Antibody mimetic: Difference between revisions

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|[[Affibody molecule]]s<ref name="pmid18435759">{{cite journal |author=Nygren PA |title=Alternative binding proteins: affibody binding proteins developed from a small three-helix bundle scaffold |journal=FEBS J. |volume=275 |issue=11 |pages=2668–76 |year=2008 |month=June |pmid=18435759 |doi=10.1111/j.1742-4658.2008.06438.x |url=http://dx.doi.org/10.1111/j.1742-4658.2008.06438.x}}</ref> ||[[Protein A]], Z domain || align="right" | 6 kDa
|[[Affibody molecule]]s<ref name="pmid18435759">{{cite journal |author=Nygren PA |title=Alternative binding proteins: affibody binding proteins developed from a small three-helix bundle scaffold |journal=FEBS J. |volume=275 |issue=11 |pages=2668–76 |year=2008 |month=June |pmid=18435759 |doi=10.1111/j.1742-4658.2008.06438.x |url=http://dx.doi.org/10.1111/j.1742-4658.2008.06438.x}}</ref> ||[[Protein A]], Z domain || align="right" | 6 kDa
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| rowspan="2" | [[Affilin]]s<ref>{{cite journal |author=Ebersbach H, Fiedler E, Scheuermann T, ''et al.'' |title=Affilin-novel binding molecules based on human gamma-B-crystallin, an all beta-sheet protein |journal=J. Mol. Biol. |volume=372 |issue=1 |pages=172–85 |year=2007 |month=September |pmid=17628592 |doi=10.1016/j.jmb.2007.06.045 |url=}}</ref>
| [[Ubiquitin]] || align="right" | 10 kDa
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| γ-B-[[crystallin]] || align="right" | 20 kDa
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|[[Affitin]]s<ref name="pmid18822295">{{cite journal |author=Krehenbrink M, Chami M, Guilvout I, Alzari PM, Pécorari F, Pugsley AP |title=Artificial binding proteins (Affitins) as probes for conformational changes in secretin PulD |journal=J. Mol. Biol. |volume=383 |issue=5 |pages=1058–68 |year=2008 |month=November |pmid=18822295 |doi=10.1016/j.jmb.2008.09.016 |url=http://linkinghub.elsevier.com/retrieve/pii/S0022-2836(08)01117-0}}</ref> ||[[Sac7d]] (from ''[[Sulfolobus]] acidocaldarius'') || align="right" | 7 kDa
|[[Affitin]]s<ref name="pmid18822295">{{cite journal |author=Krehenbrink M, Chami M, Guilvout I, Alzari PM, Pécorari F, Pugsley AP |title=Artificial binding proteins (Affitins) as probes for conformational changes in secretin PulD |journal=J. Mol. Biol. |volume=383 |issue=5 |pages=1058–68 |year=2008 |month=November |pmid=18822295 |doi=10.1016/j.jmb.2008.09.016 |url=http://linkinghub.elsevier.com/retrieve/pii/S0022-2836(08)01117-0}}</ref> ||[[Sac7d]] (from ''[[Sulfolobus]] acidocaldarius'') || align="right" | 7 kDa

Revision as of 20:04, 14 July 2010

Antibody mimetics are organic compounds that, like antibodies, can specifically bind antigens, but that are not structurally related to antibodies. They are usually artificial peptides or proteins with a molar mass of about 3 to 20 kDa, but nucleic acids and small molecules are sometimes considered antibody mimetics as well.[1]

Examples

Antibody mimetic Framework Molar mass
Affibody molecules[2] Protein A, Z domain 6 kDa
Affilins[3] Ubiquitin 10 kDa
γ-B-crystallin 20 kDa
Affitins[4] Sac7d (from Sulfolobus acidocaldarius) 7 kDa
Anticalins[5] Lipocalins 20 kDa
Avimers[6] A domains 9–18 kDa
DARPins[7] Ankyrin repeat motif 12–19 kDa
Fynomers[8] Fyn, SH3 domain 7 kDa
Kunitz domain peptides[9] Various protease inhibitors 6 kDa
Monobodies[10] Fibronectin, 10th type III domain 10 kDa

References

  1. ^ Gebauer M, Skerra A (2009). "Engineered protein scaffolds as next-generation antibody therapeutics". Curr Opin Chem Biol. doi:10.1016/j.cbpa.2009.04.627. PMID 19501012. {{cite journal}}: Unknown parameter |month= ignored (help)
  2. ^ Nygren PA (2008). "Alternative binding proteins: affibody binding proteins developed from a small three-helix bundle scaffold". FEBS J. 275 (11): 2668–76. doi:10.1111/j.1742-4658.2008.06438.x. PMID 18435759. {{cite journal}}: Unknown parameter |month= ignored (help)
  3. ^ Ebersbach H, Fiedler E, Scheuermann T; et al. (2007). "Affilin-novel binding molecules based on human gamma-B-crystallin, an all beta-sheet protein". J. Mol. Biol. 372 (1): 172–85. doi:10.1016/j.jmb.2007.06.045. PMID 17628592. {{cite journal}}: Explicit use of et al. in: |author= (help); Unknown parameter |month= ignored (help)CS1 maint: multiple names: authors list (link)
  4. ^ Krehenbrink M, Chami M, Guilvout I, Alzari PM, Pécorari F, Pugsley AP (2008). "Artificial binding proteins (Affitins) as probes for conformational changes in secretin PulD". J. Mol. Biol. 383 (5): 1058–68. doi:10.1016/j.jmb.2008.09.016. PMID 18822295. {{cite journal}}: Unknown parameter |month= ignored (help)CS1 maint: multiple names: authors list (link)
  5. ^ Skerra A (2008). "Alternative binding proteins: anticalins - harnessing the structural plasticity of the lipocalin ligand pocket to engineer novel binding activities". FEBS J. 275 (11): 2677–83. doi:10.1111/j.1742-4658.2008.06439.x. PMID 18435758. {{cite journal}}: Unknown parameter |month= ignored (help)
  6. ^ Silverman J, Liu Q, Lu Q; et al. (2005). "Multivalent avimer proteins evolved by exon shuffling of a family of human receptor domains". Nat. Biotechnol. 23 (12): 1556–61. doi:10.1038/nbt1166. PMID 16299519. {{cite journal}}: Explicit use of et al. in: |author= (help); Unknown parameter |month= ignored (help)CS1 maint: multiple names: authors list (link)
  7. ^ Stumpp MT, Binz HK, Amstutz P (2008). "DARPins: a new generation of protein therapeutics". Drug Discov. Today. 13 (15–16): 695–701. doi:10.1016/j.drudis.2008.04.013. PMID 18621567. {{cite journal}}: Unknown parameter |month= ignored (help)CS1 maint: multiple names: authors list (link)
  8. ^ Stolc V (1991). "Polymorphism of cyclic 3',5'-adenosine monophosphate stimulation in rat erythrocytes". Acta Haematol. 85 (4): 195–8. PMID 1713012.
  9. ^ Nixon AE, Wood CR (2006). "Engineered protein inhibitors of proteases". Curr Opin Drug Discov Devel. 9 (2): 261–8. PMID 16566296. {{cite journal}}: Unknown parameter |month= ignored (help)
  10. ^ Koide A, Koide S (2007). "Monobodies: antibody mimics based on the scaffold of the fibronectin type III domain". Methods Mol. Biol. 352: 95–109. PMID 17041261.
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