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'''SAM domain and HD domain-containing protein 1''' is a [[protein]] that in humans is encoded by the ''SAMHD1'' [[gene]]. SAMHD1 is responsible for blocking replication of [[HIV]] in [[dendritic cells]] |
'''SAM domain and HD domain-containing protein 1''' is a [[protein]] that in humans is encoded by the ''SAMHD1'' [[gene]]. SAMHD1 is responsible for blocking replication of [[HIV]] in [[dendritic cells]]<ref>{{cite journal|last=Laguette|first=N.|coauthors=et al.|title=SAMHD1 is the dendritic- and myeloid-cell-specific HIV-1 restriction factor counteracted by Vpx|journal=Nature|year=2011|pmid=21613998}}</ref>, [[macrophages]]<ref>{{cite journal|last=Hrecka|first=K.|coauthors=et al.|title=Vpx relieves inhibition of HIV-1 infection of macrophages mediated by the SAMHD1 protein|journal=Nature|year=2011|pmid=21720370}}</ref>and [[monocytes]]<ref>{{cite journal|last=Berger|first=A.|coauthors=et al.|title=SAMHD1-deficient CD14+ cells from individuals with Aicardi-Goutières syndrome are highly susceptible to HIV-1 infection|journal=PLoS Phatog.|year=2011|pmid=22174685}}</ref>. It is an [[enzyme]] that exhibits phosphohydrolase activity<ref> {{cite pmid|22056990}}</ref>, converting [[nucleotide triphosphates|nucleotide triphosphate]]s to a [[nucleoside]] and triphosphate. In doing so, SAMHD1 depletes the pool of nucleotides available to a [[reverse transcriptase]] for viral c[[DNA]] synthesis and thus prevents viral replication<ref name="pmid22327569">{{cite journal | author = Lahoussa, H. ''et al.'' | title = SAMHD1 restricts the replication of human immunodeficiency virus type 1 by depleting the intracellular pool of deoxynucleoside triphosphates | journal = Nature Immunology | volume = 13 | issue = | pages = 223-228 | year = 2012 | month = | pmid = 22327569 | doi = 10.1038/ni.2236 }}</ref>. |
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==References== |
==References== |
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Revision as of 15:55, 6 September 2012
Template:PBB SAM domain and HD domain-containing protein 1 is a protein that in humans is encoded by the SAMHD1 gene. SAMHD1 is responsible for blocking replication of HIV in dendritic cells[1], macrophages[2]and monocytes[3]. It is an enzyme that exhibits phosphohydrolase activity[4], converting nucleotide triphosphates to a nucleoside and triphosphate. In doing so, SAMHD1 depletes the pool of nucleotides available to a reverse transcriptase for viral cDNA synthesis and thus prevents viral replication[5].
References
- ^ Laguette, N. (2011). "SAMHD1 is the dendritic- and myeloid-cell-specific HIV-1 restriction factor counteracted by Vpx". Nature. PMID 21613998.
{{cite journal}}: Unknown parameter|coauthors=ignored (|author=suggested) (help) - ^ Hrecka, K. (2011). "Vpx relieves inhibition of HIV-1 infection of macrophages mediated by the SAMHD1 protein". Nature. PMID 21720370.
{{cite journal}}: Unknown parameter|coauthors=ignored (|author=suggested) (help) - ^ Berger, A. (2011). "SAMHD1-deficient CD14+ cells from individuals with Aicardi-Goutières syndrome are highly susceptible to HIV-1 infection". PLoS Phatog. PMID 22174685.
{{cite journal}}: Unknown parameter|coauthors=ignored (|author=suggested) (help) - ^ Attention: This template ({{cite pmid}}) is deprecated. To cite the publication identified by PMID 22056990, please use {{cite journal}} with
|pmid=22056990instead. - ^ Lahoussa, H.; et al. (2012). "SAMHD1 restricts the replication of human immunodeficiency virus type 1 by depleting the intracellular pool of deoxynucleoside triphosphates". Nature Immunology. 13: 223–228. doi:10.1038/ni.2236. PMID 22327569.
{{cite journal}}: Cite has empty unknown parameter:|month=(help); Explicit use of et al. in:|author=(help)
Further reading
- Attention: This template ({{cite pmid}}) is deprecated. To cite the publication identified by PMID 22177690, please use {{cite journal}} with
|pmid=22177690instead. - Olsen JV, Blagoev B, Gnad F; et al. (2006). "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks". Cell. 127 (3): 635–48. doi:10.1016/j.cell.2006.09.026. PMID 17081983.
{{cite journal}}: Explicit use of et al. in:|author=(help)CS1 maint: multiple names: authors list (link) - Ota T, Suzuki Y, Nishikawa T; et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
{{cite journal}}: Explicit use of et al. in:|author=(help)CS1 maint: multiple names: authors list (link) - Strausberg RL, Feingold EA, Grouse LH; et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
{{cite journal}}: Explicit use of et al. in:|author=(help)CS1 maint: multiple names: authors list (link) - Wistow G, Bernstein SL, Wyatt MK; et al. (2002). "Expressed sequence tag analysis of human RPE/choroid for the NEIBank Project: over 6000 non-redundant transcripts, novel genes and splice variants". Mol. Vis. 8: 205–20. PMID 12107410.
{{cite journal}}: Explicit use of et al. in:|author=(help)CS1 maint: multiple names: authors list (link) - Deloukas P, Matthews LH, Ashurst J; et al. (2002). "The DNA sequence and comparative analysis of human chromosome 20". Nature. 414 (6866): 865–71. doi:10.1038/414865a. PMID 11780052.
{{cite journal}}: Explicit use of et al. in:|author=(help)CS1 maint: multiple names: authors list (link) - Simpson JC, Wellenreuther R, Poustka A; et al. (2001). "Systematic subcellular localization of novel proteins identified by large-scale cDNA sequencing". EMBO Rep. 1 (3): 287–92. doi:10.1093/embo-reports/kvd058. PMC 1083732. PMID 11256614.
{{cite journal}}: Explicit use of et al. in:|author=(help)CS1 maint: multiple names: authors list (link)
External links
- GeneReviews/NCBI/NIH/UW entry on Aicardi-Goutières Syndrome
- OMIM entries on Aicardi-Goutieres syndrome
 | This article on a gene on human chromosome 20 is a stub. You can help Wikipedia by expanding it. |