Abexinostat: Difference between revisions

Abexinostat
Names
	IUPAC name 3-[(Dimethylamino)methyl]-N-{2-[4-(hydroxycarbamoyl)phenoxy]ethyl}-1-benzofuran-2-carboxamide
	Other names PCI-24781; CRA-024781
Identifiers
CAS Number	783355-60-2 ; 783356-67-2 (HCl) ;
3D model (JSmol)	Interactive image;
ChemSpider	9924562;
ECHA InfoCard	100.241.399
PubChem CID	11749858;
CompTox Dashboard (EPA)	DTXSID30229005 ;
	InChI InChI=1S/C21H23N3O5/c1-24(2)13-17-16-5-3-4-6-18(16)29-19(17)21(26)22-11-12-28-15-9-7-14(8-10-15)20(25)23-27/h3-10,27H,11-13H2,1-2H3,(H,22,26)(H,23,25) Key: MAUCONCHVWBMHK-UHFFFAOYSA-N; InChI=1/C21H23N3O5/c1-24(2)13-17-16-5-3-4-6-18(16)29-19(17)21(26)22-11-12-28-15-9-7-14(8-10-15)20(25)23-27/h3-10,27H,11-13H2,1-2H3,(H,22,26)(H,23,25) Key: MAUCONCHVWBMHK-UHFFFAOYAM;
	SMILES O=C(NO)c3ccc(OCCNC(=O)c2oc1ccccc1c2CN(C)C)cc3;
Properties
Chemical formula	C21H23N3O5
Molar mass	397.431 g·mol−1
	Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa). Infobox references

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Revision as of 19:01, 5 March 2012

Abexinostat (INN,^[1] formerly PCI-24781) is an experimental drug candidate for cancer treatment.^[2] It is currently under development by Pharmacyclics and is in Phase II clinical trials for B-cell lymphoma.^[3] Pre-clinical study suggests the potential for treatment of different types of cancer as well.^[4]^[5]^[6]^[7]

Abexinostat exerts its effect as a histone deacetylase inhibitor.^[8]^[9]

References

^ WHO Drug Information, Vol. 25, No. 2, 2011
^ Abexinostat, NCI Cancer Dictionary
^ Abexinostat HCl (PCI-24781), PanHDAC-inhibitor, Pharmacyclics
^ . PMID 19417023. {{cite journal}}: Cite journal requires |journal= (help); Missing or empty |title= (help)
^ . PMID 19417021. {{cite journal}}: Cite journal requires |journal= (help); Missing or empty |title= (help)
^ . PMID 20145726. {{cite journal}}: Cite journal requires |journal= (help); Missing or empty |title= (help)
^ . PMID 20461381. {{cite journal}}: Cite journal requires |journal= (help); Missing or empty |title= (help)
^ . PMID 16731764. {{cite journal}}: Cite journal requires |journal= (help); Missing or empty |title= (help)
^ . PMID 18042714. {{cite journal}}: Cite journal requires |journal= (help); Missing or empty |title= (help)

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[1] WHO Drug Information, Vol. 25, No. 2, 2011

[2] Abexinostat, NCI Cancer Dictionary

[3] Abexinostat HCl (PCI-24781), PanHDAC-inhibitor, Pharmacyclics

[4] . PMID 19417023. {{cite journal}}: Cite journal requires |journal= (help); Missing or empty |title= (help)

[5] . PMID 19417021. {{cite journal}}: Cite journal requires |journal= (help); Missing or empty |title= (help)

[6] . PMID 20145726. {{cite journal}}: Cite journal requires |journal= (help); Missing or empty |title= (help)

[7] . PMID 20461381. {{cite journal}}: Cite journal requires |journal= (help); Missing or empty |title= (help)

[8] . PMID 16731764. {{cite journal}}: Cite journal requires |journal= (help); Missing or empty |title= (help)

[9] . PMID 18042714. {{cite journal}}: Cite journal requires |journal= (help); Missing or empty |title= (help)

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