Drug intolerance: Difference between revisions
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==Analgesic intolerance== |
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Intolerance to [[analgesic]]s, particularly [[NSAID]]s, is relatively common. Its cause is believed to be variation in the metabolism of [[arachidonic acid]]. Symptoms include chronic [[rhinosinusitis]] with [[nasal polyp]]s, [[asthma]], [[Peptic ulcer|gastrointestinal ulcer]]s, [[angioedema]], and [[urticaria]].<ref name="pmid18389300">{{cite journal |
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| author = Förster U, Olze H |
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| title = [Analgesic intolerance (AI). Key position of ENT physicians for early detection of this condition] |
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| language = German |
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| journal = HNO |
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| volume = 56 |
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| issue = 4 |
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| pages = 443–50; quiz 451 |
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| year = 2008 |
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| month = April |
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| pmid = 18389300 |
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| doi = 10.1007/s00106-008-1701-6 |
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Revision as of 22:32, 6 May 2008
Drug intolerance or drug sensitivity is a lower threshold to the normal pharmacologic action of a drug. It is not to be confused with drug allergy. Drug intolerance is uncommon and idiopathic, thus extremely difficult to predict except in persons with a prior history or a family history of intolerance to that specific drug. Some drug intolerances are known to result from genetic variants of drug metabolism.
Examples
- Tinnitus after a normal dose of aspirin
- Liver failure (possibly also kidney failure) after a normal dose of acetaminophen
- Fatal poisoning in a breastfed newborn baby due to normal use of codeine by the mother[1]
Analgesic intolerance
Intolerance to analgesics, particularly NSAIDs, is relatively common. Its cause is believed to be variation in the metabolism of arachidonic acid. Symptoms include chronic rhinosinusitis with nasal polyps, asthma, gastrointestinal ulcers, angioedema, and urticaria.[2]
See also
References
- ^ Madadi P, Koren G, Cairns J; et al. (2007). "Safety of codeine during breastfeeding: fatal morphine poisoning in the breastfed neonate of a mother prescribed codeine". Can Fam Physician. 53 (1): 33–5. PMID 17872605.
{{cite journal}}: Explicit use of et al. in:|author=(help); Unknown parameter|month=ignored (help)CS1 maint: multiple names: authors list (link) - ^ Förster U, Olze H (2008). "[Analgesic intolerance (AI). Key position of ENT physicians for early detection of this condition]". HNO (in German). 56 (4): 443–50, quiz 451. doi:10.1007/s00106-008-1701-6. PMID 18389300.
{{cite journal}}: Unknown parameter|month=ignored (help)
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