 cells". AIDS. 12 (11): 1275–84. PMID 9708406. {{cite journal}}: Explicit use of et al. in: |author= (help)CS1 maint: multiple names: authors list (link)
• Jauliac S, Mazerolles F, Jabado N; et al. (1998). "Ligands of CD4 inhibit the association of phospholipase Cgamma1 with phosphoinositide 3 kinase in T cells: regulation of this association by the phosphoinositide 3 kinase activity". Eur. J. Immunol. 28 (10): 3183–91. PMID 9808187. {{cite journal}}: Explicit use of et al. in: |author= (help)CS1 maint: multiple names: authors list (link)
• Rozycka M, Lu YJ, Brown RA; et al. (1999). "cDNA cloning of a third human C2-domain-containing class II phosphoinositide 3-kinase, PI3K-C2gamma, and chromosomal assignment of this gene (PIK3C2G) to 12p12". Genomics. 54 (3): 569–74. doi:10.1006/geno.1998.5621. PMID 9878262. {{cite journal}}: Explicit use of et al. in: |author= (help)CS1 maint: multiple names: authors list (link)
• Park IW, Wang JF, Groopman JE (2001). "HIV-1 Tat promotes monocyte chemoattractant protein-1 secretion followed by transmigration of monocytes". Blood. 97 (2): 352–8. PMID 11154208.{{cite journal}}: CS1 maint: multiple names: authors list (link)
• Zauli G, Milani D, Mirandola P; et al. (2001). "HIV-1 Tat protein down-regulates CREB transcription factor expression in PC12 neuronal cells through a phosphatidylinositol 3-kinase/AKT/cyclic nucleoside phosphodiesterase pathway". FASEB J. 15 (2): 483–91. doi:10.1096/fj.00-0354com. PMID 11156964. {{cite journal}}: Explicit use of et al. in: |author= (help)CS1 maint: multiple names: authors list (link) CS1 maint: unflagged free DOI (link)
• Deregibus MC, Cantaluppi V, Doublier S; et al. (2002). "HIV-1-Tat protein activates phosphatidylinositol 3-kinase/ AKT-dependent survival pathways in Kaposi's sarcoma cells". J. Biol. Chem. 277 (28): 25195–202. doi:10.1074/jbc.M200921200. PMID 11994280. {{cite journal}}: Explicit use of et al. in: |author= (help)CS1 maint: multiple names: authors list (link) CS1 maint: unflagged free DOI (link)
• Cook JA, August A, Henderson AJ (2002). "Recruitment of phosphatidylinositol 3-kinase to CD28 inhibits HIV transcription by a Tat-dependent mechanism". J. Immunol. 169 (1): 254–60. PMID 12077252.{{cite journal}}: CS1 maint: multiple names: authors list (link)
• François F, Klotman ME (2003). "Phosphatidylinositol 3-kinase regulates human immunodeficiency virus type 1 replication following viral entry in primary CD4+ T lymphocytes and macrophages". J. Virol. 77 (4): 2539–49. PMID 12551992.
• Khan NA, Di Cello F, Nath A, Kim KS (2004). "Human immunodeficiency virus type 1 tat-mediated cytotoxicity of human brain microvascular endothelial cells". J. Neurovirol. 9 (6): 584–93. PMID 14602571.{{cite journal}}: CS1 maint: multiple names: authors list (link)
• Langford D, Hurford R, Hashimoto M; et al. (2006). "Signalling crosstalk in FGF2-mediated protection of endothelial cells from HIV-gp120". BMC neuroscience. 6 (1): 8. doi:10.1186/1471-2202-6-8. PMID 15689238. {{cite journal}}: Explicit use of et al. in: |author= (help)CS1 maint: multiple names: authors list (link) CS1 maint: unflagged free DOI (link)
• {{cite journal | author=Lee C, Tomkowicz B, Freedman BD, Collman RG |title=HIV-1 gp120-induced TNF-{alpha} production by primary human macrophages is mediated by phosphatidylinositol-3 (PI-3) kinase and mitogen-activated protein (MAP) kinase pathways. |journal=J. Leukoc. Biol. |volume=78 |issue= 4 |pages= 1016-23 |year= 2006 |pmid= 16081599 |doi= 10.1189/jlb.0105056 }}
• Anand AR, Ganju RK (2006). "HIV-1 gp120-mediated apoptosis of T cells is regulated by the membrane tyrosine phosphatase CD45". J. Biol. Chem. 281 (18): 12289–99. doi:10.1074/jbc.M511786200. PMID 16524887.{{cite journal}}: CS1 maint: unflagged free DOI (link)

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