ORFeome: Difference between revisions
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Orfeome is the complete collection of [[open reading frames]] (ORF) that exists in the genome. More specifically, ORFeome refers to a set of cloned ORFs. |
Orfeome is the complete collection of [[open reading frames]] (ORF) that exists in the genome. More specifically, ORFeome refers to a set of cloned ORFs.<ref name="ORFcloning">{{Cite pmid| 19718504}}</ref> |
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ORFs correspond to the coding sequences (CDS) of [[gene]]s. ORFs can be found in genome sequences by computer programs such as [[GENSCAN]]. While this is relatively trivial in [[bacteria]] the problem is non-trivial in [[eukaryote | eukaryotic]] [[genome]]s because of the presence of [[intron]]s and [[exon]]s. |
ORFs correspond to the coding sequences (CDS) of [[gene]]s. ORFs can be found in genome sequences by computer programs such as [[GENSCAN]]. While this is relatively trivial in [[bacteria]] the problem is non-trivial in [[eukaryote | eukaryotic]] [[genome]]s because of the presence of [[intron]]s and [[exon]]s. |
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The usage of complete ORFeomes reflects a new trend in biology that can be succinctly summarized as [[omics]]. |
The usage of complete ORFeomes reflects a new trend in biology that can be succinctly summarized as [[omics]]. For instance, ORFeomes are used for the study of protein-protein interactions.<ref name="TP">{{Cite pmid| 18509523}}</ref><ref name="virusORfeome">{{Cite pmid| 15489322}}</ref> |
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==Cloned ORFeomes== |
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Complete ORF sets have been cloned for a number of organisms including |
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* Escherichia coli<ref name="EcoliORFeome">{{Cite pmid| 20701780}}</ref> |
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* Brucella melitensis<ref name="BmeORFeome">{{Cite pmid| 19524659}}</ref> |
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* Staphylococcus aureus<ref name="SauORFeome">{{Cite pmid| 18605992}}</ref> |
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* human herpesviruses<ref name="herpesORFeome">{{Cite pmid| 19730696}}</ref> |
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==References== |
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{{Reflist}} |
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{{DEFAULTSORT:Orfeome}} |
{{DEFAULTSORT:Orfeome}} |
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Revision as of 21:24, 7 December 2012
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Orfeome is the complete collection of open reading frames (ORF) that exists in the genome. More specifically, ORFeome refers to a set of cloned ORFs.[1] ORFs correspond to the coding sequences (CDS) of genes. ORFs can be found in genome sequences by computer programs such as GENSCAN. While this is relatively trivial in bacteria the problem is non-trivial in eukaryotic genomes because of the presence of introns and exons. The usage of complete ORFeomes reflects a new trend in biology that can be succinctly summarized as omics. For instance, ORFeomes are used for the study of protein-protein interactions.[2][3]
Cloned ORFeomes
Complete ORF sets have been cloned for a number of organisms including
References
- ^ Attention: This template ({{cite pmid}}) is deprecated. To cite the publication identified by PMID 19718504, please use {{cite journal}} with
|pmid= 19718504instead. - ^ Attention: This template ({{cite pmid}}) is deprecated. To cite the publication identified by PMID 18509523, please use {{cite journal}} with
|pmid= 18509523instead. - ^ Attention: This template ({{cite pmid}}) is deprecated. To cite the publication identified by PMID 15489322, please use {{cite journal}} with
|pmid= 15489322instead. - ^ Attention: This template ({{cite pmid}}) is deprecated. To cite the publication identified by PMID 20701780, please use {{cite journal}} with
|pmid= 20701780instead. - ^ Attention: This template ({{cite pmid}}) is deprecated. To cite the publication identified by PMID 19524659, please use {{cite journal}} with
|pmid= 19524659instead. - ^ Attention: This template ({{cite pmid}}) is deprecated. To cite the publication identified by PMID 18605992, please use {{cite journal}} with
|pmid= 18605992instead. - ^ Attention: This template ({{cite pmid}}) is deprecated. To cite the publication identified by PMID 19730696, please use {{cite journal}} with
|pmid= 19730696instead.