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Androgen deprivation-induced senescence (or ADIS) refers to the induction of cellular senescence by the withdrawal of androgen[1] [2] [3] . ADIS is associated with prostate cancer cells that are dependent on androgens for cell proliferation. Androgen withdrawal induces cells to undergo cellular senescence by up-regulating intracellular reactive oxygen species (ROS) that cause DNA damage. ADIS is maintained through the up-regulation of the cell cycle regulator p16ink4a.
References
- ^ Pernicová, Z (2011 Jun). "Androgen depletion induces senescence in prostate cancer cells through down-regulation of Skp2". Neoplasia (New York, N.Y.). 13 (6): 526–36. PMID 21677876.
{{cite journal}}: Check date values in:|date=(help); Unknown parameter|coauthors=ignored (|author=suggested) (help) - ^ Ewald, JA (2013 Mar). "Androgen deprivation induces senescence characteristics in prostate cancer cells in vitro and in vivo". The Prostate. 73 (4): 337–45. PMID 22911222.
{{cite journal}}: Check date values in:|date=(help); Unknown parameter|coauthors=ignored (|author=suggested) (help) - ^ Burton, Dominick G. A. (27 June 2013). "Androgen Deprivation-Induced Senescence Promotes Outgrowth of Androgen-Refractory Prostate Cancer Cells". PLoS ONE. 8 (6): e68003. doi:10.1371/journal.pone.0068003.
{{cite journal}}: Unknown parameter|coauthors=ignored (|author=suggested) (help)CS1 maint: unflagged free DOI (link)