Arginine alpha-ketoglutarate: Difference between revisions

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"At present, there is no research published in [[Peer review|peer-reviewed]] journals to support the assertion that an increase in nitric oxide levels promotes greater [[muscle]] [[protein synthesis]] or improves muscle strength. There is also no evidence that the arginine alpha-ketoglutarate in “nitric oxide” supplements have any effect on nitric oxide levels in muscles."<ref>[http://baye.com/no-supplements-no-way-2/ High Intensity Training by Drew Baye - NO Supplements? No Way!<!-- Bot generated title -->]</ref>{{Verify credibility|date=July 2009}}
"At present, there is no research published in [[Peer review|peer-reviewed]] journals to support the assertion that an increase in nitric oxide levels promotes greater [[muscle]] [[protein synthesis]] or improves muscle strength. There is also no evidence that the arginine alpha-ketoglutarate in “nitric oxide” supplements have any effect on nitric oxide levels in muscles."<ref>[http://baye.com/no-supplements-no-way-2/ High Intensity Training by Drew Baye - NO Supplements? No Way!<!-- Bot generated title -->]</ref>{{Verify credibility|date=July 2009}}

A recent study examined the effects of AAKG supplementation on heart rate, blood pressure, blood flow, NOx/NO2 levels, and l-arginine levels. Minimal observed changes were attributed to resistance exercise used in the experimental design, not to AAKG supplementation, although arginine levels were found to have been elevated.<ref>{{cite journal|last=Willoughby|first=DS|coauthors=Boucher T, Reid J, Skelton G, Clark M|title=Effects of 7 days of arginine-alpha-ketoglutarate supplementation on blood flow, plasma L-arginine, nitric oxide metabolites, and asymmetric dimethyl arginine after resistance exercise|journal=International Journal of Sport Nutrition and Exercise Metabolism|year=2011|month=Aug|volume=21|issue=4|pages=291-9|pmid=21813912}}</ref>


== References ==
== References ==
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[[Category:Bodybuilding supplements]]
[[Category:Bodybuilding supplements]]
Bill Campbell, M.S. et al. 2006. Pharmacokinetics, safety, and effects on exercise performance of l-arginine α-ketoglutarate in trained adult men. Nutrition, 22(9), 872-881.
Bill Campbell, M.S. et al. 2006. Pharmacokinetics, safety, and effects on exercise performance of l-arginine α-ketoglutarate in trained adult men. Nutrition, 22(9), 872-881.

Willoughby, DS et al. Aug 2011. Effects of 7 days of arginine-alpha-ketoglutarate supplementation on blood flow, plasma L-arginine, nitric oxide metabolites, and asymmetric dimethyl arginine after resistance exercise. International Journal of Sport Nutrition and Exercise Metabolism, 21(4):291-9.

Revision as of 16:29, 29 November 2011

Arginine alpha-ketoglutarate (AAKG) is a salt of the amino acid arginine and alpha-ketoglutaric acid. It is marketed as a body building supplement. The components are intermediates in the metabolism of nitric oxides, but no reputable scientific evidence shows any benefits from taking AAKG as a dietary supplement.

"At present, there is no research published in peer-reviewed journals to support the assertion that an increase in nitric oxide levels promotes greater muscle protein synthesis or improves muscle strength. There is also no evidence that the arginine alpha-ketoglutarate in “nitric oxide” supplements have any effect on nitric oxide levels in muscles."[1][unreliable source?]

A recent study examined the effects of AAKG supplementation on heart rate, blood pressure, blood flow, NOx/NO2 levels, and l-arginine levels. Minimal observed changes were attributed to resistance exercise used in the experimental design, not to AAKG supplementation, although arginine levels were found to have been elevated.[2]

References

  1. ^ High Intensity Training by Drew Baye - NO Supplements? No Way!
  2. ^ Willoughby, DS (2011). "Effects of 7 days of arginine-alpha-ketoglutarate supplementation on blood flow, plasma L-arginine, nitric oxide metabolites, and asymmetric dimethyl arginine after resistance exercise". International Journal of Sport Nutrition and Exercise Metabolism. 21 (4): 291–9. PMID 21813912. {{cite journal}}: Unknown parameter |coauthors= ignored (|author= suggested) (help); Unknown parameter |month= ignored (help)

Bill Campbell, M.S. et al. 2006. Pharmacokinetics, safety, and effects on exercise performance of l-arginine α-ketoglutarate in trained adult men. Nutrition, 22(9), 872-881.